PANDORA: Delirium Prevention After Cardiac Surgery Using IV Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients

About

Brief Summary

Our objective is to find an effective prophylactic intervention by evaluating IV acetaminophen's impact in reducing the frequency of postoperative delirium, one of the most common and detrimental complications of cardiac surgery in older adults.

Primary Purpose

Prevention

Study Type

Interventional

Phase

Phase 3

Eligibility

Gender

All

Healthy Volunteers

No

Minimum Age

60 Years

Maximum Age

N/A

Inclusion Criteria:

≥ 60 years of age
Patients undergoing cardiac surgery [coronary artery bypass grafting (CABG) with or without valve, isolated valve surgery] requiring cardiopulmonary bypass

Exclusion Criteria:

Pre-operative left ventricular ejection fraction (LVEF) < than 30%
Emergent procedures
Isolated aortic surgery
Liver dysfunction (liver enzymes > 3 times the baseline, all patients will have a baseline liver function test information), history and exam suggestive of jaundice
Hypersensitivity to the study drugs
Active (in the past year) history of alcohol abuse (≥5 drinks per day for men or ≥ 4 drinks per day for women)
Any history of alcohol withdrawal or delirium tremens
Delirium at baseline
Non-English speaking
Prisoners
Physician Refusal
COVID-19 Positive, symptomatic
Co-enrollment with non-approved interventional trial