Banerjee, Zargari, Medzikovic, Russino, Mikhael, Grogan, Rahman, Eghbali and Umar: Intralipid® improves left ventricular function in rats with lipopolysaccharide-induced endotoxaemia by a Src-STAT3-mediated mechanism
Soban Umar, MD, PhD and Somanshu Banerjee, PhD
Published on December 1, 2022
Editor—Sepsis-induced cardiomyopathy contributes to significant morbidity and mortality worldwide. Despite recent advances, the pathophysiology of septic shock is complex and difficult to treat. Intralipid® mitigates the cardiodepressant effects of local anaesthetics and ischaemia/reperfusion injury via improved metabolic function and activation of cardioprotective signalling cascades, however its role in sepsis-induced cardiac dysfunction is unknown.
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