Samuel French, MD, PhD
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Scientific Interests
Dr. Samuel French studies hepatitis C viral mediated hepatocarcinogenesis, primarily focusing on a proteomic approach to determine how specific viral proteins subvert normal hepatocyte signaling. He is also interested in identifying gene expression changes seen in early hepatocyte dysplasia.
Highlighted Publications
Khachatoorian R, Riahi R, Ganapathy E, Shao H, Wheatley NM, Sundberg C, Jung CL, Ruchala P, Dasgupta A, Arumugaswami V, Gestwicki JE, French SW. Allosteric heat shock protein 70 inhibitors block hepatitis C virus assembly. Int J Antimicrob Agents. 2016 Apr;47(4):289-96. doi: 10.1016/j.ijantimicag.2016.01.012. Epub 2016 Mar 2.
Uthaya Kumar DB, Chen CL, Liu JC, Feldman DE, Sher LS, French S, DiNorcia J, French SW, Naini BV, Junrungsee S, Agopian VG, Zarrinpar A, Machida K. TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice. Gastroenterology. 2016 Mar;150(3):707-19. doi: 10.1053/j.gastro.2015.11.002. Epub 2015 Nov 12.
Lu NT, Crespi CM, Liu NM, Vu JQ, Ahmadieh Y, Wu S, Lin S, McClune A, Durazo F, Saab S, Han S, Neiman DC, Beaven S, French SW. A Phase I Dose Escalation Study Demonstrates Quercetin Safety and Explores Potential for Bioflavonoid Antivirals in Patients with Chronic Hepatitis C. Phytother Res. 2016 Jan;30(1):160-8. doi: 10.1002/ptr.5518. Epub 2015 Dec 1.
Buzzanco A, Gomez A, Rodriguez E, French BA, Tillman BA, Chang S, Ganapathy E, Junrungsee S, Zarrinpar A, Agopian VG, Naini BV, French SW Jr, French SW Sr. Digital quantitation of HCC-associated stem cell markers and protein quality control factors using tissue arrays of human liver sections. Exp Mol Pathol. 2014 Dec;97(3):399-410. doi: 10.1016/j.yexmp.2014.09.002. Epub 2014 Sep 8.
Khachatoorian R, Ruchala P, Waring A, Jung CL, Ganapathy E, Wheatley N,Sundberg C, Arumugaswami V, Dasgupta A, French SW. Structural characterization of the HSP70 interaction domain of the hepatitis C viral protein NS5A. Virology. 2015 Jan 15;475:46-55. doi: 10.1016/j.virol.2014.10.011. Epub 2014 Nov 25.
