Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients

About

Brief Summary

A multicenter, randomized, adaptive allocation clinical trial to determine if increasing durations of induced hypothermia are associated with an increasing rate of good neurological outcomes and to identify the optimal duration of induced hypothermia for neuroprotection in comatose survivors of cardiac arrest.

Primary Purpose

Treatment

Study Type

Interventional

Phase

N/A

Eligibility

Gender

All

Healthy Volunteers

No

Minimum Age

18 Years

Maximum Age

N/A

Inclusion Criteria:

Coma after resuscitation from out of hospital cardiac arrest
Cooled to <34 deg C with 240 minutes of cardiac arrest
Definitive temperature control applied
Age ≥ 18 years
Informed consent from legal authorized representative (LAR) including intent to maintain life support for 96 hours
Enrollment within 6 hours of initiation of cooling

Exclusion Criteria:

Hemodynamic instability
Pre-existing neurological disability or condition that confounds outcome determination
Pre-existing terminal illness, unlikely to survive to outcome determination
Planned early withdrawal of life support
Presumed sepsis as etiology of arrest
Prisoner

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