Type 2 Diabetes and Blood Brain Barrier Improvement

About

Brief Summary

The majority of T2DM adults show thiamine (vitamin B1) deficiency which may contribute to impaired function. This study will examine patients with T2DM through brain MRI scans, cognition assessments, blood tests, and questionnaires. Our goal is to see if a thiamine treatment (taking vitamin B1 capsules) can improve function. Patients will be asked to come to UCLA two times three months apart and each visit will last about 2.5-3 hours.

Primary Purpose

Prevention

Study Type

Interventional

Phase

Early Phase 1

Eligibility

Gender

All

Healthy Volunteers

No

Minimum Age

40 Years

Maximum Age

65 Years

Inclusion Criteria:

Diagnosed T2DM
Outpatient status
Able to lay flat for imaging

Exclusion Criteria:

A previous history of stroke
Current in-take of thiamine
Known thiamine allergy
Seizure disorder
Head trauma
Myocardial infarction
Current pregnancy (if female)
Diagnosed neuropsychiatric disorders (clinical depression, schizophrenia, manic-depression)
Diagnosed dementia
Sleep disordered breathing
Airway or chest deformities that would interfere with breathing
Chronic obstructive pulmonary disease
Cystic fibrosis
Presence of brain mass lesions
Any history of drug abuse (e.g., cocaine, tobacco, or cannabis)
Renal failure (requiring dialysis)
All T2DM adults with metallic and electronic implants (phrenic or cardiac pacemakers; although some pacemakers and cardioverter defibrillators are safe at a low magnetic field, they are not safe at 3.0-Tesla scanner)
Non-removable insulin pump/glucose sensor
Braces
Body weight more than 300 pounds (weight and height will be used to calculate BMI to determine if the patient will fit in the scanner and stay within parameters of size restrictions of MRI scanner table)
Any other contraindications to MRI, such as claustrophobia, or metallic-based tattoos, as per MRI safety website suggestions, will also be excluded.