Open Actively Recruiting

Cognition and Imaging With Tigertriever

About

Brief Summary

The objective of the COGNITIVE Study is to evaluate whether successful reperfusion with Tigertriever is associated with cognitive benefit.

Study Type
Observational

Eligibility

Gender
All
Healthy Volunteers
No
Minimum Age
18 Years
Maximum Age
75 Years

Inclusion Criteria:

  • Patients admitted with large vessel occlusion (LVO) and treated with the Tigertriever, as indicated per the approved IFU.
  • Tigertriever was used as the first line treatment in the target vessel.
  • A signed informed consent.
  • Age 18-75 years (inclusive).
  • No known significant pre-stroke disability (pre-stroke mRS 0 or 1).

Exclusion Criteria:

  • Use of any other IA recanalization device prior to the Tigertriever in the target vessel, including aspiration catheter.
  • Evidence of acute brain hemorrhage on CT and/or MRI at admission.
  • Prior hemorrhage, stroke, thrombolysis, and/or endovascular therapy in the last 3 months.
  • Probable cerebral amyloid angiopathy.
  • Pre-stroke diagnosed dementia and/or prescribed cholinesterase inhibitors.
  • Pre-stroke diagnosed and/or currently treated major depression.
  • Pre-stroke learning or intellectual disability.
  • Anticipated inability to obtain 6-month follow-up assessments.

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Study Stats
Protocol No.
24-5055
Category
Heart/Cardiovascular Diseases
Location
  • UCLA Westwood
For Providers
NCT No.
NCT05531461
For detailed technical eligibility, visit ClinicalTrials.gov.