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Retro-active Immunological Tolerance in Patients With Well-functioning Pre-existing HLA-identical Kidney Transplants

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Brief Summary

The study seeks to determine if patients with a pre-existing, well-functioning kidney transplant from a HLA-identical living donor can be withdrawn from immunosuppressive medications without compromising allograft function through hematopoietic stem cell (HPSC) infusion from the same donor. HPSC infusion will be preceded by a conditioning regimen of total lymphoid irradiation (TLI) and rabbit anti-thymocyte globulin (rATG).

Primary Purpose
Treatment
Study Type
Interventional
Phase
Phase 1

Eligibility

Gender
All
Healthy Volunteers
Yes
Minimum Age
18 Years
Maximum Age
N/A

Recipient Inclusion Criteria

Recipient Exclusion Criteria

Donor Inclusion Criteria

Donor Exclusion Criteria

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Study Stats
Protocol No.
22-001470
Category
Immune System/Transplant Related Disorders
Contact
DANA LEVIN-LOPEZ
Location
  • UCLA Santa Monica
  • UCLA Westwood
For Providers
NCT No.
NCT05525507
For detailed technical eligibility, visit ClinicalTrials.gov.