Pediatric Neurosurgery

High Frequency Oscillation

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High Frequency Oscillation in Pediatric Epilepsy Surgery

UCLA Pediatric Epilepsy Surgery Clinical Trial

Title: High Frequency Oscillation in Pediatric Epilepsy Surgery

Study Team: Joyce Wu, MD; Aria Fallah, MD, MS; Shaun Hussain, MD, MS; Raman Sankar, MD, PhD; Hiroki Nariai, MD, Kristina Murata, RN, MSN, FNP-BC.

Mattel Children’s Hospital at UCLA
Division of Pediatric Neurology
Room 22-474 MDCC
10833 Le Conte Avenue
Los Angeles, CA 90095-1752

What is the purpose of the research? Recently, it has been discovered that we can measure other epileptic activity called high frequency oscillations (HFOs), by recording EEGs at a higher frequency rate. These HFOs on the EEG recordings appear to point out the epileptic brain tissue better than epileptic spikes or seizure onset zones.

During the epilepsy surgery, EEG (brain signals) is measured on the brain to confirm where in your child's brain the epilepsy is coming from. We measure these brain signals with electrodes placed directly on the brain during surgery. We want to look at these EEG signals in an additional new way because we think that we can better localize the area with epilepsy.

In this study we will compare the two groups of patients to see what works best for a seizure-free outcome: surgery based on standard clinical practice only, or surgery based on standard clinical practice and tailored with HFO location. Your child will be randomly assigned to either group. The results of this study may change the way we operate on epilepsy surgery patients in the future.

Regardless of what treatment arm your child is assigned to, there will be no deviation to the current clinical standard of care practice.

To be eligible, study participants must:

Be between 1-21 years old.
Have been diagnosed with refractory epilepsy.
Are being considered for epilepsy surgery to better control seizures/epilepsy (Non-UCLA patients would need to be referred to the UCLA Epilepsy Surgical Program to be considered for the study).