Publications
Selected Publications - Jacobs NCBI Bibliography
Yang JC, Zhao M, Chernikova D, Arias-Jayo N, Zhou Y, Situ J, Gutta A, Chang C, Liang F, Lagishetty V, Jacobs JP. ZIP8 A391T Crohn's Disease-Linked Risk Variant Induces Colonic Metal Ion Dyshomeostasis, Microbiome Compositional Shifts, and Inflammation. Dig Dis Sci. 2024 Sep 25. [PMID: 39322808]
Jacobs JP, Spencer EA, Helnus DS, Yang JC, Lagishetty V, Bongers G, Britton GJ, Gettler K, Reyes-Mercedes P, Hu J, Hart A, Lamousé-Smith E, Wehkamp J, Landers C, Debbas P, Torres J, Colombel JF, Cho J, Peter I, Faith J, Braun J, Dubinsky MC. Age-related patterns of microbial dysbiosis in multiplex inflammatory bowel disease families. Gut. 2024 Aug 9:gutjnl-2024-332475. [PMID: 39122361]
Shera S, Katzka W, Yang JC, Chang C, Arias-Jayo N, Lagishetty V, Balioukova A, Chen Y, Dutson E, Li Z, Mayer EA, Pisegna JR, Sanmiguel C, Pawar S, Zhang D, Leitman M, Hernandez L, Jacobs JP, Dong TS. Bariatric-induced microbiome changes alter MASLD development in association with changes in the innate immune system. Front Microbiol. 2024 Aug 9;15:1407555. [PMID: 39184030]
Dong TS, Peters K, Gupta A, Jacobs JP, UCLA SCORE Group in IBS and Sex Differences, Chang L. Prevotella Is Associated with Sex-Based Differences in Irritable Bowel Syndrome. Gastroenterology. 2024 Jul 12;. doi: 10.1053/j.gastro.2024.07.006. [PMID: 39004155]
Chang C, Louie A, Zhou Y, Gupta R, Liang F, Xanthou G, Ereso J, Koletic C, Yang JC, Sedighian F, Lagishetty V, Arias-Jayo N, Altuwayjiri A, Tohidi R, Navab M, Reddy ST, Sioutas C, Hsiai T, Araujo JA, Jacobs JP. Ambient Particulate Matter Induces In Vitro Toxicity to Intestinal Epithelial Cells without Exacerbating Acute Colitis Induced by Dextran Sodium Sulfate or 2,4,6-Trinitrobenzenesulfonic Acid. Int J Mol Sci. 2024 Jun 29;25(13). [PMID: 39000289]
Shin DS, Basak S, Veena MS, Comin-Anduix B, Bhattacharya A, Dong TS, Ko A, Han P, Jacobs J, Moatamed NA, Avila L, Pellegrini M, Wang M, Srivatsan ES. Enhanced CTLA-4 blockade anti-tumor immunity with APG-157 combination in a murine head and neck cancer. Cancer Med. 2024 May;13(9):e7212. [PMID: 38686626]
Chang C, Gupta R, Sedighian F, Louie A, Gonzalez DM, Le C, Cho JM, Park SK, Castellanos J, Ting TW, Dong TS, Arias-Jayo N, Laghishetty V. Navab M, Reddy S, Sioutas C, Hsiai T, Jacobs JP and Aaraujo JA. Subchronic inhalation exposure to ultrafine particle matter alters the intestinal microbiome in various mouse models. Environ Res. 2024 May 1:248:118242
Kwon D, Zhang K, Paul KC, Folle AD, Del Rosario I, Jacobs JP, Keener AM, Bronstein JM, Ritz B. Diet and the gut microbiome in patients with Parkinson's disease. NPJ Parkinsons Dis. 2024 Apr 22;10(1):89. [PMID: 38649365]
Zhang K, Paul K, Jacobs JP, Cockburn MG, Bronstein JM, Del Rosario I, Ritz B. Ambient long-term exposure to organophosphorus pesticides and the human gut microbiome: An observational study. Environ Health. 2024 Apr 16;23(1):41. [PMID: 38627687]
Wiley KS, Gregg AM, Fox MM, Lagishetty, Sandman CA, Jacobs JP, Glyenn LM. Contact with caregivers is associated with composition of the inflant gastrointestinal microbiome in the first 6 months of life. American Journal of Biological Anthropology. April 2024
Andréasson K, Olofsson T, Lagishetty V, Alrawi Z, Klaassens E, Holster S, Hesselstrand R, Jacobs JP, Wallman JK, Volkmann ER. Treatment for Rheumatoid Arthritis Associated With Alterations in the Gastrointestinal Microbiota. ACR Open Rheumatol. 2024 Apr 23. [PMID: 38653503]
Ye X, Ghosh S, Shin BC, Ganguly A, Maggiotto L, Jacobs JP, Devaskar SU. Brain serotonin and serotonin transporter expression in male and female postnatal rat offspring in response to perturbed early life dietary exposures. Front Neurosci. 2024 Mar 21;18:1363094. [PMID: 38576870]
Kim MJ, Kim HN, Jacobs JP, Yang HJ. Combined DNA Methylation and Gastric Microbiome Marker Predicts Helicobacter pylori-Negative Gastric Cancer. Gut Liver. 2024 Mar 21. doi: 10.5009/gnl230348. Online ahead of print. [PMID: 38509701]
Chang C, Gupta R, Sedighian F, Louie A, Gonzalez D, Le C, Cho JM, Park SK, Castellanos J, Ting TW, Dong TS, Arias-Jayo N, Lagishetty V, Navab M, Reddy S, Sioutas C, Hsiai T, *Jacobs JP, *Araujo JA. Subchronic inhalation exposure to ultrafine particulate matter alters the intestinal microbiome in various mouse models. Environ Res. 2024 Jan 17:118242. [PMID: 38242419] *Co-senior authors
Wiley KS, Gregg AM, Fox MM, Lagishetty V, Sandman CA, *Jacobs JP, *Glynn LM. Contact with caregivers is associated with composition of the infant gastrointestinal microbiome in the first 6 months of life. Am J Biol Anthropol. 2023 Oct 7. [PMID: 37804008] *Co-senior authors
Caremoli F, Huynh J, Lagishetty V, Markovic D, Braun J, Dong TS, Jacobs JP, Sternini C. Microbiota-Dependent Upregulation of Bitter Taste Receptor Subtypes in the Mouse Large Intestine in High-Fat Diet-Induced Obesity. Nutrients. 2023 Sep 25;15(19):4145. [PMID: 37836428]
Jacobs JP, Sauk JS, Ahdoot AI, Liang F, Katzka W, Ryu HJ, Khandadash A, Lagishetty V, Labus JS, Naliboff BD, Mayer EA. Microbial and Metabolite Signatures of Stress Reactivity in Ulcerative Colitis Patients in Clinical Remission Predict Clinical Flare Risk. Inflamm Bowel Dis. 2023 Aug 31. [PMID: 37650887]
Jacobs JP, Lee ML, Rechtman DJ, Sun AK, Autran C, Niklas V. Human milk oligosaccharides modulate the intestinal microbiome of healthy adults. Sci Rep. 2023 Aug 31;13(1):14308. [PMID: 37652940]
Lee JT, Simpson CA, Yang HH, Suh JD, Wang MB, Lagishetty V, Liang F, Jacobs JP. Fungal and Bacterial Microbiome in Sinus Mucosa of Patients with and without Chronic Rhinosinusitis. Laryngoscope. 2023 Aug 22. [PMID: 37606305]
Yang JC, Troutman R, Buri H, Gutta A, Situ J, Aja E, Jacobs JP. Ileal Dysbiosis Is Associated with Increased Acoustic Startle in the 22q11.2 Microdeletion Mouse Model of Schizophrenia. Nutrients. 2023 Aug 18;15(16). [PMID: 37630824]
Zhao M, Jacobs JP. Fecal matters: Microbial signatures distinguish clinically relevant subtypes of precancerous colorectal polyps. Cell Host Microbe. 2023 May 10;31(5):692-694. [PMID: 37167951]
Cuff C, Lin LD, Mahurkar-Joshi S, Jacobs JP, Lagishetty V, Jaffe N, Smith J, Dong T, Sohn J, Chang L. Randomized controlled pilot study assessing fructose tolerance during fructose reintroduction in non-constipated irritable bowel syndrome patients successfully treated with a low FODMAP diet. Neurogastroenterol Motil. 2023 Apr 13;e14575. [PMID: 37052402]
Chattopadhyay A, Mukherjee P, Sulaiman D, Wang H, Girjalva V, Dorreh N, Jacobs JP, Delk S, Moolenaar WH, Navab M, Reddy ST, Fogelman AM. Role of Enterocyte Enpp2 and Autotaxin in Regulating Lipopolysaccharide Levels, Systemic Inflammation and Atherosclerosis. J Lipid Res. 2023 Apr 12;100370. [PMID: 37059333]
Nguyen AD, Andréasson K, McMahan ZH, Bukiri H, Howlett N, Lagishetty V, Lee SM, Jacobs JP, Volkmann ER. Gastrointestinal tract involvement in systemic sclerosis: The roles of diet and the microbiome. Semin Arthritis Rheum. 2023 Feb 24;60:152185. [PMID: 36870237]
Yang J, Lee R, Schulz Z, Hsu A, Pai J, Yang S, Henning SM, Huang J, Jacobs JP, Heber D, Li Z. Mixed Nuts as Healthy Snacks: Effect on Tryptophan Metabolism and Cardiovascular Risk Factors. Nutrients. 2023 Jan 21; 15(3): 569. [PMID: 36771274]
Jacobs JP, Lagishetty V, Hauer MC, Labus JS, Dong TS, Toma R, Vuyisich M, Naliboff BD, Lackner JM, Gupta A, Tillisch K, Mayer EA. Multi-omics profiles of the intestinal microbiome in irritable bowel syndrome and its bowel habit subtypes. Microbiome. 2023 Jan 10;11(1):5. [PMID: 36624530]
Luu K, Ye JY, Lagishetty V, Liang F, Hauer M, Sedighian F, Kwaan MR, Kazanjian KK, Hecht JR, Lin AY, Jacobs JP. Fecal and Tissue Microbiota Are Associated with Tumor T-Cell Infiltration and Mesenteric Lymph Node Involvement in Colorectal Cancer. Nutrients. 2023 Jan 9;15(2). [PMID: 36678187]
Yang JC, Jacobs JP, Hwang M, Sabui S, Liang F, Said HM, Skupsky J. Biotin Deficiency Induces Intestinal Dysbiosis Associated with an Inflammatory Bowel Disease-like Phenotype. Nutrients. 2023 Jan 4;15(2). [PMID: 36678135]
Dong TS, Katzka W, Yang JC, Chang C, Arias-Jayo N, Lagishetty V, Balioukova A, Chen Y, Dutson E, Li Z, Mayer EA, Pisegna JR, Sanmiguel C, Jacobs JP. Microbial changes from bariatric surgery alters glucose-dependent insulinotropic polypeptide and prevents fatty liver disease. Gut Microbes. 2023 Jan-Dec;15(1):2167170. [PMID: 36732495]
Maggiotto LV, Ghosh S, Shin BC, Ganguly A, Lagishetty V, Jacobs JP, Devaskar SU. Variation in the Early Life and Adult Intestinal Microbiome of Intra-Uterine Growth Restricted Rat Offspring Exposed to a High Fat and Fructose Diet. Nutrients. 2023 Jan 1;15(1). [PMID: 36615874]
Chernikova DA, Zhao MY, Jacobs JP. Microbiome Therapeutics for Food Allergy. Nutrients. 2022 Dec 3;14(23):5155. [PMID: 36501184]
Kim HN, Kim MJ, Jacobs JP, Yang HJ. Altered Gastric Microbiota and Inflammatory Cytokine Responses in Patients with Helicobacter pylori-Negative Gastric Cancer. Nutrients. 2022 Nov 23;14(23):4981. [PMID: 36501012]
Kim CE, Yoon LS, Michels KB, Tranfield W, Jacobs JP, May FP. The Impact of Prebiotic, Probiotic, and Synbiotic Supplements and Yogurt Consumption on the Risk of Colorectal Neoplasia among Adults: A Systematic Review. Nutrients. 2022 Nov 21;14(22):4937. [PMID: 36432622]
Zhang K, Paul KC, Jacobs JP, Chou HL, Folle AD, Del Rosario I, Yu Y, Bronstein JM, Keener AM, Ritz B. Parkinson's Disease and the Gut Microbiome in Rural California. J Parkinsons Dis. 2022;12(8):2441-2452. [PMID: 36442206]
Gong J, Thomassian S, Kim S, Gresham G, Moshayedi N, Ye JY, Yang JC, Jacobs JP, Lo S, Nissen N, Gaddam S, Tighiouart M, Osipov A, Hendifar A. Phase I trial of Bermekimab with nanoliposomal irinotecan and 5-fluorouracil/folinic acid in advanced pancreatic ductal adenocarcinoma. Sci Rep. 2022 Sep 2;12(1):15013. [PMID: 36056179]
Jacobs JP, Goudarzi M, Lagishetty V, Li D, Mak T, Tong M, Ruegger P, Haritunians T, Landers C, Fleshner P, Vasiliauskas E, Ippoliti A, Melmed G, Shih D, Targan S, Borneman J, Fornace AJ Jr, McGovern DPB, Braun J. Crohn's disease in endoscopic remission, obesity, and cases of high genetic risk demonstrate overlapping shifts in the colonic mucosal-luminal interface microbiome. Genome Med. 2022 Aug 15;14(1):91. [PMID: 35971134]
Hendifar A, Akinsola R, Muranaka H, Osipov A, Thomassian S, Moshayedi N, Yang JC, Jacobs JP, Devkota S, Bhowmick N, Gong J. The gut microbiome and pancreatic cancer cachexia: An evolving relationship. World J Gastrointest Oncol. 2022; 14(7): 1218-1226. [PMID: 36051103]
Jacobs JP, Goudarzi M, Lagishetty V, Li D, Mak T, Tong M, Ruegger P, Haritunians T, Landers C, Flesher P, Vasiliauska E, Ippoliti A, Melmed G, Shih D, Targan S, Borneman J, Fornace Jr AJ, McGovern DPB, Braun J. Crohn's disease in endoscopic remission, obesity, and cases of high genetic risk demonstrate overlapping shifts in the colonic mucosal-luminal interface microbiome. Genome Medicine. 15 August 2022
Sauk JS, Ryu HJ, Labus JS, Khandadash A, Ahdoot AI, Lagishetty V, Katzka W, Wang H, Naliboff B, Jacobs JP, Mayer EA. High Perceived Stress is Associated with Increased Risk of Ulcerative Colitis Clinical Flares. Clin Gastroenterol Hepatol. 2022 Aug 8;S1542-3565(22)00721-2. doi: 10.1016/j.cgh.2022.07.025. Online ahead of print. [PMID: 35952942]
Medel-Matus JS, Simpson CA, Ahdoot AI, Shin D, Sankar R, Jacobs JP, Mazarati AM. Modification of post-traumatic epilepsy by fecal microbiota transfer. Epilepsy Behav. 2022 Sep;134:108860. [PMID: 35914438]
Choo C, Mahurkar-Joshi S, Dong TS, Lenhart A, Lagishetty V, Jacobs JP, Labus JS, Jaffe N, Mayer EA, Chang L. Colonic mucosal microbiota is associated with bowel habit subtype and abdominal pain in patients with irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol. 2022 Aug 1;323(2):G134-G143. [PMID: 35726867]
Dong TS, Guan M, Mayer EA, Stains J, Liu C, Vora P, Jacobs JP, Lagishetty V, Chang L, Barry RL, Gupta A. Obesity is associated with a distinct brain-gut microbiome signature that connects Prevotella and Bacteroides to the brain's reward center. Gut Microbes. 2022 Jan-Dec;14(1):2051999. [PMID: 35311453]
Bae SS, Dong TS, Wang J, Lagishetty V, Katzka W, Jacobs JP, Charles-Schoeman C. Altered Gut Microbiome in Patients with Dermatomyositis. ACR Open Rheumatol. 2022 May 26. doi: 10.1002/acr2.11436. Online ahead of print. [PMID: 35615912]
Medel-Matus J, Lagishetty V, Santana-Gomez C, Shin D, Mowrey W, Staba RJ, Galanopoulou AS, Sankar R, *Jacobs JP, *Mazarati AM. Susceptibility to epilepsy after traumatic brain injury is associated with preexistent gut microbiome profile. Epilepsia. 2022 Jul;63(7):1835-1848. [PMID: 35366338] *Co-senior authors
Lee SM, Milillo MM, Krause-Sorio B, Siddarth P, Kilpatrick L, Narr KL, Jacobs JP, Lavretsky H. Gut Microbiome Diversity and Abundance Correlate with Gray Matter Volume (GMV) in Older Adults with Depression. Int J Environ Res Public Health. 2022 Feb 19;19(4):2405. [PMID: 35206594]
Yang J, Lagishetty V, Kurnia P, Henning SM, Ahdoot AI, Jacobs JP. Microbial and Chemical Profiles of Commercial Kombucha Products. Nutrients. 2022 Feb 5;14(3):670. [PMID: 35277029]
Andréasson K, Lee SM, Lagishetty V, Wu M, Howlett N, English J, Hesselstrand R, Clements PJ, Jacobs JP, Volkmann ER. Disease Features and Gastrointestinal Microbial Composition in Patients with Systemic Sclerosis from Two Independent Cohorts. ACR Open Rheumatol. 2022 Feb 17. [PMID: 35174673]
Yang J, Germano PM, Oh S, Wang S, Wang J, Lee R, Paige H, Yang S, Henning SM, Zhong J, Jacobs JP, Li Z. Pomegranate Extract Improves Colitis in IL-10 Knockout Mice Fed a High Fat High Sucrose Diet. Mol Nutr Food Res. 2022 Mar;66(5):e2100730. [PMID: 34932869]
Yoon LS, Jacobs JP, Hoehner J, Pereira A, Gana JC, Corvalán C, Michels KB. The association between breast density and gut microbiota composition at 2 years post menarche: A cross-sectional study of adolescents in Santiago, Chile. Front Cell Infect Microbiol. 2021 Dec 17;11:794610. [PMID: 34976871]
Zhou Y, Duan L, Zeng Y, Niu L, Pu Y, Jacobs JP, Chang C, Wang J, Khalique A, Pan K, Fang J, Jing B, Zeng D, Ni X. The Panda-Derived Lactobacillus plantarum G201683 Alleviates the Inflammatory Response in DSS-Induced Panda Microbiota-Associated Mice. Front Immunol. 2021 Dec 8;12:747045. [PMID: 34956180]
Mirzayi C, Renson A, STORMS Consortium in alphabetical order (Jacobs JP), Jones HE, Waldron L. Reporting guidelines for human microbiome research: the STORMS checklist. Nat Med. 2021 Nov;27(11):1885-1892. [PMID: 34789871]
Jacobs JP, Gupta A, Bhatt RR, Brawer J, Gao K, Tillisch K, Lagishetty V, Firth R, Gudleski GD, Ellingson BM, Labus JS, Naliboff BD, Lackner JM, Mayer EA. Cognitive behavioral therapy for irritable bowel syndrome induces bidirectional alterations in the brain-gut-microbiome axis associated with gastrointestinal symptom improvement. Microbiome. 30 November 2021
Jasinska AJ, Dong TS, Lagishetty V, Katzka W, Jacobs JP, Schmitt CA, Cramer JD, Ma D, Coetzer WG, Grobler JP, Turner TR, Freimer N, Pandrea I, Apetrei C. Shifts in microbial diversity, composition and functionality in the gut and genital microbiome during a natural SIV infection in vervet monkeys. Microbiome. 2020 Nov 6;8(1):154. [PMID: 33158452]
Volkmann ER, Hoffmann-Vold A, Chang Y, Lagishetty V, Clements PJ, Midtvedt O, Molberg O, Braun J, Jacobs JP. Longitudinal characterisation of the gastrointestinal tract microbiome in systemic sclerosis. EMJ. 2020;5(4):110-118
Hung T, Dong T, Chen Z, Elashoff D, Sinsheimer JS, Jacobs JP, Lagishetty V, Vora P, Stains J, Mayer EA, Gupta A. Understanding the heterogeneity of obesity and the relationship to the brain-gut axis. Nutrients. 2020 Nov 30;12(12):3701. [PMID: 33266058]
Osadchiy V, Mayer EA, Gao K, Labus JS, Naliboff B, Tillisch K, Chang L, Jacobs JP, Hsiao EY, Gupta A. Analysis of brain networks and fecal metabolites reveals brain-gut alterations in premenopausal females with irritable bowel syndrome. Transl Psychiatry. 2020 Nov 2;10(1):367. [PMID: 33139708]
Turkiewicz J, Bhatt RR, Wang H, Vora P, Krause B, Sauk JS, Jacobs JP, Bernstein CN, Kornelsen J, Labus JS, Gupta A, Mayer EA. Altered brain structural connectivity in patients with longstanding gut inflammation is correlated with psychological symptoms and disease duration. Neuroimage Clin. 2021 Mar 9;30:102613. [PMID: 33823388]
Lee SM , Dong TS, Krause-Sorio B, Siddarth P , Milillo MM, Lagishetty V, Datta T, Aguilar-Faustino Y, Jacobs JP, Lavretsky H. The intestinal microbiota as a predictor for antidepressant treatment outcome in geriatric depression: a prospective pilot study. Int Psychogeriatr. 2021 Mar 24;1-13. [PMID: 33757609]
Dong TS, Luu K, Lagishetty V, Sedighian F, Woo S, Dreskin BW, Katzka W, Chang C, Zhou Y, Arias-Jayo N, Yang J, Ahdoot AI, Ye J, Li Z, Pisegna JR, Jacobs JP. Gut microbiome profiles associated with steatosis severity in metabolic associated fatty liver disease. Hepatoma Res. 2021;7:37
Dreskin BW, Luu K, Dong TS, Benhammou J, Lagishetty V, Vu J, Sanford D, Durazo F, Agopian VG, Jacobs JP, Pisegna JR, Hussain SK. Specimen collection and analysis of the duodenal microbiome. J Vis Exp. 2021; 167: e61900. [PMID: 33522511]
Mazarati A, Medel-Matus J, Shin D, Jacobs JP, Sankar R. Disruption of intestinal barrier and endotoxemia after traumatic brain injury: Implications for post-traumatic epilepsy. Epilepsia. 2021 Jun;62(6):1472-1481. [PMID: 33893636]
Lenhart A, Dong T, Joshi S, Jaffe N, Choo C, Liu C, Jacobs JP, Lagishetty V, Shih W, Labus J, Gupta A, Tillisch K, Mayer EA, Chang L. Effect of exclusion diets on symptom severity and the gut microbiota in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol. 2021 May 19;S1542-3565(21)00565-6. [PMID: 34022450]
Coley EJL, Mayer EA, Osadchiy V, Chen Z, Subramanyam V, Zhang Y, Hsiao EY, Gao K, Bhatt R, Dong T, Vora P, Naliboff B, Jacobs JP, Gupta A. Early life adversity predicts brain-gut alterations associated with increased stress and mood. Neurobiol Stress. 2021 May 25;15:100348. [PMID: 34113697]
Martinez JE, Kahana DD, Ghuman S, Wilson HP, Wilson J, Kim SCJ, Lagishetty V, Jacobs JP, Sinha-Hikim AP, Friedman TC. Unhealthy lifestyle and gut dysbiosis: A better understanding of the effects of poor diet and nicotine on the intestinal microbiome. Front Endocrinol. 2021 Jun 8;12:667066. [PMID: 34168615]
Fox M, Lee SM, Wiley KS, Lagishetty V, Sandman CA, Jacobs JP, Glynn LM. Development of the infant gut microbiome predicts temperament across the first year of life. Dev Psychopathol. 2021 Jun 10;1-12. [PMID: 34108055]
Dong TS, Luu K, Lagishetty V, Sedighian F, Woo S, Dreskin BW, Katzka W, Chang C, Zhou Y, Arias-Jayo N, Yang J, Ahdoot AI, Ye J, Li Z, Pisegna JR, Jacobs JP. The intestinal microbiome predicts weight loss on a calorie-restricted diet and is associated with improved hepatic steatosis. Front Nutr. 2021 Jul 8;8:718661. [PMID: 34307440]
Shieh A, Lee SM, Lagishetty V, Gottleib C, Jacobs JP, Adams JS. Pilot trial of cholecalciferol and calcifediol in healthy vitamin D deficient adults: does it change the fecal microbiome? J Clin Endocrinol Metab. 2021 Aug 3;dgab573. [PMID: 34343292]
Jones JD, Dominguez D, Bunch J, Uribe C, Valenzuela Y, Jacobs JP. A bidirectional relationship between anxiety, depression and gastrointestinal symptoms in Parkinson’s disease. Clinical Parkinsonism & Related Disorders. 2021 Aug 10;5:100104. [PMID: 34430845]
Katzka W, Dong TS, Luu K, Lagishetty V, Sedighian F, Arias-Jayo N, Jacobs JP, Hsu HY. The ocular microbiome is altered by sampling modality and age. Transl Vis Sci Technol. 2021 Oct 4;10(12):24. [PMID: 34661621]
Chang CC, Huang ZY, Shih SH, Luo Y, Ko A, Cui Q, Sumner J, Cavallero S, Das S, Gao W, Sinsheimer J, Bui A, Jacobs JP, Pajukanta P, Wu H, Tai YC, Li Z, Hsiai TK. Electrical impedance tomography for non-invasive identification of fatty liver infiltrate in overweight individuals. Sci Rep. 2021 Oct 6;11(1):19859. [PMID: 34615918]
Mukherjee P, Chattopadhyay A, Girjalva V, Dorreh N, Lagishetty V, Jacobs JP, Clifford BL, Vallim T, Mack JJ, Navab M, Reddy ST, Fogelman AM. Oxidized phospholipids cause changes in jejunum mucus that induce dysbiosis and systemic inflammation. J Lipid Res. 2021 Nov 19;100153. [PMID: 34808192]
Dong TS, Jacobs JP, Agopian V, Pisegna JR, Ayoub W, Durazo F, Enayati P, Sundaram V, Benhammou JN, Noureddin M, Choi G, Lagishetty V, Fiehn O, Goodman MT, Elashoff D, Hussain SK. Duodenal microbiome and serum metabolites predict hepatocellular carcinoma in a multicenter cohort of patients with cirrhosis. Dig Dis Sci. 2021 Nov 20. [PMID: 34799768]
Dreskin BW, Luu K, Dong TS, Benhammou J, Lagishetty V, Vu J, Sanford D, Durazo F, Agopian VG, Jacobs JP, Pisegna JR, Hussain SK. Specimen collection and analysis of the duodenal microbiome. J Vis Exp. 2021; 167: e61900. [PMID: 33522511]
Martinez JE, Kahana DD, Ghuman S, Wilson HP, Wilson J, Kim SCJ, Lagishetty V, Jacobs JP, Sinha-Hikim AP, Friedman TC. Unhealthy lifestyle and gut dysbiosis: A better understanding of the effects of poor diet and nicotine on the intestinal microbiome. Front Endocrinol. 2021 Jun 8;12:667066. [PMID: 34168615]
Jasinska AJ, Dong TS, Lagishetty V, Katzka W, Jacobs JP, Schmitt CA, Cramer JD, Ma D, Coetzer WG, Grobler JP, Turner TR, Freimer N, Pandrea I, Apetrei C. Shifts in microbial diversity, composition and functionality in the gut and genital microbiome during a natural SIV infection in vervet monkeys. Microbiome, in press
Bergstrom K, Shan X, Casero D, Batushansky A, Lagishetty V, Jacobs JP, Hoover C, Kondo Y, Shao B, Gao L, Zandberg W, Noyovitz B, McDaniel JM, Gibson DL, Pakpour S, Kazemian N, McGee S, Houchen CW, Rao CV, Griffin TM, Sonnenburg JL, McEver RP, Braun J, Xia L. Proximal colon-derived O-glycosylated mucus encapsulates and modulates the microbiota. Science. 2020 Oct 23;370(6515):467-472. [PMID: 33093110]
Dong TS, Luu K, Lagishetty V, Sedighian F, Woo S, Dreskin BW, Katzka W, Chang C, Zhou Y, Arias-Jayo N, Yang J, Ahdoot A, Li Z, Pisegna JR, Jacobs JP. A High Protein Calorie Restriction Diet Alters the Gut Microbiome in Obesity. Nutrients. 2020 Oct 21;12(10):3221. [PMID: 33096810]
Dong TS, Gupta A, Jacobs JP, Lagishetty V, Gallagher E, Bhatt RR, Vora P, Osadchiy V, Stains J, Balioukova A, Chen Y, Dutson E, Mayer EA, Sanmiguel C. Improvement in Uncontrolled Eating Behavior after Laparoscopic Sleeve Gastrectomy Is Associated with Alterations in the Brain–Gut–Microbiome Axis in Obese Women. Nutrients. 2020 Sep 24;12(10):2924. [PMID: 32987837]
Dong TS, Mayer EA, Osadchiy V, Chang C, Katzka W, Lagishetty V, Gonzalez K, Kalani A, Stains J, Jacobs JP, Longo VD, Gupta A. A Distinct Brain-Gut Microbiome Profile Exists for Obese Females with Food Addiction. Obesity (Silver Spring). 2020 Aug;28(8):1477-1486. [PMID: 32935533]
Hussain SK, Dong TS, Agopian V, Pisegna JR, Durazo FA, Enayati P, Sundaram V, Benhammou JN, Noureddin M, Choi G, Ayoub WS, Lagishetty V, Elashoff D, Goodman MT, Jacobs JP. Dietary Protein, Fiber and Coffee Are Associated with Small Intestine Microbiome Composition and Diversity in Patients with Liver Cirrhosis. Nutrients. 2020 May 13;12(5):1395. [PMID: 32414035]
Jones JD, Rahmani E, Garcia E, Jacobs JP. Gastrointestinal Symptoms Are Predictive of Trajectories of Cognitive Functioning in De Novo Parkinson's Disease. Parkinsonism Relat Disord. 2020; 72:7-12. [PMID: 32058266]
Dong TS, Katzka W, Lagishetty V, Luu K, Hauer M, Pisegna J, Jacobs JP. A Microbial Signature Identifies Advanced Fibrosis in Patients with Chronic Liver Disease Mainly Due to NAFLD. Sci Rep. 2020 Feb 17;10(1):2771. [PMID: 32066758]
Basak SK, Bera A, Yoon AJ, Morselli M, Jeong C, Tosevska A, Dong TS, Eklund M, Russ E, Nasser H, Lagishetty V, Guo R, Sajed D, Mudgal S, Mehta P, Avila L, Srivastava M, Faull K, Jacobs J, Pellegrini M, Shin DS, Srivatsan ES, Wang MB. A randomized, phase 1, placebo-controlled trial of APG-157 in oral cancer demonstrates systemic absorption and an inhibitory effect on cytokines and tumor-associated microbes. Cancer. 2020 Feb 5. doi: 10.1002/cncr.32644. [PMID: 32022261]
Dong TS, Chang HH, Hauer M, Lagishetty V, Katzka, Rozengurt E, Jacobs JP, Eibl G. Metformin Alters the Duodenal Microbiome and Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity. Am J Physiol Gastrointest Liver Physiol. 2019 Dec 1:317(6):G763-G772.
Bajaj JS, Sharma A, Dudeja PK, Iqbal Z, Singh AB, Wilson KT, Taché Y, Pisegna J, Greenwood-Van Meerveld B, Sartor RB, Hecht G, Zhou H, Hylemon P, Im HJ, Jacobs J, Skupsky J, Sun J, Benhammou J, Ince MN, Coburn LA, Brenner L, Safdar N, Gillevet PM. Targeting Gut Microbiome Interactions in Service-Related Gastrointestinal and Liver Diseases of Veterans. Gastroenterology. 2019 Nov;157(5):1180-1183.e1. [PMID: 31404532]
Hakimian JK, Dong TS, Barahona JA, Lagishetty V, Tiwari S, Azani D, Barrera M, Lee S, Severino AL, Mittal N, Cahill CM, Jacobs JP, Walwyn WM. Dietary Supplementation with Omega-3 Polyunsaturated Fatty Acids Reduces Opioid-Seeking Behaviors and Alters the Gut Microbiome. Nutrients. 2019 Aug 14;11(8). pii: E1900. [PMID: 31416242]
Dong TS, Jacobs JP, Hussain SK. Microbial Profiles of Cirrhosis in the Human Small Intestine. Curr Gastroenterol Rep. 2019 Aug 23;21(10):50.PMID: 31444636]
Jacobs JP, Mayer EA. Psychobiotics: Shaping the Mind With Gut Bacteria. Am J Gastroenterol. 2019 Jul; 114(7):1034-1035. [PMID: 31268916]
Dong TS, Jacobs JP. Nonalcoholic fatty liver disease and the gut microbiome: Are bacteria responsible for fatty liver? Exp Biol Med (Maywood). 2019 Apr; 244(6):408-418. [PMID: 30871368]
Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh N, Braun J, Jacobs JP, Clemente JC, Grinspan A, Sands BE, Colombel JF, Dubinsky MC, Faith JJ. Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice. Immunity. 2019 Jan 15;50(1):212-224.e4 [PMID: 30650377]
Osadchiy V, Labus JS, Gupta A, Jacobs J, Ashe-McNalley C, Hsiao EY, Mayer EA. Correlation of tryptophan metabolites with connectivity of extended central reward network in healthy subjects. PLoS One. 2018 Aug 6;13(8):e0201772. [PMID: 30080865]
*Jacob N, *Jacobs JP, Kumagai K, Ha CWY, Kanazawa Y, Lagishetty V, Altmayer K, Hamill AM, Von Arx A, Sartor RB, Devkota S, Braun J, Michelsen KS, Targan SR, Shih DQ. Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome. Mucosal Immunol. 2018 Jul 9. doi: 10.1038/s41385-018-0055-y. [PMID: 29988118] *Co-first authors
Jacobs JP, Dong TS, Agopian V, Lagishetty V, Sundaram V, Noureddin M, Ayoub WS, Durazo F, Benhammou J, Enayati P, Elashoff D, Goodman MT, Pisegna J, Hussain S. Microbiome and bile acid profiles in duodenal aspirates from patients with liver cirrhosis: The Microbiome, Microbial Markers and Liver Disease Study. Hepatol Res. 2018 Dec;48(13):1108-1117. doi: 10.1111/hepr.13207. Epub 2018 Jul 30.
Wang J, Ghali S, Xu C, Mussatto CC, Ortiz C, Lee EC, Tran DH, Jacobs JP, Lagishetty V, Faull KF, Moller T, Rossetti M, Chen X, Koon HW. Ceragenin CSA13 Reduces Clostridium difficile Infection in Mice by Modulating the Intestinal Microbiome and Metabolites. Gastroenterology. 2018 Jan 19. pii: S0016-5085(18)30067-2. [PMID: 29360463]
Minalyan A, Gabrielyan L, Scott D, Jacobs J, Pisegna JR. The Gastric and Intestinal Microbiome: Role of Proton Pump Inhibitors. Curr Gastroenterol Rep. 2017 Aug; 19(8):42. [PMID: 28733944]
Xu C, Ghali S, Wang J, Shih DQ, Ortiz C, Mussatto CC, Lee EC, Tran DH, Jacobs JP, Lagishetty V, Fleshner P, Robbins L, Vu M, Hing TC, McGovern DPB, Koon HW. CSA13 inhibits colitis-associated intestinal fibrosis via a formyl peptide receptor like-1 mediated HMG-CoA reductase pathway. Scientific Reports. 2017;7(1):16351. [PMID: 29180648]
*Wang L, *Jacobs JP, Lagishetty V, Yuan PQ, Wu SV, Million M, Reeve JR Jr, Pisegna JR, Taché Y. High-protein diet improves sensitivity to cholecystokinin and shifts the cecal microbiome without altering brain inflammation in diet-induced obesity in rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 2017; 313(4):R473-R486. [PMID: 28724546] *Co-first authors
Volkmann ER, Hoffmann-Vold AM, Chang YL, Jacobs JP, Tillisch K, Mayer EA, Clements PJ, Hov JR, Kummen M, Midtvedt Ø, Lagishetty V, Chang L, Labus JS, Molberg Ø, Braun J. Systemic sclerosis is associated with specific alterations in gastrointestinal microbiota in two independent cohorts. BMJ Open Gastroenterology. 2017; 4(1):e000134. [PMID: 28761687]
Li R, Yang J, Saffari A, Jacobs J, Baek KI, Hough G, Larauche MH, Ma J, Jen N, Moussaoui N, Zhou B, Kang H, Reddy S, Henning SM, Campen MJ, Pisegna J, Li Z, Fogelman AM, Sioutas C, Navab M, Hsiai TK. Ambient Ultrafine Particle Ingestion Alters Gut Microbiota in Association with Increased Atherogenic Lipid Metabolites. Scientific Reports. 2017; 7:42906. [PMID:28211537]
Labus JS, Hollister EB, Jacobs J, Kirbach K, Oezguen N, Gupta A, Acosta J, Luna RA, Aagaard K, Versalovic J, Savidge T, Hsiao E, Tillisch K, Mayer EA. Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome. Microbiome. 2017; 5(1):49. [PMCID:PMC5410709]
Sanmiguel CP, Jacobs J, Gupta A, Ju T, Stains J, Coveleskie K, Lagishetty V, Balioukova A, Chen Y, Dutson E, Mayer E, Labus JS. Surgically induced changes in gut microbiome and hedonic eating as related to weight loss: Preliminary findings in obese women undergoing bariatric surgery. Psychosom Med. 2017 May 30. [Epub ahead of print]
Jacobs JP, Goudarzi M, Singh N, Tong M, McHardy IH, Ruegger P, Asadourian M, Moon B, Ayson A, Borneman J, McGovern DPB, Fornace AJ, Braun J, Dubinsky M. A disease-associated microbial and metabolomics state in relatives of pediatric inflammatory bowel disease patients. Cellular and Molecular Gastroenterology and Hepatology. 2016 Jul; 2(6):750-66. [PMID: 28174747]
Jacobs JP, Lin L, Goudarzi M, Ruegger P, McGovern DPB, Fornace AJ, Borneman J, Xia L, Braun J. Microbial, metabolomic, and immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency. Gut Microbes. 2017 Jan; 8(1):1-16. [PMID: 27874308]
*Moussaoui N, *Jacobs JP, Larauche M, Biraud M, Million M, Mayer E, Taché Y. Chronic Early-life Stress in Rat Pups Alters Basal Corticosterone, Intestinal Permeability, and Fecal Microbiota at Weaning: Influence of Sex. Journal of Neurogastroenterology and Motility. 2017; 23(1):135-143. [PMCID:PMC5216644] *Co-first authors
Li D, Achkar JP, Haritunians T, Jacobs JP, Hui KY, D'Amato M, Brand S, Radford-Smith G, Halfvarson J, Niess JH, Kugathasan S, Büning C, Schumm LP, Klei L, Ananthakrishnan A, Aumais G, Baidoo L, Dubinsky M, Fiocchi C, Glas J, Milgrom R, Proctor DD, Regueiro M, Simms LA, Stempak JM, Targan SR, Törkvist L, Sharma Y, Devlin B, Borneman J, Hakonarson H, Xavier RJ, Daly M, Brant SR, Rioux JD, Silverberg MS, Cho JH, Braun J, McGovern DP, Duerr RH. A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition. Gastroenterology. 2016; 151(4):724-32. [PMID: 27492617]
Goudarzi M, Mak TD, Jacobs JP, Moon BH, Strawn SJ, Braun J, Brenner DJ, Fornace AJ Jr, Li HH. An Integrated Multi-Omic Approach to Assess Radiation Injury on the Host-Microbiome Axis. Radiation Research. 2016; 186(3):219-34. [PMID: 27512828]
Volkmann ER, Chang YL, Barroso N, Furst DE, Clements PJ, Gorn AH, Roth BE, Conklin JL, Getzug T, Borneman J, McGovern DP, Tong M, Jacobs JP, Braun J. Association of Systemic Sclerosis With a Unique Colonic Microbial Consortium. Arthritis & Rheumatology. 2016; 68(6):1483-92. [PMID: 26749064]
Jacobs J, Braun J. Host genes and their effect on the intestinal microbiome garden. Genome Med. 2014 Dec 17; 6(12):119. [PMID: 25593597]
Tong M, Jacobs JP, McHardy IH. Sampling of intestinal microbiota and targeted amplification of bacterial 16S rRNA genes for microbial ecologic analysis. Curr Protoc Immunol. 2014 Nov 3;107:7.41.1-7.41.11. [PMID: 25367129]
Jacobs JP, Braun J. Immune and genetic gardening of the intestinal microbiome. FEBS Letters. 2014 Nov; 588(22):4102-11. [PMID: 24613921]
McHardy I, Li X, Tong M, Ruegger P, Jacobs J, Borneman J, Anton P, Braun J. HIV infection is associated with compositional and functional shifts in the rectal mucosal microbiota. Microbiome. 2013 Oct; 1(1):26. [PMID: 24451087]