Motivation for IV Alcohol Self-Administration in Humans

To be included in the study, participants must:

• Be between the ages of 21 and 65
• Have self-reported alcohol use in the past 30 days
• Meet current (i.e., past 12 months) DSM-5 diagnostic criteria for alcohol use disorder mild-to-severe

To be included in the study, participants must not:

• Currently be treatment seeking, in treatment for alcohol use, or have a history of treatment in the 30 days prior to consent
• Have current (last 12 months) DSM-5 diagnosis of substance use disorder for any psychoactive substances other than alcohol and nicotine
• Have a lifetime DSM-5 diagnosis of schizophrenia, bipolar disorder, or any other psychotic disorder
• Have current suicidal ideation or lifetime history of suicide attempt as reported on the Columbia-Suicide Severity Rating Scale (C-SSRS)
• Have a positive urine screen for drugs other than cannabis
• Be pregnant, nursing, or planning to become pregnant while taking part in the study; and must agree to one of the following methods of birth control (if female), unless she or partner are surgically sterile:
  • Oral contraceptives
  • Contraceptive sponge
  • Patch
  • Double barrier
  • Intrauterine contraceptive device
  • Etonogestrel implant
  • Medroxyprogesterone acetate contraceptive injection
  • Hormonal vaginal contraceptive ring
  • Complete abstinence from sexual intercourse
• Have clinically significant abnormalities identified in the physical exam that may interfere with safe study participation (e.g. unstable cardiac, renal, or liver disease; diabetes; uncontrolled hypertension; or HIV)
• Exceed Grade 2 laboratory abnormalities, based on FDA Guidance Document "Toxicity Grading Scale for Healthy Adult and Adolescent Volunteers Enrolled in Preventive Vaccine Clinical Trials"
• Currently use any medications known to interact with alcohol, including: antidepressants, anticonvulsants, opioids, benzodiazepines, medications for diabetes, and medications that affect alcohol metabolism
• Have an intense fear of needles or have had adverse reactions to needle puncture
• Have any other circumstances that, in the opinion of the investigators, would not be a good fit for study participation

To participate in the IV alcohol administration, participants must not:

• Have a BrAC > 0.000 g/dl
• Have clinically significant alcohol withdrawal symptoms as indicated by a score ≥ 10 on the Clinical Institute Withdrawal Assessment for Alcohol-Revised (CIWA-R)
• Exceed Grade 2 clinical vital sign abnormalities, based on FDA Guidance Document "Toxicity Grading Scale for Healthy Adult and Adolescent Volunteers Enrolled in Preventive Vaccine Clinical Trials"