Tikvah Hayes, PhD

Tikvah (Tiki) Hayes, PhD

Assistant Professor, Department of Molecular and Medical Pharmacology

Languages

English

Education

Fellowship

Cancer Biology and Genomics, Harvard Medical School, Boston, MA, 2021

Degrees

PhD, University of North Carolina, Chapel Hill, NC, 2016
BA, University of California, San Diego, 2005
BS, University of California, San Diego, 2005

Contact Information

Scientific Interests

Dr. Tiki Hayes’s research program broadly focuses on basic and pre-clinical mechanisms surrounding oncogene dependency, signal transduction, and therapeutic strategies. Identifying and understanding of variants of unknown significance (VUS) and development of resistance to targeted therapies represent two significant challenges facing current cancer care. Dr. Hayes is particularly interested in 1) interrogating oncogenic dependency and signal transduction networks, 2) assessing mechanisms driving therapeutic sensitivity/resistance, and 3) characterizing somatic variants of unknown significance. She addresses these questions using a combination of high-throughput genetic screening and molecular biology and pharmacology.

Highlighted Publications

Persky NS, Hernandez D, Do Carmo M, Brenan L, Cohen O, Kitajima S, Nayar U, Walker A, Pantel S, Lee Y, Cordova J, Sathappa M, Zhu C, Hayes TK, Ram P, Pancholi P, Mikkelsen TS, Barbie DA, Yang X, Haq R, Piccioni F, Root DE, Johannessen CM. Defining the landscape of ATP-competitive inhibitor resistance residues in protein kinases. Nat Struct Mol Biol 27(1), 92–104 (2020). PMID: 31925410

Hayes TK, Luo F, Cohen O, Goodale AB, Lee Y, Pantel S, Bagul M, Piccioni F, Root DE, Garraway LA, Meyerson M, Johannessen CM. A Functional Landscape of Resistance to MEK1/2 and CDK4/6 Inhibition in NRAS-Mutant Melanoma. Cancer Res. May 1;79(9):2352-2366. PMID: 30819666

Hayes TK, Neel NF, Hu C, Gautam P, Chenard M, Long B, Aziz M, Kassner M, Bryant KL, Pierobon M, Marayati R, Kher S, George SD, Xu M, Wang-Gillam A, Samatar AA, Maitra A, Wennerberg K, Petricoin EF 3rd, Yin HH, Nelkin B, Cox AD, Yeh JJ, Der CJ. Long-Term ERK Inhibition in KRAS Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression. Cancer Cell. 2016 Jan 11;29 (1):75-89. PMCID: PMC4816652