Gerald Lipshutz, MD

Gerald Lipshutz, MD, DDS

Professor, Department of Surgery and Department of Molecular and Medical Pharmacology
Physician, Department of Surgery, Liver and Pancreas Transplantation

Languages

English

Specialty

Kidney Transplantation, Liver Transplantation, Pancreas Transplantation, Surgery General

Institutional Affiliation

Ronald Reagan UCLA Medical Center

Education

Fellowship

Solid Organ Transplantation, UC San Francisco School of Medicine, 2004

Internship

General Surgery, UC San Francisco School of Medicine, 1994

Degrees

MD, UCLA School of Medicine, 1993
MS, UCLA Graduate Division, 1986 - 1990
DDS, UCLA School of Dentistry, 1985 - 1989

Residency

General Surgery, UC San Francisco School of Medicine, 2002

Board Certification

Surgery, American Board of Surgery, 2003

Contact Information

Phone

(310) 825-5318 - Adult Liver and Intestinal Transplant Referrals and Patient Appointments
(310) 206-6134 - Pediatric Liver Transplant Referral
(310) 206-3748 - Liver and Pancreas Transplantation Referring Physician
(310) 825-6301 - Liver and Pancreas Transplantation Medical Center Page Operator
(310) 825-6836 - Pancreas Transplant Referral
(310) 794-7788 - Surgery Patient Appointments

Clinical Interests

Oncology, Transplantation in the Elderly, Kidney Transplantation, Liver Transplantation, Pancreas Transplantation, Pediatrics

Scientific Interests

Achieving persistent transgene expression at therapeutic levels is a prerequisite for effective gene therapy for inherited disorders of intracellular or secreted proteins. In adult animals, delivery and expression of genes has resulted in immune responses to the gene product and to vector-associated proteins that limit or abrogate expression. Dr. Gerald Lipshutz's investigations aim to study the immune response to proteins expressed prenatally and on into adulthood, after in utero delivery of viral vectors expressing foreign transgenes. Re-administration of viral vectors during adulthood, after prenatal vector delivery, would allow for augmentation of expression postnatally with the goal of achieving therapeutic levels of gene expression. Understanding the mechanism of this immune unresponsiveness may also be important in the treatment of certain malignancies such as melanoma.

Highlighted Publications

Lipshutz GS, Hiatt J, Ghobrial RM, Farmer DG, Martinez MM, Yersiz H, Gornbein J, Busuttil RW. Outcome of liver transplantation in septuagenarians: a single-center experience. Arch Surg. 2007 Aug;142(8):775-81; discussion 781-4.

Lipshutz GS, Baxter-Lowe LA, Nguyen T, Jones KD, Ascher NL, Feng S. Death from donor-transmitted malignancy despite emergency liver retransplantation. Liver Transpl. 2003 Oct;9(10):1102-7.

Lipshutz GS, Titre D, Brindle M, Bisconte AR, Contag CH, Gaensler KM. Comparison of gene expression after intraperitoneal delivery of AAV2 or AAV5 in utero. Mol Ther. 2003 Jul;8(1):90-8.

Lipshutz GS, Brennan TV, Warren RS. Thorotrast-induced liver neoplasia: a collective review. J Am Coll Surg. 2002 Nov;195(5):713-8. Review.