Church Lab
Researching the bidirectional interactions between the brain and the gut in shaping health and disease
![Illustration of brain and gut](/sites/default/files/styles/landscape_3x2_016000_640x427_mobile_hero/public/banner-images/Gupta-Lab-Banner.jpg?f=f1b39274&itok=6YnmgRN-)
![Arpana Gupta, PhD](/sites/default/files/styles/landscape_3x2_032000_1280x853/public/images/05/guptaarpana-x5p3594.jpg?f=73c8dd0e&itok=9l8DFTC-)
About Us
Dr. Church’s research aims to bring a systems biology-based, comprehensive understanding of the pathophysiology underlying human obesity and the cluster of obesity-related conditions known as metabolic syndrome.
Now streaming on Netflix
Dr. Church participates in this informative Netflix documentary that demystifies the role gut health plays in our overall well-being.
![Hack Your Health - Netflix](/sites/default/files/styles/landscape_3x2_032000_1280x853/public/images/83/hackyourhealth-netflix.jpg?f=8f540c06&itok=_kZ74qwR)
![Little boy crying](/sites/default/files/styles/landscape_3x2_032000_1280x853/public/images/Gupta-Lab-Environmental-Influences.jpg?h=aecb86f4&f=648d2603&itok=RUKiyBm1)
Environmental Influences
Psychosocial, cultural and environmental challenges, such as adverse childhood experiences, acculturation, neighborhood safety, family environment, and socioeconomic status heighten stress-related biological and behavioral pathways that increase the vulnerability to disease-promoting behaviors.
Latest News
![Image](/sites/default/files/styles/landscape_16x9_016000_640x360/public/images/f2/lonely-woman-ucla-health-2.jpg?f=be2cdf5e&itok=C7eLfjnj)
Feeding the lonely brain
A new UCLA Health study has found that women who perceive themselves to be lonely exhibited activity in regions of the brain associated with cravings and motivation towards eating, especially when shown pictures of high-calorie foods such as sugary foods. The same group of women also had unhealthy eating behaviors and poor mental health.
![Little boy crying](/sites/default/files/styles/landscape_16x9_016000_640x360/public/images/Gupta-Lab-Environmental-Influences.jpg?h=aecb86f4&f=648d2603&itok=7kBT50Ck)
The association between disadvantaged neighborhoods and cortical microstructure and their relation to obesity
According to newly published research in Nature, living in a disadvantaged neighborhood can affect food choices, weight gain and even the microstructure of the brain.
![mood stress](/sites/default/files/styles/landscape_16x9_016000_640x360/public/images/icon-mood-stress-wellness.gif?h=038a9462&itok=fyu9SZQn)
Your gut microbes may influence how you handle stress
A new UCLA Health study, led by Arpana Church, PhD, has found that resilient people exhibit neural activity in the brain regions associated with improved cognition and regulating of emotions, and were more mindful and better at describing their feelings. The same group also exhibited gut microbiome activity linked to a healthy gut, with reduced inflammation and gut barrier.