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Nafamostat Efficacy in Phase 3 Registrational CRRT Study

About

Brief Summary

A prospective, randomized, placebo-controlled clinical study to investigate the safety and efficacy of Niyad (nafamostat mesylate) for anticoagulation of extracorporeal blood circulating through a dialysis filter in patients undergoing CRRT who cannot tolerate heparin or are at higher risk for bleeding.

Primary Purpose
Treatment
Study Type
Interventional
Phase
Phase 3

Eligibility

Gender
All
Healthy Volunteers
No
Minimum Age
18 Years
Maximum Age
80 Years

Inclusion Criteria:

  • Patients requiring CRRT or undergoing CRRT initiated within the prior 48 hours
  • Patients who cannot tolerate heparin or are at high risk of bleeding

Exclusion Criteria:

  • Patients weighing less than 50 kg
  • Patients receiving systemic anticoagulation
  • Patients with active bleeding

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Study Stats
Protocol No.
23-5258
Category
Genitourinary Disorders
Contact
Jennifer Scovotti
Location
  • UCLA Westwood
For Providers
NCT No.
NCT06150742
For detailed technical eligibility, visit ClinicalTrials.gov.