Study of Magnetic Resonance Image and Computed Tomography-Guided Stereotactic Body Radiation Therapy for Abdominopelvic Sarcomas (MARS Trial)
About
Recent advances in radiation treatment have allowed for higher doses per treatment to be delivered safely. This study plans to use an MRI-guided linear accelerator to deliver the radiation treatment to ensure that the radiation dose is administered to the cancerous tumor, not the vital body organs.
Potential participants with a sarcoma diagnosis will be referred to Radiation Oncology during this study. If the participant is interested in participating in this study, s/he receives radiation treatment daily for 5 consecutive days except for weekends and holidays. Within 12 weeks of completing the radiation therapy, the participant will have the primary tumor surgically removed. The radiation oncology team will follow the patients for 5 years after completing radiation therapy.
Eligibility
Inclusion Criteria:
- Histologically confirmed sarcoma
- Primary or recurrent disease involving the abdomen or pelvis
- Resectable primary lesion
- Age ≥ 12 years old
- Karnofsky performance status (KPS) ≥ 70 or Eastern Cooperative Oncology Group (ECOG) 0-2
- If a woman is of childbearing potential, a negative serum or urine pregnancy test must be documented
Exclusion Criteria:
- Active treatment of a separate malignancy
- History of prior irradiation to the area targeted for treatment
Join this Trial
- UCLA Westwood