Hong Zhou, PhD
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Dr. Hong Zhou is the founding director of the Electron Imaging Center for Nanomachines at UCLA and a professor in the Department of Microbiology, Immunology and Molecular Genetics. His group uses innovative cryogenic electron microscopy (cryoEM) and tomography (cryoET) to determine 3D structures of tumor viruses and protein-nucleic acid complexes involved in cancers.
Highlighted Publications
Gong D, Dai X, Jih J, Liu YT, Bi GQ, Sun R*, Zhou ZH*. (2019) DNA-Packing Portal and Capsid- Associated Tegument Complexes in the Tumor Herpesvirus KSHV. Cell. 178(6):1329-1343.e12. doi: 10.1016/j.cell.2019.07.035. PMCID: PMC6753055
Li X, Liu S, Zhang L, Issaian A, Hill RC, Espinosa S, Shi S, Cui Y, Kappel K, Das R, Hansen KC, Zhou ZH*, Zhao R*. 2019. A unified mechanism for intron and exon definition and back-splicing. Nature 573, 375–380 doi:10.1038/s41586-019-1523-6. PMCID: PMC6939996.
Liu, W., Y. Cui, C. Wang, Z. Li, D. Gong, X. Dai, G. Q. Bi, R. Sun and ZH Zhou* (2020). Structures of capsid and capsid-associated tegument complex inside the Epstein-Barr virus. Nat Microbiol 5, 1285-1298, doi:10.1038/s41564-020-0758-1. PMCID: PMC7546529
He, Y., Y. Wang, B. Liu, C. Helmling, L. Susac, R. Cheng, Z.H. Zhou* and J. Feigon* (2021). Structures of telomerase at several steps of telomere repeat synthesis. Nature 593(7859): 454- 459. doi: 10.1038/s41586-021-03529-9. PMID: 33981033.
Zhou K, Si Z, Tso J, Luo M, Zhou ZH* (2022) Atomic model of vesicular stomatitis virus and mechanism of assembly. Nat Commun.13(1):5980. doi: 10.1038/s41467-022-33664-4. PMID: 36216930; PMCID: PMC9549855.