John S. Adams, MD

Dr. John Adams is Director of the Orthopaedic Hospital Research Center, where he is charged with building an interschool (the College and School of Medicine), multidisciplinary program of research in musculoskeletal sciences. His bench-to-bedside (translational) and clinical research efforts are targeted at understanding

1. the concerted role of heterogeneous nuclear ribonucleoproteins and heat shock proteins in hormone-directed chromatin remodeling, transcription, transcript splicing and miRNA regulation of mRNA handling,
2. the role of vitamin D in the human innate and adaptive immune response, and
3. the contribution of human vitamin D insufficiency to states of immuno-insufficiency and abnormal skeletal and energy homeostasis.

Hokugo A, Christensen R, Chung EM, Sung EC, Felsenfeld AL, Sayre JW, Garrett N, Adams JS, Nishimura I. Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats. J Bone Miner Res. 2010 Jun;25(6):1337-49.

Geller JL, Khosravi A, Kelly MH, Riminucci M, Adams JS, Collins MT. Cinacalcet in the management of tumor-induced osteomalacia. J Bone Miner Res. 2007 Jun;22(6):931-7.

Evans KN, Taylor H, Zehnder D, Kilby MD, Bulmer JN, Shah F, Adams JS, Hewison M. Increased expression of 25-hydroxyvitamin D-1alpha-hydroxylase in dysgerminomas: a novel form of humoral hypercalcemia of malignancy. Am J Pathol. 2004 Sep;165(3):807-13.

Hewison M, Kantorovich V, Liker HR, Van Herle AJ, Cohan P, Zehnder D, Adams JS. Vitamin D-mediated hypercalcemia in lymphoma: evidence for hormone production by tumor-adjacent macrophages. J Bone Miner Res. 2003 Mar;18(3):579-82.

Adams JS, Fernandez M, Gacad MA, Gill PS, Endres DB, Rasheed S, Singer FR. Vitamin D metabolite-mediated hypercalcemia and hypercalciuria patients with AIDS- and non-AIDS-associated lymphoma. Blood. 1989 Jan;73(1):235-9.