Manish Butte, MD, PhD
(he/him) - Allergy and Immunology
About
Manish J. Butte, MD, PhD is the E. Richard Stiehm Endowed Chair and Professor with tenure in the Department of Pediatrics at UCLA, and Division Chief of Immunology, Allergy, and Rheumatology. He has a joint appointment in the Department of Microbiology, Immunology, and Molecular Genetics. He studied Physics and also earned his MD at Brown University. He then studied structural biology at UCSF and graduated with a PhD in Biophysics. Returning to clinical training, he completed a Pediatrics residency at the Children's Hospital of Philadelphia and a clinical fellowship in Allergy & Immunology at Boston Children's Hospital. He did post-doctoral research at Harvard and worked on T-cell inhibitory pathways and chemistry. He spent his junior faculty years at Stanford University (2009-2016) and moved to UCLA in late 2016.
Academic Office Location
UCLA Pediatrics / Immunology
10833 Le Conte Avenue
MDCC Building, Room 12-430
Los Angeles, CA 90095
Research Lab Location
CHS Building, 4th floor, room 46-100
Research Lab Shipments
Butte Lab @ UCLA
650 Charles E Young Dr. South
CHS Building, Room 46-100
Los Angeles CA, 90095
Clinical Interests
- Immune Deficiencies in pediatric and adult patients
- Recurrent/frequent infections in pediatric and adult patients
- Genetic diagnosis of immune deficiencies for pediatric and adult patients
- Immune globulin replacement for pediatric and adult patients with immunodeficiency
- Monogenic, rare autoimmune diseases
- Disseminated Valley fever (coccidioidomycosis)
Languages
Education
Medical Board Certifications
Fellowships
Residency
Degrees
Recognitions
- Top Doctors, Los Angeles Magazine, 2023
- American Society for Clinical Investigation, 2021
- Fellow of the Clinical Immunology Society, 2021
Related Clinical Trials
Locations
Hospital Affiliations
Ronald Reagan UCLA Medical Center
UCLA Santa Monica Medical Center
UCLA Mattel Children's Hospital
Medical Services
Areas of Focus
Research
Interests
A major research focus of his lab is to study T cells, the coordinating cells of the immune response, with a specific focus on infections, autoimmunity, and cancer. This work has been funded by the NIH and NSF. The second major focus of his lab is in improving the diagnosis and treatment of patients with rare, genetic immune diseases (primary immunodeficiency or inborn errors of immunity). He cares for children and adults with rare diseases in his clinic, which is supported by Jeffrey Modell Foundation. He is a co-Investigator in the NIH-funded Undiagnosed Diseases Network. He is one of the founding co-directors of the California Center for Rare Diseases. Dr. Butte's lab has trained 8 PhD students (5 completed and 2 currently), 6 postdocs (5 completed, 1 currently), and mentored many undergraduate and graduate students. His lab has publised over 100 papers with over 19,000 citations.
Publications
In the News
- UCLA-led team gets $8.4 million NIH grant to probe mysteries of Valley fever, UCLA Newsroom
- Tiny implantable device designed by UCLA scientists helps kill cancer, UCLA Newsroom
- UCLA researchers study genetics’ role in COVID-19 susceptibility, severity, UCLA Newsroom
- Reprogramming of immune system cures child with often-fatal fungal infection, UCLA Newsroom
Insurance
- Aetna
- Anthem Blue Cross
- Blue Shield of California
- Centivo
- Cigna
- First Health
- Health Net of California
- Interplan (part of HealthSmart)
- L.A. Care
- Medicare Advantage
- MultiPlan
- UFCM Health System
- Prime Health Services
- Private Healthcare Systems (PHCS)
- TRICARE
- UnitedHealthcare
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Recognitions
- Top Doctors, Los Angeles Magazine, 2023
- American Society for Clinical Investigation, 2021
- Fellow of the Clinical Immunology Society, 2021