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Breadcrumb
  1. Home
  2. Departments
  3. Neurosurgery
  4. Research
  5. Research Faculty
Neurosurgery

Janel Le Belle, PhD

Sub-navigation

Research Faculty
  • David A. Hovda, PhD
  • Jeffrey Chiang, PhD
  • Ashley Feinsinger, PhD
  • Fernando Gomez-Pinilla, PhD
  • Tiffany Greco, PhD
  • Neil G. Harris, PhD
  • Janel Le Belle, PhD
  • Mayumi Prins, PhD
  • Robert M Prins, PhD
Research Faculty
  • David A. Hovda, PhD
  • Jeffrey Chiang, PhD
  • Ashley Feinsinger, PhD
  • Fernando Gomez-Pinilla, PhD
  • Tiffany Greco, PhD
  • Neil G. Harris, PhD
  • Janel Le Belle, PhD
  • Mayumi Prins, PhD
  • Robert M Prins, PhD
Dr. Le Belle

Janel Le Belle, PhD
Associate Adjunct Professor

Academic Affiliation
David Geffen School of Medicine at UCLA
Department of Neurosurgery
PO Box 956901
Los Angeles, CA 90095-6901

Contact: (310) 983-3486
jlebelle@mednet.ucla.eduLink sends email

Education

  • Ph.D., Biochemistry, University College London, 1995-1999
  • B.A, Philosophy, Neuroscience, University of Florida, 1990-1995

Research Area

Dr. Le Belle is an adjunct associate professor faculty member with expertise in stem cell biology, exogenous and endogenous cellular brain repair following injury, fatty acid metabolism, signaling, and regulation of neural stem cells in the aging brain and in glioma stem cells, and the effects of neuroinflammation on brain development, neural stem cell function, and neurogenesis. She has worked for several years on the etiology of brain overgrowth, abnormal sensory processing, and abnormal behaviors in neurodevelopmental mouse models. Her lab is currently funded to research the shared brain functional circuitry, physiological (heart) responses, and cognitive function in mice and humans with sensory over-responsivity and post-concussion sensory hyper-sensitivity to identify if there are convergent mechanisms between disorders and across species. The lab is also pursuing research on the effects of neuro-inflammatory risk factors like Diabetes and prior Covid infections on sensory, motor, and cognitive outcomes following repeat concussion injury. Dr. Le Belle teaches Neuroanatomy, Neurophilosophy, and Stem Cell Biology classes on campus. She has both a research and academic interest in furthering our understanding of human consciousness and conscious sensory experience and interoception.

Links

Department of Neurosurgery

Publications (recent articles)

PublicationYear

Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant mannerLink is external(Link is external)

JE Le Belle, NM Orozco, AA Paucar, JP Saxe, J Mottahedeh, AD Pyle, ...
Cell stem cell 8 (1), 59-71
2011

PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entryLink is external(Link is external)

M Groszer, R Erickson, DD Scripture-Adams, JD Dougherty, J Le Belle, ...
Proceedings of the National Academy of Sciences 103 (1), 111-116
2006

Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesisLink is external(Link is external)

C Gregorian, J Nakashima, J Le Belle, J Ohab, R Kim, A Liu, KB Smith, ...
Journal of Neuroscience 29 (6), 1874-1886
2009

Maternal inflammation contributes to brain overgrowth and autism-associated behaviors through altered redox signaling in stem and progenitor cellsLink is external(Link is external)

JE Le Belle, J Sperry, A Ngo, Y Ghochani, DR Laks, M López-Aranda, ...
Stem cell reports 3 (5), 725-734
2014

Stem cells for neurodegenerative disorders: where can we go from here?Link is external(Link is external)

JE Le Belle, CN Svendsen
BioDrugs 16, 389-401
2002

Inosine promotes recovery of skilled motor function in a model of focal brain injuryLink is external(Link is external)

JM Smith, P Lunga, D Story, N Harris, J Le Belle, MF James, JD Pickard, ...
Brain 130 (4), 915-925
2007

Improving the survival of human CNS precursor‐derived neurons after transplantationLink is external(Link is external)

JE Le Belle, MA Caldwell, CN Svendsen
Journal of neuroscience research 76 (2), 174-183
2004

Glioblastoma utilizes fatty acids and ketone bodies for growth allowing progression during ketogenic diet therapyLink is external(Link is external)

J Sperry, MC Condro, L Guo, D Braas, N Vanderveer-Harris, KKO Kim, ...
Iscience 23 (9)
2020

Traumatic brain injury reveals novel cell lineage relationships within the subventricular zoneLink is external(Link is external)

GM Thomsen, JE Le Belle, JA Harnisch, WS Mc Donald, DA Hovda, ...
Stem cell research 13 (1), 48-60
2014

Docosahexaenoic Acid has stem cell-specific effects in the SVZ and restores olfactory neurogenesis and function in the aging brainLink is external(Link is external)

JE Le Belle, J Sperry, K Ludwig, NG Harris, MA Caldwell, HI Kornblum
bioRxiv, 2020.02. 10.942870
2020

Metabolism of fatty acids and ketone bodies for glioblastoma growth: Implications for Ketogenic Diet TherapyLink is external(Link is external)

J Sperry, JE Le Belle, MC Condro, L Guo, D Braas, N Vanderveer-Harris, ...
bioRxiv, 659474
2019

Interactive Regulation of Neuronal Development by Hippocampal Stem Cell Niche PopulationsLink is external(Link is external)

JE Le Belle, HI Kornblum
Neuron 101 (1), 1-2
2019

RBIO-06. NADPH oxidase (NOX) promotes radiation resistance through oxidation of pten in glioblastomaLink is external(Link is external)

K Ludwig, J Le Belle, J Sperry, E Vlashi, F Pajonk, H Kornblum
Neuro-Oncology 19 (Suppl 6), vi218
2017

A comparison of cell and tissue extraction techniques using high-resolution 1H-NMR spectroscopy (vol 15, pg 37, 2002)Link is external(Link is external)

JE Le Belle, NG Harris, SR Williams, KK Bhakoo
NMR IN BIOMEDICINE 29 (4), 527-527
2016

A comparison of cell and tissue extraction techniques using high‐resolution 1H‐NMR spectroscopyLink is external(Link is external)

JE Le Belle, NG Harris, SR Williams, KK Bhakoo
NMR in Biomedicine 29 (4), 527-527
2016

Nicotinamide Adenine Dinucleotide Phosphate Oxidase Promotes Glioblastoma Radiation Resistance in a Phosphate and Tensin Homolog-Dependent MannerLink is external(Link is external)

K Ludwig, JE Le Belle, SD Muthukrishnan, J Sperry, M Condro, E Vlashi, ...
Antioxidants & Redox Signaling 39 (13-15), 890-903
2023

NADPH oxidase promotes glioblastoma radiation resistance in a PTEN-dependent mannerLink is external(Link is external)

K Ludwig, JE Le Belle, SD Muthukrishnan, J Sperry, M Condro, E Vlashi, ...
bioRxiv, 2022.06. 16.496502
2022

NON-PROLIFERATIVE EXPANSION OF SVZ ASTROCYTE AND ACTIVATED STEM CELL POPULATIONS OCCURS AS EGFR (+) CELLS BECOME LESS PROLIFERATIVE AFTER BRAIN INJURYLink is external(Link is external)

G Thomsen, J Le Belle, J Harnisch, D Hovda, H Kornblum, N Harris
JOURNAL OF NEUROTRAUMA 28 (6), A80-A80
2011

ENDOGENOUS SVZ NEURAL STEM AND PROGENITOR CELLS ARE STIMULATED TO DIVIDE AND GENERATE NEW CORTICAL CELLS FOLLOWING TRAUMATIC BRAIN INJURYLink is external(Link is external)

G Miller, J Le Belle, D Hovda, H Kornblum, N Harris
JOURNAL OF NEUROTRAUMA 26 (8), A6-A6
2009

Effect of traumatic brain injury on the normally quiescent population of neural stem cells in the adult mouse SVZLink is external(Link is external)

G Miller, J Le Belle, D Hovda, H Kornblum, N Harris
JOURNAL OF NEUROTRAUMA 25 (7), 921-921
2008
View my publications on PubMedLink is external(Link is external)


 

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