November 2024: The research “Therapeutic potential of targeting IRES-dependent c-myc translation in multiple myeloma cells during ER stress” published in the journal Oncogene in 2016 and highlighted in the 2016 press release below has been retracted. The article was retracted because of significant concerns regarding a number of figures presented in the work, which brought into question the integrity of the data.
Please do not cite this research in future reporting.
UCLA scientists have developed a new drug therapy to treat multiple myeloma, the second most common blood cancer in the United States. This first-of-its-kind experimental treatment would prevent myeloma cells—which accumulate in the bone marrow where they eventually push out healthy blood cells—from growing to slow or stop the spread of the disease.
In the one-year study, UCLA researchers analyzed the effects of an experimental drug called compound 11 in myeloma cell lines. They combined it with another drug, bortezomib (Velcade), which was approved by the U.S. Food & Drug Administration in 2008 for use in the treatment of lymphoma. Results showed that the drugs, working in tandem, targeted a specific protein to stop cancer cells in the bone marrow from replicating, and eventually causing them to die.
Dr. Alan Lichtenstein, a member of UCLA’s Jonsson Comprehensive Cancer Center and lead author of the study, and colleagues focused on using compound 11 and bortezomib to target a specific oncogene called Myc that is known to have the potential to cause cancer.
“Compound 11 will prevent the transmission of the Myc RNA into Myc protein, and prevent the Myc protein from being synthesized in the multiple myeloma cells when those cell lines are being stressed by the drug bortezomib,” said Lichtenstein, a UCLA professor of hematology and oncology. “Though this research is only in the preliminary phases, we hope that it will eventually lead to human clinical trials and the development of new treatments for this devastating disease.”
The complete study is now available online in the journal Oncogene.
