Linh Tran, PhD

Linh Tran, PhD

Associate Professor, Department of Medicine, Division of Pulmonary and Critical Care

Languages

English

Education

Fellowships

Genetics/Biostatistics, Rosetta LLC, Seattle, WA, 2009
Cancer Biology, University of California, Los Angeles, CA, 2013

Degrees

PhD, University of California, Los Angeles, CA, 2008
BS, University of California, Los Angeles, CA, 2002

Contact Information

Scientific Interests

Dr. Tran is an Associate Professor in the Department of Medicine in the David Geffen School of Medicine at UCLA with expertise and training in computational biology. Her research focuses on the early development of lung cancer. Dr. Tran studies genetic and microenvironment alteration associated with transformation from premalignancy to malignancy in non-small cell lung cancer. Her projects also aim to identify markers for early detection of lung cancer from liquid biopsy and CT images.

Highlighted Publications

Dost AFM, Moye AL, Vedaie M, Tran LM, Fung E, Heinze D, Villacorta-Martin C, Huang J, Hekman R, Kwan JH, Blum BC, Louie SM, Rowbotham SP, Sainz de Aja J, Piper ME, Bhetariya PJ, Bronson RT, Emili A, Mostoslavsky G, Fishbein GA, Wallace WD, Krysan K, Dubinett SM, Yanagawa J, Kotton DN, Kim CF. Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells. Cell Stem Cell. 2020 Oct 1;27(4):663-678.e8. PubMed PMID: 32891189; PubMed Central PMCID: PMC7541765.

Li R, Salehi-Rad R, Crosson W, Momcilovic M, Lim RJ, Ong SL, Huang ZL, Zhang T, Abascal J, Dumitras C, Jing Z, Park SJ, Krysan K, Shackelford DB, Tran LM, Liu B, Dubinett SM. Inhibition of Granulocytic Myeloid-Derived Suppressor Cells Overcomes Resistance to Immune Checkpoint Inhibition in LKB1-Deficient Non-Small Cell Lung Cancer. Cancer Res. 2021 Jun 15;81(12):3295-3308. doi: 10.1158/0008-5472.CAN-20- 3564. Epub 2021 Apr 14. PubMed PMID: 33853830; PubMed Central PMCID: PMC8776246

Salehi-Rad R*, Li R*, Tran LM*, Lim RJ, Abascal J, Momcilovic M, Park SJ, Ong SL, Shabihkhani M, Huang ZL, Paul M, Shackelford DB, Krysan K, Liu B, Dubinett SM. Novel Kras-mutant murine models of non-small cell lung cancer possessing co-occurring oncogenic mutations and increased tumor mutational burden. Cancer Immunol Immunother. 2021 Aug;70(8):2389-2400. doi: 10.1007/s00262-020-02837-9. Epub 2021 Jan 28. PubMed PMID: 33507343; PubMed Central PMCID: PMC8289771.

Salehi-Rad R, Lim RJ, Du Y, Tran LM, Li R, Ong SL, Ling Huang Z, Dumitras C, Zhang T, Park SJ, Crosson W, Kahangi B, Abascal J, Seet C, Oh M, Shabihkhani M, Paul M, Krysan K, Lisberg AE, Garon EB, Liu B, Dubinett SM. CCL21-DC in situ vaccination in murine NSCLC overcomes resistance to immunotherapy and generates systemic tumorspecific immunity. J Immunother Cancer. 2023 Sep;11(9). doi: 10.1136/jitc-2023-006896. PubMed PMID: 37730274; PubMed Central PMCID: PMC10510892.

Yanagawa J*, Tran LM*, Salehi-Rad R, Lim RJ, Dumitras C, Fung E, Wallace WD, Prosper AE, Fishbein G, Shea C, Hong R, Kahangi B, Deng JJ, Gower AC, Liu B, Campbell JD, Mazzilli SA, Beane JE, Kadara H, Lenburg ME, Spira AE, Aberle DR, Krysan K, Dubinett SM. Single-Cell Characterization of Pulmonary Nodules Implicates Suppression of Immunosurveillance across Early Stages of Lung Adenocarcinoma. Cancer Res. 2023 Oct 2;83(19):3305-3319. doi: 10.1158/0008-5472.CAN-23-0128. PubMed PMID: 37477508; PubMed Central PMCID: PMC10544016.