Ting-Ting Wu, PhD

Dr. Ting-Ting Wu's primary research interest is to understand how tumor-associated herpesviruses evade the host defense. Her lab studies the molecular mechanisms and cellular pathways that the virus exploits to down-regulate type I interferon responses. Her goal is to manipulate these viral immune evasion mechanisms for rational design of safe, highly attenuated viruses to be used as vaccines with the ability to elicit robust adaptive immune responses for cancer.

Dai X, Gong D, Lim H, Jih J, Wu TT, Sun R, Zhou ZH. Structure and mutagenesis reveal essential capsid protein interactions for KSHV replication. Nature. 2018 Jan 25;553(7689):521-525. doi: 10.1038/nature25438. Epub 2018 Jan 17.

Qi H, Chu V, Wu NC, Chen Z, Truong S, Brar G, Su SY, Du Y, Arumugaswami V, Olson CA, Chen SH, Lin CY, Wu TT, Sun R. Systematic identification of anti-interferon function on hepatitis C virus genome reveals p7 as an immune evasion protein. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2018-2023. doi: 10.1073/pnas.1614623114. Epub 2017 Feb 3.

Gong D, Dai X, Xiao Y, Du Y, Chapa TJ, Johnson JR, Li X, Krogan NJ, Deng H, Wu TT, Sun R. Virus-Like Vesicles of Kaposi's Sarcoma-Associated Herpesvirus Activate Lytic Replication by Triggering Differentiation Signaling. J Virol. 2017 Jul 12;91(15). pii: e00362-17. doi: 10.1128/JVI.00362-17. Print 2017 Aug 1.

Du Y, Chi X, Wang C, Jiang J, Kong F, Yan H, Wang X, Li J, Wu NC, Dai L, Zhang TH, Shu S, Zhou J, Yoshizawa JM, Li X, Bhattacharya D, Wu TT, Niu J, Sun R. Quantifying perinatal transmission of Hepatitis B viral quasispecies by tag linkage deep sequencing. Sci Rep. 2017 Aug 31;7(1):10168. doi: 10.1038/s41598-017-10591-9.

Gong D, Kim YH, Xiao Y, Du Y, Xie Y, Lee KK, Feng J, Farhat N, Zhao D, Shu S, Dai X, Chanda SK, Rana TM, Krogan NJ, Sun R, Wu TT. A Herpesvirus Protein Selectively Inhibits Cellular mRNA Nuclear Export. Cell Host Microbe. 2016 Nov 9;20(5):642-653. doi: 10.1016/j.chom.2016.10.004.