Steven-Huy Han, MD, FAASLD, AGAF

Dr. Han's research interests are: 1) Development of serum biomarkers for the early detection of hepatocellular carcinoma in at-risk populations including cirrhotic patients and patients with chronic hepatitis B infection. Specifically, he is a co-PI in the NCI U01 Translational Liver Cancer (TLC) Consortium charged with developing methodologies for the early detection of HCC. One specific objective of the TLC is developing a large serum biorepository and database of at-risk patients for longitudinal study. 2) Studying the pathophysiology of hepatitis B-related HCC to try to elucidate the relationship between hepatitis B virologic states, serum biomarkers, and propensity towards HCC development. And 3) Studying the relationship between MR imaging of pre-HCC lesions, serum biomarkers, and propensity towards HCC development.

Han S-H, Reddy KR, Keeffe EB, Soldevila-Pico C, Gish R, Chung RT, Degertekin B, Lok A, “Clinical Outcomes of Liver Transplantation for HBV-Related Hepatocellular Carcinoma: Data from the NIH HBV-OLT Study”. Clin Transplant 2011 Mar-Apr; 25(2): E152-62. One of my initial articles looking at HCV-related HCC .

Sun N, Lee YT, Kim M, Wang JJ, Zhang C, Teng PC, Qi D, Zhang RY, Tran BV, Lee YT, Ye J, Palomique J, Nissen NN, Han S-H, Sadeghi S, Finn RS, Saab S, Busuttil RW, Posadas EM, Liang L, Pei R, Yang JD, You S, Agopian VG, Tseng HR, Zhu Y. “Covalent Chemistry-Mediated Multimarker Purification of Circulating Tumor Cells Enables Noninvasive Detection of Molecular Signatures of Hepatocellular Carcinoma”. Adv Mater Technol. 2021 May;6(5):2001056. PMID: 34212072.

Lee Y-T, Sun N, Kim M, Wang JJ, Tran BV, Zhang RY, Qi D, Zhang C, Chen P-J, Sadeghi S, Finn R, Saab S, Han S-H, Busuttil RW, Pei R, Zhu Y, Tseng H-R, You S, Yang JD, Agopian VG. “Circulating Tumor Cell-Based Messenger RNA Scoring System for Prognostication of Hepatocellular Carcinoma: Translating Tissue-Based Messenger RNA Profiling Into a Noninvasive Setting”. Liver Transpl. 2022 Feb;28(2):200-214. doi: 10.1002/lt.26337. Epub 2021 Nov 16. PMID: 34664394

Sun N, Zhang C, Lee YT, Tran BV, Wang J, Kim H, Lee J, Zhang RY, Wang JJ, Hu J, Zhang Z, Alsudaney MS, Hou KC, Tang H Liang IY Zhou Z Chen M Yeh AH Li W Zhou XJ Chang HR Han S-H Sadeghi S Finn RS Saab S Busuttil RW Noureddin M Ayoub WS Kuo A Sundaram V Al-Ghaieb B Palomique J Kosari K Kim IK Todo T Nissen NN Tomasi ML You S Posadas EM Wu JX Wadehra M Sim MS Li Y Wang HL French SW Lu SC Wu L Pei R Liang L Yang JD Agopian VG Tseng HR Zhu Y. “HCC EV ECG score: An extracellular vesicle-based protein assay for detection of early-stage hepatocellular carcinoma”. Hepatology. 2022 Jul 31. doi: 10.1002/hep.32692. Online ahead of print. PMID: 35908246"

Stackpole ML, Zeng W, Li S, Liu CC, Zhou Y, He S, Yeh A, Wang Z, Sun F, Li Q, Yuan Z, Yildirim A, Chen PJ, Winograd P, Tran B, Lee YT, Li PS, Noor Z, Yokomizo M, Ahuja P, Zhu Y, Tseng HR, Tomlinson JS, Garon E, French S, Magyar CE, Dry S, Lajonchere C, Geschwind D, Choi G, Saab S, Alber F, Wong WH, Dubinett SM, Aberle DR, Agopian V, Han S-H, Ni X, Li W, Zhou XJ. “Cost-effective methylome sequencing of cell-free DNA for accurately detecting and locating cancer”. Nat Commun. 2022 Sep 29;13(1):5566. doi: 10.1038/s41467-022-32995-6. PMID: 36175411