Evan (Dale) Abel, MD, PhD

Dr. Abel's lab studies insulin, growth factor signaling and metabolism. Although they primarily focus on metabolic disease, their studies in the cardiovascular system will inform the increased risk of thrombosis in cancer, and the metabolic contributions to heart failure, which is increasingly prevalent in cancer survivors. In addition their recently submitted RO1 is focused on understanding the mechanisms of metabolism dysfunction associated fatty liver disease and fibrosis, which is a risk factor for hepatocellular carcinoma.

Chen H, Li K, Li M, Li W, Yu H, Sun X, Zhang Q, Li Y, Li X, Li Y, Abel ED, Wu Q. Airway epithelial regeneration requires autophagy and glucose metabolism. Cell Death and Disease. 2019. 10 (12):875. doi: 10.1038/s41419-019-2111-2. PMC: 6868131

Li X, Wu J, Sun X, Wu Q, Li Y, Li K, Zhang Q, Li Y, Abel ED, Chen H. Autophagy Reprograms Alveolar Progenitor Cell Metabolism in Response to Lung Injury. 2020. Stem Cell Reports. 14(3):420-432. doi: 10.1016/j.stemcr.2020.01.008.an 28. PMC: 7066233

Contat C, Ancey P-B, Zangger N, Sabato S, Pascual J, Escrig S, Jensen L, Goepfert C, Lanz B, Lepore M, Gruetter R, Rossier A, Berezowska S, Neppl C, Zlobec I, Clerc-Rosset S, Knott G, Rathmell JC, Abel ED, Meibom A, Meylan E. Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth. 2020. Elife. 9:e53618. doi: 10.7554/eLife.53618. PMC: 7311173.

Li B, Lee W-C, Song C, Ye L, Abel ED, Long F. Both aerobic glycolysis and mitochondrial respiration are required for osteoclast differentiation. 2020: FASEB J. 34:11058-11067. doi: 10.1096/fj.202000771R. PMC Pending.

Ancey PB, Contat C, Boivin G, Sabatino S, Pascual J, Zangger N, Perentes JY, Peters S, Abel ED, Kirsch DG, Rathmell JC, Vozenin MC Meylan E. Glut1 expression by tumor associated neutrophils promotes lung cancer growth and resistance to radiotherapy. 2021 Cancer Research. 81(9):2345-2357. doi: 10.1158/0008-5472.CAN-20-2870. PMC: 8137580.