Mehdi Bouhaddou, PhD
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The Bouhaddou lab attempts to better understand and predict the behavior of signaling networks, with relevance to network-guided precision oncology. Many targeted therapies fail to induce a durable response due to signaling compensation or insufficient oncogene shutoff, both of which require a deeper understanding of signaling network interconnectivity and function. The Bouhaddou lab uses mass spectrometry proteomics and computational modeling to identify the protein-protein interactions and post-translational modifications that dictate signaling pathway connectivity—How does pathway A activate pathway B in a specific cellular context? In addition, in collaboration with the University of Ghana, the Bouhaddou lab studies how HIV and HPV cooperate to drive advanced cervical cancer in co-infected African women with the goal of developing HIV-specific therapeutic approaches to treat cervical cancer.
Highlighted Publications
Bouhaddou, Mehdi; Yu, Li J; Lunardi, Serena; Stamatelos, Spyros K; Mack, Fiona; Gallo, James M; Birtwistle, Marc R; Walz, Antje-Christine. Predicting in vivo efficacy from in vitro data: quantitative systems pharmacology modeling for an epigenetic modifier drug in cancer. Clinical and translational science (2020).
Kim, Minkyu; Park, Jisoo; Bouhaddou, Mehdi; Kim, Kyumin; Rojc, Ajda; Modak, Maya; Soucheray, Margaret; McGregor, Michael J; O’Leary, Patrick; Wolf, Denise; et al. A protein interaction landscape of breast cancer. Science (2021).
Bouhaddou, Mehdi; Lee, Rex H; Li, Hua; Bhola, Neil E; O’Keefe, Rachel A; Naser, Mohammad; Zhu, Tian Ran; Nwachuku, Kelechi; Duvvuri, Umamaheswar; Olshen, Adam B; et al. Caveolin 1 and Sox-2 are predictive biomarkers of cetuximab response in head and neck cancer. JCI insight (2021).
Swaney, Danielle L; Ramms, Dana J; Wang, Zhiyong; Park, Jisoo; Goto, Yusuke; Soucheray, Margaret; Bhola, Neil; Kim, Kyumin; Zheng, Fan; Zeng, Yan; Bouhaddou, Mehdi; et al. A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity. Science (2021).
Ochieng’Olwal, Charles; Fabius, Jacqueline M; Zuliani-Alvarez, Lorena; Eckhardt, Manon; Kyei, George Boateng; Quashie, Peter Kojo; Krogan, Nevan J; Bouhaddou, Mehdi; Bediako, Yaw. Network modeling suggests HIV infection phenocopies PI3K-AKT pathway mutations to enhance HPV-associated cervical cancer. Molecular Omics (2023).