James Economou, MD, PhD

Dr. James Economou coordinates the Human Gene Therapy Program with Dr. William McBride. His research interests include melanoma and hepatoma clinical trials, vector design, in vivo gene transfer and cytokine biology.

Jazirehi AR, Economou JS. Proteasome inhibition blocks NF-kappaB and ERK1/2 pathways, restores antigen expression, and sensitizes resistant human melanoma to TCR-engineered CTLs. Mol Cancer Ther. 2012 Jun;11(6):1332-41. Epub 2012 Apr 24

Narayan R, Nguyen H, Bentow JJ, Moy L, Lee DK, Greger S, Haskell J, Vanchinathan V, Chang PL, Tsui S, Konishi T, Comin-Anduix B, Dauphine C, Vargas HI, Economou JS, Ribas A, Bruhn KW, Craft N. Immunomodulation by imiquimod in patients with high-risk primary melanoma. J Invest Dermatol. 2012 Jan;132(1):163-9. Epub 2011 Aug 18

Quatromoni JG, Wang Y, Vo DD, Morris LF, Jazirehi AR, McBride W, Chatila T, Koya RC, Economou JS. T cell receptor (TCR)-transgenic CD8 lymphocytes rendered insensitive to transforming growth factor beta (TGFBeta) signaling mediate superior tumor regression in an animal model of adoptive cell therapy. J Transl Med. 2012 Jun 19;10:127.

Kachikwu EL, Iwamoto KS, Liao YP, Demarco JJ, Agazaryan N, Economou JS, McBride WH, Schaue D. Radiation enhances regulatory T cell representation. Int J Radiat Oncol Biol Phys. 2011 Nov 15;81(4):1128-35. Epub 2010 Nov 17

Quatromoni JG, Morris LF, Donahue TR, Wang Y, McBride W, Chatila T, Economou JS. T cell receptor transgenic lymphocytes infiltrating murine tumors are not induced to express foxp3. J Hematol Oncol. 2011 Nov 23;4:48.