Chronic Liver Disease and Hepatocellular Carcinoma
Although overall cancer incidence and mortality have steadily declined in the United States over the past 15 years, liver cancer incidence and mortality have been on the rise. Ethnic minority groups experience a disproportionate burden of chronic liver disease and liver cancer.
The May Laboratory focuses on developing clinical pathways to identify patients who are at risk for chronic liver disease and liver cancer. Radiographic and clinical lab information available in electronic medical records is used along with population risk data based on race, gender and age in an automated process to predict the likelihood of liver disease and liver disease progression.
Our liver disease research leverages population health, health disparities, clinical medicine, machine learning, and metabolomics to enhance risk prediction, provide insights regarding liver cancer oncogenesis and inform a precision-health approach to managing at-risk patients in the clinical setting.

Collaborators
- Yvonne Flores, PhD, Professor, Health Equity
- Roshan Bastani, PhD, Professor, Health Policy and Management
- Beth Glenn, PhD, Associate Professor, Health Policy and Management
- Arpan A. Patel, MD, PhD, Assistant Clinical Professor of Medicine
Grants
- David Geffen School of Medicine Impact Grant; “Liver Cancer Prevention and Control - Understanding and Addressing Disparities” (Co-I)
Publications -
- Flores YN, Datta GD, Yang L, Corona E, Devineni D, Glenn BA, Bastani R, May FP. . Cancer Epidemiol Biomarkers Prev. 2021 Jun;30(6):1193-1199. doi: 10.1158/1055-9965.EPI-20-1088. Epub 2021 Mar 18. PMID: 33737301; PMCID: PMC8172467
- Kardashian A, Patel AA, Aby ES, Cusumano VT, Soroudi C, Winters AC, Wu E, Beah P, Delshad S, Kim N, Yang L, May FP. . Hepatol Commun. 2020 Sep 9;4(12):1802-1811. doi: 10.1002/hep4.1594. PMID: 33305151; PMCID: PMC7706302
- Bakr O, Gelberg L, Seragaki S, Youn S, Kawamoto J, Hoppe M, Altman L, Kopelson K, May FP, Cowan B, Bhattacharya D. . Hepatology. 2019 Apr 4;. doi: 10.1002/hep.30643. [Epub ahead of print] PubMed PMID: 30945758
- May FP, Rolston VS, Tapper EB, Lakshmanan A, Saab S, Sundaram V. . BMC Gastroenterol. 2016 Oct 10;16(1):129. PMID:27724882
- Patel AA, Walling AM, May FP, Saab S, Wenger N. . Clin Gastroenterol Hepatol. 2017 Feb 4. [Epub ahead of print]. PMID: 28179192
- Sundaram V, May FP, Manne V, Saab S. . Clin Gastroenterol Hepatol. 2014 Oct;12(10):1745-52. PMID: 24681081
- Benhammou JN, Dong TS, May FP,Kawamoto J, Dixit R, Jackson S, Dixit V, Bhattacharya D, Han SB, Pisegna JR. . Pharmacol Res Perspect. 2018 Feb 22;6(2):e00379. doi: 10.1002/prp2.379. eCollection 2018 Apr. PMID: 29484189
- Dong TS, Aby ES, Benhammou JN, Kawamoto J, Han SH, May FP,Pisegna JR. . World J Hepatol. 2018 Sept 27; 10(9):612-621. doi: 10.4254/wjh.v10.i9.612. PMID: 30310539