Nicholas G. Nickols, MD, PhD
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Scientific Interests
Dr. Nicholas Nickols is interested in exploring a chemical biology approach to modulation of ionizing radiotherapy, overcoming treatment resistance mechanisms and conducting combined therapy clinical trials for locally advanced prostate cancer.
Highlighted Publications
Nickols NG, Szablowski JO, Hargrove AE, Li BC, Raskatov JA, Dervan PB. Activity of a Py-Im polyamide targeted to the estrogen response element. Mol Cancer Ther. 2013 May;12(5):675-84. doi: 10.1158/1535-7163.MCT-12-1040. Epub 2013 Feb 26.
Yang F, Nickols NG, Li BC, Marinov GK, Said JW, Dervan PB. Antitumor activity of a pyrrole-imidazole polyamide. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1863-8. doi: 10.1073/pnas.1222035110. Epub 2013 Jan 14.
Nickols NG, Dervan PB. Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10418-23. Epub 2007 Jun 12.
Nickols NG, Jacobs CS, Farkas ME, Dervan PB. Modulating hypoxia-inducible transcription by disrupting the HIF-1-DNA interface. ACS Chem Biol. 2007 Aug 17;2(8):561-71.
