Contact Information Mailing Address: Peter Tontonoz, MD, PhD
UCLA Path & Lab Med Box 951662, 6770 MRL Los Angeles, CA 90095 310-206-4546ptontonoz@mednet.ucla.eduLink sends email (Link opens in new window)
Academic Title Professor, Pathology & Laboratory Medicine
Bio
Peter Tontonoz is the Frances and Albert Piansky Endowed Chair and Distinguished Professor of Pathology and Laboratory Medicine and of Biological Chemistry. Dr. Tontonoz received his B.A. from Wesleyan University and his M.D. and Ph.D. from Harvard Medical School. Dr. Tontonoz’s laboratory endeavors to understand regulatory pathways that govern cholesterol, fatty acid and phospholipid metabolism. His work has helped to reveal fundamental mechanisms by which animals maintain cellular and whole-body lipid homeostasis. His group has elucidated pathways for the control of lipid uptake, transport and efflux, and has shown how these pathways impact the function of immune cells and metabolic tissues in both physiology and disease. Dr. Tontonoz is a member of the National Academy of Sciences, the National Academy of Medicine, the American Society for Clinical Investigation, and the Association of American Physicians. He has received a number of national awards, including the Stanley J. Korsmeyer Award from the American Society of Clinical Investigation, the Richard Weitzman Award and the Gerald D. Aurbach Award from the Endocrine Society, and the Jeffrey Hoeg Award from the American Heart Association. Dr. Tontonoz serves on many editorial boards, including those of eLife, Genes & Development, Diabetes, and the Journal of Clinical Investigation.
Publications
Kennelly JP, Tontonoz P. Cholesterol Transport to the Endoplasmic Reticulum.Link is external (Link is external) (Link opens in new window) . Cold Spring Harbor perspectives in biology, 2023. Yao T, Yan H, Zhu X, Zhang Q, Kong X, Guo S, Feng Y, Wang H, Hua Y, Zhang J, Mittelman SD, Tontonoz P, Zhou Z, Liu T, Kong X. Erratum. Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome. Diabetes 2022;71:2256-2271.Link is external (Link is external) (Link opens in new window) . Diabetes, 2023. Xiao X, Kennelly JP, Ferrari A, Clifford BL, Whang E, Gao Y, Qian K, Sandhu J, Jarrett KE, Brearley-Sholto MC, Nguyen A, Nagari RT, Lee MS, Zhang S, Weston TA, Young SG, Bensinger SJ, Villanueva CJ, de Aguiar Vallim TQ, Tontonoz P. Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis.Link is external (Link is external) (Link opens in new window) . Nature metabolism, 2023. Bideyan L, López Rodríguez M, Priest C, Kennelly JP, Gao Y, Ferrari A, Rajbhandari P, Feng AC, Tevosian SG, Smale ST, Tontonoz P. Hepatic GATA4 regulates cholesterol and triglyceride homeostasis in collaboration with LXRs.Link is external (Link is external) (Link opens in new window) . Genes & development, 2022. Qian K, Tol MJ, Wu J, Uchiyama LF, Xiao X, Cui L, Bedard AH, Weston TA, Rajendran PS, Vergnes L, Shimanaka Y, Yin Y, Jami-Alahmadi Y, Cohn W, Bajar BT, Lin CH, Jin B, DeNardo LA, Black DL, Whitelegge JP, Wohlschlegel JA, Reue K, Shivkumar K, Chen FJ, Young SG, Li P, Tontonoz P. CLSTN3� enforces adipocyte multilocularity to facilitate lipid utilization.Link is external (Link is external) (Link opens in new window) . Nature, 2022. Yao T, Yan H, Zhu X, Zhang Q, Kong X, Guo S, Feng Y, Wang H, Hua Y, Zhang J, Mittelman SD, Tontonoz P, Zhou Z, Liu T, Kong X. Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome.Link is external (Link is external) (Link opens in new window) . Diabetes, 2022. Abrego J, Sanford-Crane H, Oon C, Xiao X, Betts CB, Sun D, Nagarajan S, Diaz L, Sandborg H, Bhattacharyya S, Xia Z, Coussens LM, Tontonoz P, Sherman MH. A Cancer Cell-Intrinsic GOT2-PPARδ Axis Suppresses Antitumor Immunity.Link is external (Link is external) (Link opens in new window) . Cancer discovery, 2022. Chen K, Song W, Russell R, Ferrari A, Darwish T, Tontonoz P, Young SG, Jiang H. NanoSIMS imaging of lipid absorption by intestinal enterocytes.Link is external (Link is external) (Link opens in new window) . Journal of lipid research, 2022. Palladino END, Bernas T, Green CD, Weigel C, Singh SK, Senkal CE, Martello A, Kennelly JP, Bieberich E, Tontonoz P, Ford DA, Milstien S, Eden ER, Spiegel S. Sphingosine kinases regulate ER contacts with late endocytic organelles and cholesterol trafficking.Link is external (Link is external) (Link opens in new window) . Proceedings of the National Academy of Sciences of the United States of America, 2022. Shi H, Guo J, Yu Q, Hou X, Liu L, Gao M, Wei L, Zhang L, Huang W, Wang Y, Liu G, Tontonoz P, Xian X. CRISPR/Cas9 based blockade of IL-10 signaling impairs lipid and tissue homeostasis to accelerate atherosclerosis.Link is external (Link is external) (Link opens in new window) . Frontiers in immunology, 2022. Priest C, Nagari RT, Bideyan L, Lee SD, Nguyen A, Xiao X, Tontonoz P. Brap regulates liver morphology and hepatocyte turnover via modulation of the Hippo pathway.Link is external (Link is external) (Link opens in new window) . Proceedings of the National Academy of Sciences of the United States of America, 2022. Song W, Beigneux AP, Winther AL, Kristensen KK, Grønnemose AL, Yang Y, Tu Y, Munguia P, Morales J, Jung H, de Jong PJ, Jung CJ, Miyashita K, Kimura T, Nakajima K, Murakami M, Birrane G, Jiang H, Tontonoz P, Ploug M, Fong LG, Young SG. Electrostatic sheathing of lipoprotein lipase is essential for its movement across capillary endothelial cells.Link is external (Link is external) (Link opens in new window) . The Journal of clinical investigation, 2022. Bideyan L, Fan W, Kaczor-Urbanowicz KE, Priest C, Casero D, Tontonoz P. Integrative analysis reveals multiple modes of LXR transcriptional regulation in liver.Link is external (Link is external) (Link opens in new window) . Proceedings of the National Academy of Sciences of the United States of America, 2022. Guo F, Seldin M, P?terfy M, Charugundla S, Zhou Z, Lee SD, Mouton A, Rajbhandari P, Zhang W, Pellegrini M, Tontonoz P, Lusis AJ, Shih DM. NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice.Link is external (Link is external) (Link opens in new window) . Scientific reports, 2021. Bideyan L, Nagari R, Tontonoz P. Hepatic transcriptional responses to fasting and feeding.Link is external (Link is external) (Link opens in new window) . Genes & development, 2021. Ferrara PJ, Rong X, Maschek JA, Verkerke AR, Siripoksup P, Song H, Green TD, Krishnan KC, Johnson JM, Turk J, Houmard JA, Lusis AJ, Drummond MJ, McClung JM, Cox JE, Shaikh SR, Tontonoz P, Holland WL, Funai K. Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle.Link is external (Link is external) (Link opens in new window) . The Journal of clinical investigation, 2021. Xiao X, Kim Y, Romartinez-Alonso B, Sirvydis K, Ory DS, Schwabe JWR, Jung ME, Tontonoz P. Selective Aster inhibitors distinguish vesicular and nonvesicular sterol transport mechanisms.Link is external (Link is external) (Link opens in new window) . Proceedings of the National Academy of Sciences of the United States of America, 2021. Ferrari A, He C, Kennelly JP, Sandhu J, Xiao X, Chi X, Jiang H, Young SG, Tontonoz P. Aster Proteins Regulate the Accessible Cholesterol Pool in the Plasma Membrane.Link is external (Link is external) (Link opens in new window) . Molecular and cellular biology, 2020. Zhou Z, Moore TM, Drew BG, Ribas V, Wanagat J, Civelek M, Segawa M, Wolf DM, Norheim F, Seldin MM, Strumwasser AR, Whitney KA, Lester E, Reddish BR, Vergnes L, Reue K, Rajbhandari P, Tontonoz P, Lee J, Mahata SK, Hewitt SC, Shirihai O, Gastonbury C, Small KS, Laakso M, Jensen J, Lee S, Drevon CA, Korach KS, Lusis AJ, Hevener AL. Estrogen receptor a controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling.Link is external (Link is external) (Link opens in new window) . Science translational medicine, 2020. Zhou QD, Chi X, Lee MS, Hsieh WY, Mkrtchyan JJ, Feng AC, He C, York AG, Bui VL, Kronenberger EB, Ferrari A, Xiao X, Daly AE, Tarling EJ, Damoiseaux R, Scumpia PO, Smale ST, Williams KJ, Tontonoz P, Bensinger SJ. Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins.Link is external (Link is external) (Link opens in new window) . Nature immunology, 2020. Salerno AG, van Solingen C, Scotti E, Wanschel ACBA, Afonso MS, Oldebeken SR, Spiro W, Tontonoz P, Rayner KJ, Moore KJ. LDL Receptor Pathway Regulation by miR-224 and miR-520d.Link is external (Link is external) (Link opens in new window) . Frontiers in cardiovascular medicine, 2020. Ichu TA, Reed A, Ogasawara D, Ulanovskaya O, Roberts A, Aguirre CA, Bar-Peled L, Gao J, Germain J, Barbas S, Masuda K, Conti B, Tontonoz P, Cravatt BF. ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease.Link is external (Link is external) (Link opens in new window) . Biochemistry, 2020. He C, Jiang H, Song W, Riezman H, Tontonoz P, Weston TA, Guagliardo P, Kim PH, Jung R, Heizer P, Fong LG, Young SG. Cultured macrophages transfer surplus cholesterol into adjacent cells in the absence of serum or high-density lipoproteins.Link is external (Link is external) (Link opens in new window) . Proceedings of the National Academy of Sciences of the United States of America, 2020. Wang X, Cai B, Yang X, Sonubi OO, Zheng Z, Ramakrishnan R, Shi H, Valenti L, Pajvani UB, Sandhu J, Infante RE, Radhakrishnan A, Covey DF, Guan KL, Buck J, Levin LR, Tontonoz P, Schwabe RF, Tabas I. Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis.Link is external (Link is external) (Link opens in new window) . Cell metabolism, 2020. Gao J, Littman R, Diamante G, Xiao X, Ahn IS, Yang X, Cole TA, Tontonoz P. Therapeutic IDOL Reduction Ameliorates Amyloidosis and Improves Cognitive Function in APP/PS1 Mice.Link is external (Link is external) (Link opens in new window) . Molecular and cellular biology, 2020. Choudhary M, Ismail EN, Yao PL, Tayyari F, Radu RA, Nusinowitz S, Boulton ME, Apte RS, Ruberti JW, Handa JT, Tontonoz P, Malek G. LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target.Link is external (Link is external) (Link opens in new window) . JCI insight, 2020. Priest C, Tontonoz P. Inter-organ cross-talk in metabolic syndrome.Link is external (Link is external) (Link opens in new window) . Nature metabolism, 2019. Lee SD, Priest C, Bjursell M, Gao J, Arneson DV, Ahn IS, Diamante G, van Veen JE, Massa MG, Calkin AC, Kim J, Anders?n H, Rajbhandari P, Porritt M, Carreras A, Ahnmark A, Seeliger F, Maxvall I, Eliasson P, Althage M, ?kerblad P, Lind?n D, Cole TA, Lee R, Boyd H, Bohlooly-Y M, Correa SM, Yang X, Tontonoz P, Hong C. IDOL regulates systemic energy balance through control of neuronal VLDLR expression.Link is external (Link is external) (Link opens in new window) . Nature metabolism, 2019. Rajbhandari P, Arneson D, Hart SK, Ahn IS, Diamante G, Santos LC, Zaghari N, Feng AC, Thomas BJ, Vergnes L, Lee SD, Rajbhandari AK, Reue K, Smale ST, Yang X, Tontonoz P. Single cell analysis reveals immune cell-adipocyte crosstalk regulating the transcription of thermogenic adipocytes.Link is external (Link is external) (Link opens in new window) . eLife, 2019. Hu X, Weston TA, He C, Jung RS, Heizer PJ, Young BD, Tu Y, Tontonoz P, Wohlschlegel JA, Jiang H, Young SG, Fong LG. Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia.Link is external (Link is external) (Link opens in new window) . eLife, 2019. Pearson S, Loft A, Rajbhandari P, Simcox J, Lee S, Tontonoz P, Mandrup S, Villanueva CJ. Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism.Link is external (Link is external) (Link opens in new window) . Genes & development, 2019. Bl?zquez-Medela AM, Jumabay M, Rajbhandari P, Sallam T, Guo Y, Yao J, Vergnes L, Reue K, Zhang L, Yao Y, Fogelman AM, Tontonoz P, Lusis AJ, Wu X, Bostr?m KI. Noggin depletion in adipocytes promotes obesity in mice.Link is external (Link is external) (Link opens in new window) . Molecular metabolism, 2019. Ram?n-V?zquez A, de la Rosa JV, Tabraue C, Lopez F, D?az-Chico BN, Bosca L, Tontonoz P, Alemany S, Castrillo A. Common and Differential Transcriptional Actions of Nuclear Receptors Liver X Receptors a and � in Macrophages.Link is external (Link is external) (Link opens in new window) . Molecular and cellular biology, 2019. Sallam T, Tontonoz P. Lnc-ing microRNA activity to atheroprotection.Link is external (Link is external) (Link opens in new window) . Nature metabolism, 2019. Zhang P, Csaki LS, Ronquillo E, Baufeld LJ, Lin JY, Gutierrez A, Dwyer JR, Brindley DN, Fong LG, Tontonoz P, Young SG, Reue K. Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis.Link is external (Link is external) (Link opens in new window) . The Journal of clinical investigation, 2018. Wang B, Tontonoz P. Phospholipid Remodeling in Physiology and Disease.Link is external (Link is external) (Link opens in new window) . Annual review of physiology, 2018. He C, Hu X, Weston TA, Jung RS, Heizer P, Tu Y, Ellison R, Matsumoto K, Gerhardt H, Tontonoz P, Fong LG, Young SG, Jiang H. NanoSIMS imaging reveals unexpected heterogeneity in nutrient uptake by brown adipocytes.Link is external (Link is external) (Link opens in new window) . Biochemical and biophysical research communications, 2018. Sandhu J, Li S, Fairall L, Pfisterer SG, Gurnett JE, Xiao X, Weston TA, Vashi D, Ferrari A, Orozco JL, Hartman CL, Strugatsky D, Lee SD, He C, Hong C, Jiang H, Bentolila LA, Gatta AT, Levine TP, Ferng A, Lee R, Ford DA, Young SG, Ikonen E, Schwabe JWR, Tontonoz P. Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.Link is external (Link is external) (Link opens in new window) . Cell, 2018. He C, Hu X, Weston TA, Jung RS, Sandhu J, Huang S, Heizer P, Kim J, Ellison R, Xu J, Kilburn M, Bensinger SJ, Riezman H, Tontonoz P, Fong LG, Jiang H, Young SG. Macrophages release plasma membrane-derived particles rich in accessible cholesterol.Link is external (Link is external) (Link opens in new window) . Proceedings of the National Academy of Sciences of the United States of America, 2018. Wang B, Tontonoz P. Liver X receptors in lipid signalling and membrane homeostasis.Link is external (Link is external) (Link opens in new window) . Nature reviews. Endocrinology, 2018. Seldin MM, Koplev S, Rajbhandari P, Vergnes L, Rosenberg GM, Meng Y, Pan C, Phuong TMN, Gharakhanian R, Che N, Mäkinen S, Shih DM, Civelek M, Parks BW, Kim ED, Norheim F, Chella Krishnan K, Hasin-Brumshtein Y, Mehrabian M, Laakso M, Drevon CA, Koistinen HA, Tontonoz P, Reue K, Cantor RM, Björkegren JLM, Lusis AJ. A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism.Link is external (Link is external) (Link opens in new window) . Cell metabolism, 2018. He C, Weston TA, Jung RS, Heizer P, Larsson M, Hu X, Allan CM, Tontonoz P, Reue K, Beigneux AP, Ploug M, Holme A, Kilburn M, Guagliardo P, Ford DA, Fong LG, Young SG, Jiang H. NanoSIMS Analysis of Intravascular Lipolysis and Lipid Movement across Capillaries and into Cardiomyocytes.Link is external (Link is external) (Link opens in new window) . Cell metabolism, 2018. Beceiro S, Pap A, Czimmerer Z, Sallam T, Guill?n JA, Gallardo G, Hong C, A-Gonzalez N, Tabraue C, Diaz M, Lopez F, Matalonga J, Valledor AF, Dominguez P, Ardavin C, Delgado-Martin C, Partida-Sanchez S, Rodriguez-Fernandez JL, Nagy L, Tontonoz P, Castrillo A. Liver X Receptor Nuclear Receptors Are Transcriptional Regulators of Dendritic Cell Chemotaxis.Link is external (Link is external) (Link opens in new window) . Molecular and cellular biology, 2018. Sallam T, Jones M, Thomas BJ, Wu X, Gilliland T, Qian K, Eskin A, Casero D, Zhang Z, Sandhu J, Salisbury D, Rajbhandari P, Civelek M, Hong C, Ito A, Liu X, Daniel B, Lusis AJ, Whitelegge J, Nagy L, Castrillo A, Smale S, Tontonoz P. Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA.Link is external (Link is external) (Link opens in new window) . Nature medicine, 2018. Wang B, Rong X, Palladino END, Wang J, Fogelman AM, Mart?n MG, Alrefai WA, Ford DA, Tontonoz P. Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis.Link is external (Link is external) (Link opens in new window) . Cell stem cell, 2018. Zhou Z, Ribas V, Rajbhandari P, Drew BG, Moore TM, Fluitt AH, Reddish BR, Whitney KA, Georgia S, Vergnes L, Reue K, Liesa M, Shirihai O, van der Bliek AM, Chi NW, Mahata SK, Tiano JP, Hewitt SC, Tontonoz P, Korach KS, Mauvais-Jarvis F, Hevener AL. Estrogen receptor a protects pancreatic �-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress.Link is external (Link is external) (Link opens in new window) . The Journal of biological chemistry, 2018. Sallam T, Sandhu J, Tontonoz P. Long Noncoding RNA Discovery in Cardiovascular Disease: Decoding Form to Function.Link is external (Link is external) (Link opens in new window) . Circulation research, 2018. Bornfeldt KE, Kramer F, Batorsky A, Choi J, Hudkins KL, Tontonoz P, Alpers CE, Kanter JE. A Novel Type 2 Diabetes Mouse Model of Combined Diabetic Kidney Disease and Atherosclerosis.Link is external (Link is external) (Link opens in new window) . The American journal of pathology, 2017. Rajbhandari P, Thomas BJ, Feng AC, Hong C, Wang J, Vergnes L, Sallam T, Wang B, Sandhu J, Seldin MM, Lusis AJ, Fong LG, Katz M, Lee R, Young SG, Reue K, Smale ST, Tontonoz P. IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure.Link is external (Link is external) (Link opens in new window) . Cell, 2017. Zhang L, Rajbhandari P, Priest C, Sandhu J, Wu X, Temel R, Castrillo A, de Aguiar Vallim TQ, Sallam T, Tontonoz P. Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP.Link is external (Link is external) (Link opens in new window) . eLife, 2017. Gao J, Marosi M, Choi J, Achiro JM, Kim S, Li S, Otis K, Martin KC, Portera-Cailliau C, Tontonoz P. The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning.Link is external (Link is external) (Link opens in new window) . eLife, 2017. Rong X, Wang B, Palladino EN, de Aguiar Vallim TQ, Ford DA, Tontonoz P. ER phospholipid composition modulates lipogenesis during feeding and in obesity.Link is external (Link is external) (Link opens in new window) . The Journal of clinical investigation, 2017. Yao J, Guihard PJ, Wu X, Blazquez-Medela AM, Spencer MJ, Jumabay M, Tontonoz P, Fogelman AM, Bostr?m KI, Yao Y. Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation.Link is external (Link is external) (Link opens in new window) . The Journal of cell biology, 2017. Tontonoz P, Wu X, Jones M, Zhang Z, Salisbury D, Sallam T. Long Noncoding RNA Facilitated Gene Therapy Reduces Atherosclerosis in a Murine Model of Familial Hypercholesterolemia.Link is external (Link is external) (Link opens in new window) . Circulation, 2017. Price TR, Moncada K, Leyva-Jimenez H, Park KW, Tontonoz P, Walzem RL. Phenamil, an amiloride derivative, restricts long bone growth and alters keeled-sternum bone architecture in growing chickens.Link is external (Link is external) (Link opens in new window) . Poultry science, 2017. Mukherjee P, Hough G, Chattopadhyay A, Navab M, Fogelman HR, Meriwether D, Williams K, Bensinger S, Moller T, Faull KF, Lusis AJ, Iruela-Arispe ML, Bostrom KI, Tontonoz P, Reddy ST, Fogelman AM. Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum.Link is external (Link is external) (Link opens in new window) . Journal of lipid research, 2017. Beigneux AP, Miyashita K, Ploug M, Blom DJ, Ai M, Linton MF, Khovidhunkit W, Dufour R, Garg A, McMahon MA, Pullinger CR, Sandoval NP, Hu X, Allan CM, Larsson M, Machida T, Murakami M, Reue K, Tontonoz P, Goldberg IJ, Moulin P, Charri?re S, Fong LG, Nakajima K, Young SG. Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia.Link is external (Link is external) (Link opens in new window) . The New England journal of medicine, 2017. Wang J, Tontonoz P. Pioneering EBF2 remodels the brown fat chromatin landscape.Link is external (Link is external) (Link opens in new window) . Genes & development, 2017. Wang J, Rajbhandari P, Damianov A, Han A, Sallam T, Waki H, Villanueva CJ, Lee SD, Nielsen R, Mandrup S, Reue K, Young SG, Whitelegge J, Saez E, Black DL, Tontonoz P. RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs.Link is external (Link is external) (Link opens in new window) . The Journal of clinical investigation, 2017. He C, Hu X, Jung RS, Weston TA, Sandoval NP, Tontonoz P, Kilburn MR, Fong LG, Young SG, Jiang H. High-resolution imaging and quantification of plasma membrane cholesterol by NanoSIMS.Link is external (Link is external) (Link opens in new window) . Proceedings of the National Academy of Sciences of the United States of America, 2017. Ito A, Hong C, Oka K, Salazar JV, Diehl C, Witztum JL, Diaz M, Castrillo A, Bensinger SJ, Chan L, Tontonoz P. Cholesterol Accumulation in CD11c+ Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease.Link is external (Link is external) (Link opens in new window) . Immunity, 2016. Kim DH, Kim J, Kwon JS, Sandhu J, Tontonoz P, Lee SK, Lee S, Lee JW. Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPAR?2.Link is external (Link is external) (Link opens in new window) . Cell reports, 2016. Villa GR, Hulce JJ, Zanca C, Bi J, Ikegami S, Cahill GL, Gu Y, Lum KM, Masui K, Yang H, Rong X, Hong C, Turner KM, Liu F, Hon GC, Jenkins D, Martini M, Armando AM, Quehenberger O, Cloughesy TF, Furnari FB, Cavenee WK, Tontonoz P, Gahman TC, Shiau AK, Cravatt BF, Mischel PS. An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers.Link is external (Link is external) (Link opens in new window) . Cancer cell, 2016. Song NJ, Kim S, Jang BH, Chang SH, Yun UJ, Park KM, Waki H, Li DY, Tontonoz P, Park KW. Small Molecule-Induced Complement Factor D (Adipsin) Promotes Lipid Accumulation and Adipocyte Differentiation.Link is external (Link is external) (Link opens in new window) . PloS one, 2016. Sallam T, Jones MC, Gilliland T, Zhang L, Wu X, Eskin A, Sandhu J, Casero D, Vallim TQ, Hong C, Katz M, Lee R, Whitelegge J, Tontonoz P. Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis.Link is external (Link is external) (Link opens in new window) . Nature, 2016. Song NJ, Choi S, Rajbhandari P, Chang SH, Kim S, Vergnes L, Kwon SM, Yoon JH, Lee S, Ku JM, Lee JS, Reue K, Koo SH, Tontonoz P, Park KW. Prdm4 induction by the small molecule butein promotes white adipose tissue browning.Link is external (Link is external) (Link opens in new window) . Nature chemical biology, 2016. Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL. Skeletal muscle action of estrogen receptor a is critical for the maintenance of mitochondrial function and metabolic homeostasis in females.Link is external (Link is external) (Link opens in new window) . Science translational medicine, 2016. Wang B, Rong X, Duerr MA, Hermanson DJ, Hedde PN, Wong JS, Vallim TQ, Cravatt BF, Gratton E, Ford DA, Tontonoz P. Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet.Link is external (Link is external) (Link opens in new window) . Cell metabolism, 2016. Allan CM, Procaccia S, Tran D, Tu Y, Barnes RH, Larsson M, Allan BB, Young LC, Hong C, Tontonoz P, Fong LG, Young SG, Beigneux AP. Palmoplantar Keratoderma in Slurp2-Deficient Mice.Link is external (Link is external) (Link opens in new window) . The Journal of investigative dermatology, 2015. Choi J, Gao J, Kim J, Hong C, Kim J, Tontonoz P. The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and A� amyloidosis.Link is external (Link is external) (Link opens in new window) . Science translational medicine, 2015. Briot A, Civelek M, Seki A, Hoi K, Mack JJ, Lee SD, Kim J, Hong C, Yu J, Fishbein GA, Vakili L, Fogelman AM, Fishbein MC, Lusis AJ, Tontonoz P, Navab M, Berliner JA, Iruela-Arispe ML. Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis.Link is external (Link is external) (Link opens in new window) . The Journal of experimental medicine, 2015. Tian XY, Ganeshan K, Hong C, Nguyen KD, Qiu Y, Kim J, Tangirala RK, Tontonoz P, Tonotonoz P, Chawla A. Thermoneutral Housing Accelerates Metabolic Inflammation to Potentiate Atherosclerosis but Not Insulin Resistance.Link is external (Link is external) (Link opens in new window) . Cell metabolism, 2015. Ito A, Hong C, Rong X, Zhu X, Tarling EJ, Hedde PN, Gratton E, Parks J, Tontonoz P. LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling.Link is external (Link is external) (Link opens in new window) . eLife, 2015. Lee SD, Tontonoz P. Liver X receptors at the intersection of lipid metabolism and atherogenesis.Link is external (Link is external) (Link opens in new window) . Atherosclerosis, 2015. Rong X, Wang B, Dunham MM, Hedde PN, Wong JS, Gratton E, Young SG, Ford DA, Tontonoz P. Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion.Link is external (Link is external) (Link opens in new window) . eLife, 2015. Parks BW, Sallam T, Mehrabian M, Psychogios N, Hui ST, Norheim F, Castellani LW, Rau CD, Pan C, Phun J, Zhou Z, Yang WP, Neuhaus I, Gargalovic PS, Kirchgessner TG, Graham M, Lee R, Tontonoz P, Gerszten RE, Hevener AL, Lusis AJ. Genetic architecture of insulin resistance in the mouse.Link is external (Link is external) (Link opens in new window) . Cell metabolism, 2015. Tontonoz P, Cortez-Toledo O, Wroblewski K, Hong C, Lim L, Carranza R, Conneely O, Metzger D, Chao LC. The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice.Link is external (Link is external) (Link opens in new window) . Molecular and cellular biology, 2015. Warrier M, Shih DM, Burrows AC, Ferguson D, Gromovsky AD, Brown AL, Marshall S, McDaniel A, Schugar RC, Wang Z, Sacks J, Rong X, Vallim TA, Chou J, Ivanova PT, Myers DS, Brown HA, Lee RG, Crooke RM, Graham MJ, Liu X, Parini P, Tontonoz P, Lusis AJ, Hazen SL, Temel RE, Brown JM. The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance.Link is external (Link is external) (Link opens in new window) . Cell reports, 2015. Drew BG, Hamidi H, Zhou Z, Villanueva CJ, Krum SA, Calkin AC, Parks BW, Ribas V, Kalajian NY, Phun J, Daraei P, Christofk HR, Hewitt SC, Korach KS, Tontonoz P, Lusis AJ, Slamon DJ, Hurvitz SA, Hevener AL. Estrogen receptor (ER)a-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression.Link is external (Link is external) (Link opens in new window) . The Journal of biological chemistry, 2014. Ma F, Liu SY, Razani B, Arora N, Li B, Kagechika H, Tontonoz P, N??ez V, Ricote M, Cheng G. Retinoid X receptor a attenuates host antiviral response by suppressing type I interferon.Link is external (Link is external) (Link opens in new window) . Nature communications, 2014. Hong C, Marshall SM, McDaniel AL, Graham M, Layne JD, Cai L, Scotti E, Boyadjian R, Kim J, Chamberlain BT, Tangirala RK, Jung ME, Fong L, Lee R, Young SG, Temel RE, Tontonoz P. The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice.Link is external (Link is external) (Link opens in new window) . Cell metabolism, 2014. Priest C, Tontonoz P. SUMOylation places LRH-1 in PROXimity to lipid metabolism.Link is external (Link is external) (Link opens in new window) . Cell metabolism, 2014. Jones M, Tontonoz P. Enhanced thermogenesis in the blinc of an eye.Link is external (Link is external) (Link opens in new window) . Molecular cell, 2014. Tontonoz P. 2014 American Society for Clinical Investigation Presidential Address. Leading by example: pastors, mentors, physician-scientists, and the ASCI.Link is external (Link is external) (Link opens in new window) . The Journal of clinical investigation, 2014. Chung S, Cuffe H, Marshall SM, McDaniel AL, Ha JH, Kavanagh K, Hong C, Tontonoz P, Temel RE, Parks JS. Dietary cholesterol promotes adipocyte hypertrophy and adipose tissue inflammation in visceral, but not in subcutaneous, fat in monkeys.Link is external (Link is external) (Link opens in new window) . Arteriosclerosis, thrombosis, and vascular biology, 2014. Calkin AC, Lee SD, Kim J, Van Stijn CM, Wu XH, Lusis AJ, Hong C, Tangirala RI, Tontonoz P. Transgenic expression of dominant-active IDOL in liver causes diet-induced hypercholesterolemia and atherosclerosis in mice.Link is external (Link is external) (Link opens in new window) . Circulation research, 2014. Lee SD, Tontonoz P. Eosinophils in fat: pink is the new brown.Link is external (Link is external) (Link opens in new window) . Cell, 2014. Hong C, Tontonoz P. Liver X receptors in lipid metabolism: opportunities for drug discovery.Link is external (Link is external) (Link opens in new window) . Nature reviews. Drug discovery, 2014. Goulbourne CN, Gin P, Tatar A, Nobumori C, Hoenger A, Jiang H, Grovenor CR, Adeyo O, Esko JD, Goldberg IJ, Reue K, Tontonoz P, Bensadoun A, Beigneux AP, Young SG, Fong LG. The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries.Link is external (Link is external) (Link opens in new window) . Cell metabolism, 2014. Sallam T, Ito A, Rong X, Kim J, van Stijn C, Chamberlain BT, Jung ME, Chao LC, Jones M, Gilliland T, Wu X, Su GL, Tangirala RK, Tontonoz P, Hong C. The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis.Link is external (Link is external) (Link opens in new window) . Journal of lipid research, 2014. Tessem JS, Moss LG, Chao LC, Arlotto M, Lu D, Jensen MV, Stephens SB, Tontonoz P, Hohmeier HE, Newgard CB. Nkx6.1 regulates islet �-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors.Link is external (Link is external) (Link opens in new window) . Proceedings of the National Academy of Sciences of the United States of America, 2014. Goddard LM, Murphy TJ, Org T, Enciso JM, Hashimoto-Partyka MK, Warren CM, Domigan CK, McDonald AI, He H, Sanchez LA, Allen NC, Orsenigo F, Chao LC, Dejana E, Tontonoz P, Mikkola HK, Iruela-Arispe ML. Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation.Link is external (Link is external) (Link opens in new window) . Cell, 2014. Adeyo O, Allan BB, Barnes RH, Goulbourne CN, Tatar A, Tu Y, Young LC, Weinstein MM, Tontonoz P, Fong LG, Beigneux AP, Young SG. Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice.Link is external (Link is external) (Link opens in new window) . The Journal of investigative dermatology, 2014. Hamada M, Nakamura M, Tran MT, Moriguchi T, Hong C, Ohsumi T, Dinh TT, Kusakabe M, Hattori M, Katsumata T, Arai S, Nakashima K, Kudo T, Kuroda E, Wu CH, Kao PH, Sakai M, Shimano H, Miyazaki T, Tontonoz P, Takahashi S. MafB promotes atherosclerosis by inhibiting foam-cell apoptosis.Link is external (Link is external) (Link opens in new window) . Nature communications, 2014. Rong X, Albert CJ, Hong C, Duerr MA, Chamberlain BT, Tarling EJ, Ito A, Gao J, Wang B, Edwards PA, Jung ME, Ford DA, Tontonoz P. LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition.Link is external (Link is external) (Link opens in new window) . Cell metabolism, 2013. Fan J, Shimizu Y, Chan J, Wilkinson A, Ito A, Tontonoz P, Dullaghan E, Galea LA, Pfeifer T, Wellington CL. Hormonal modulators of glial ABCA1 and apoE levels.Link is external (Link is external) (Link opens in new window) . Journal of lipid research, 2013. Beaven SW, Matveyenko A, Wroblewski K, Chao L, Wilpitz D, Hsu TW, Lentz J, Drew B, Hevener AL, Tontonoz P. Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance.Link is external (Link is external) (Link opens in new window) . Cell metabolism, 2013. A-Gonzalez N, Guillen JA, Gallardo G, Diaz M, de la Rosa JV, Hernandez IH, Casanova-Acebes M, Lopez F, Tabraue C, Beceiro S, Hong C, Lara PC, Andujar M, Arai S, Miyazaki T, Li S, Corbi AL, Tontonoz P, Hidalgo A, Castrillo A. The nuclear receptor LXRa controls the functional specialization of splenic macrophages.Link is external (Link is external) (Link opens in new window) . Nature immunology, 2013. Csaki LS, Dwyer JR, Fong LG, Tontonoz P, Young SG, Reue K. Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling.Link is external (Link is external) (Link opens in new window) . Progress in lipid research, 2013. Villanueva CJ, Vergnes L, Wang J, Drew BG, Hong C, Tu Y, Hu Y, Peng X, Xu F, Saez E, Wroblewski K, Hevener AL, Reue K, Fong LG, Young SG, Tontonoz P. Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPAR? specifies lipid storage versus thermogenic gene programs.Link is external (Link is external) (Link opens in new window) . Cell metabolism, 2013. Zhang L, Xu M, Scotti E, Chen ZJ, Tontonoz P. Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor.Link is external (Link is external) (Link opens in new window) . Journal of lipid research, 2013. Scotti E, Calamai M, Goulbourne CN, Zhang L, Hong C, Lin RR, Choi J, Pilch PF, Fong LG, Zou P, Ting AY, Pavone FS, Young SG, Tontonoz P. IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor.Link is external (Link is external) (Link opens in new window) . Molecular and cellular biology, 2013. Choi J, Tontonoz P. Metabolism: Drug discovery goes for a swim.Link is external (Link is external) (Link opens in new window) . Nature chemical biology, 2013. Chao LC, Soto E, Hong C, Ito A, Pei L, Chawla A, Conneely OM, Tangirala RK, Evans RM, Tontonoz P. Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice.Link is external (Link is external) (Link opens in new window) . Journal of lipid research, 2013. Halperin DS, Pan C, Lusis AJ, Tontonoz P. Vestigial-like 3 is an inhibitor of adipocyte differentiation.Link is external (Link is external) (Link opens in new window) . Journal of lipid research, 2012. Chao LC, Wroblewski K, Ilkayeva OR, Stevens RD, Bain J, Meyer GA, Schenk S, Martinez L, Vergnes L, Narkar VA, Drew BG, Hong C, Boyadjian R, Hevener AL, Evans RM, Reue K, Spencer MJ, Newgard CB, Tontonoz P. Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization.Link is external (Link is external) (Link opens in new window) . Journal of lipid research, 2012. Zhang L, Reue K, Fong LG, Young SG, Tontonoz P. Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis.Link is external (Link is external) (Link opens in new window) . Arteriosclerosis, thrombosis, and vascular biology, 2012. Chen X, McClusky R, Chen J, Beaven SW, Tontonoz P, Arnold AP, Reue K. The number of x chromosomes causes sex differences in adiposity in mice.Link is external (Link is external) (Link opens in new window) . PLoS genetics, 2012. Hong C, Bradley MN, Rong X, Wang X, Wagner A, Grijalva V, Castellani LW, Salazar J, Realegeno S, Boyadjian R, Fogelman AM, Van Lenten BJ, Reddy ST, Lusis AJ, Tangirala RK, Tontonoz P. LXRa is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice.Link is external (Link is external) (Link opens in new window) . Journal of lipid research, 2012. Calkin AC, Tontonoz P. Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR.Link is external (Link is external) (Link opens in new window) . Nature reviews. Molecular cell biology, 2012. Chao LC, Tontonoz P. SIRT1 regulation-it ain't all NAD.Link is external (Link is external) (Link opens in new window) . Molecular cell, 2012. Weinstein MM, Goulbourne CN, Davies BS, Tu Y, Barnes RH, Watkins SM, Davis R, Reue K, Tontonoz P, Beigneux AP, Fong LG, Young SG. Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice.Link is external (Link is external) (Link opens in new window) . Arteriosclerosis, thrombosis, and vascular biology, 2011. Hong C, Kidani Y, A-Gonzalez N, Phung T, Ito A, Rong X, Ericson K, Mikkola H, Beaven SW, Miller LS, Shao WH, Cohen PL, Castrillo A, Tontonoz P, Bensinger SJ. Coordinate regulation of neutrophil homeostasis by liver X receptors in mice.Link is external (Link is external) (Link opens in new window) . The Journal of clinical investigation, 2011. Calkin AC, Goult BT, Zhang L, Fairall L, Hong C, Schwabe JW, Tontonoz P. FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors.Link is external (Link is external) (Link opens in new window) . Proceedings of the National Academy of Sciences of the United States of America, 2011. Guo D, Reinitz F, Youssef M, Hong C, Nathanson D, Akhavan D, Kuga D, Amzajerdi AN, Soto H, Zhu S, Babic I, Tanaka K, Dang J, Iwanami A, Gini B, Dejesus J, Lisiero DD, Huang TT, Prins RM, Wen PY, Robins HI, Prados MD, Deangelis LM, Mellinghoff IK, Mehta MP, James CD, Chakravarti A, Cloughesy TF, Tontonoz P, Mischel PS. An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway.Link is external (Link is external) (Link opens in new window) . Cancer discovery, 2011. Tontonoz P. Transcriptional and posttranscriptional control of cholesterol homeostasis by liver X receptors.Link is external (Link is external) (Link opens in new window) . Cold Spring Harbor symposia on quantitative biology, 2011. Young SG, Davies BS, Voss CV, Gin P, Weinstein MM, Tontonoz P, Reue K, Bensadoun A, Fong LG, Beigneux AP. GPIHBP1, an endothelial cell transporter for lipoprotein lipase.Link is external (Link is external) (Link opens in new window) . Journal of lipid research, 2011. Weissglas-Volkov D, Calkin AC, Tusie-Luna T, Sinsheimer JS, Zelcer N, Riba L, Tino AM, Ordo?ez-S?nchez ML, Cruz-Bautista I, Aguilar-Salinas CA, Tontonoz P, Pajukanta P. The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans.Link is external (Link is external) (Link opens in new window) . The Journal of clinical investigation, 2011. Zhang L, Fairall L, Goult BT, Calkin AC, Hong C, Millard CJ, Tontonoz P, Schwabe JW. The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.Link is external (Link is external) (Link opens in new window) . Genes & development, 2011. Villanueva CJ, Waki H, Godio C, Nielsen R, Chou WL, Vargas L, Wroblewski K, Schmedt C, Chao LC, Boyadjian R, Mandrup S, Hevener A, Saez E, Tontonoz P. TLE3 is a dual-function transcriptional coregulator of adipogenesis.Link is external (Link is external) (Link opens in new window) . Cell metabolism, 2011. Scotti E, Hong C, Yoshinaga Y, Tu Y, Hu Y, Zelcer N, Boyadjian R, de Jong PJ, Young SG, Fong LG, Tontonoz P. Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists.Link is external (Link is external) (Link opens in new window) . Molecular and cellular biology, 2011. Hong C, Walczak R, Dhamko H, Bradley MN, Marathe C, Boyadjian R, Salazar JV, Tontonoz P. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target.Link is external (Link is external) (Link opens in new window) . Journal of lipid research, 2010. Beaven SW, Wroblewski K, Wang J, Hong C, Bensinger S, Tsukamoto H, Tontonoz P. Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease.Link is external (Link is external) (Link opens in new window) . Gastroenterology, 2010. Feig JE, Pineda-Torra I, Sanson M, Bradley MN, Vengrenyuk Y, Bogunovic D, Gautier EL, Rubinstein D, Hong C, Liu J, Wu C, van Rooijen N, Bhardwaj N, Garabedian M, Tontonoz P, Fisher EA. LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression.Link is external (Link is external) (Link opens in new window) . The Journal of clinical investigation, 2010. Villanueva CJ, Tontonoz P. Licensing PPAR? to work in macrophages.Link is external (Link is external) (Link opens in new window) . Immunity, 2010. Bruhn KW, Marathe C, Maretti-Mira AC, Nguyen H, Haskell J, Tran TA, Vanchinathan V, Gaur U, Wilson ME, Tontonoz P, Craft N. LXR deficiency confers increased protection against visceral Leishmania infection in mice.Link is external (Link is external) (Link opens in new window) . PLoS neglected tropical diseases, 2010. Calkin AC, Tontonoz P. Genome-wide association studies identify new targets in cardiovascular disease.Link is external (Link is external) (Link opens in new window) . Science translational medicine, 2010. Weinstein MM, Tu Y, Beigneux AP, Davies BS, Gin P, Voss C, Walzem RL, Reue K, Tontonoz P, Bensadoun A, Fong LG, Young SG. Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice.Link is external (Link is external) (Link opens in new window) . Arteriosclerosis, thrombosis, and vascular biology, 2010. Calkin AC, Tontonoz P. Liver x receptor signaling pathways and atherosclerosis.Link is external (Link is external) (Link opens in new window) . Arteriosclerosis, thrombosis, and vascular biology, 2010. Park KW, Waki H, Choi SP, Park KM, Tontonoz P. The small molecule phenamil is a modulator of adipocyte differentiation and PPARgamma expression.Link is external (Link is external) (Link opens in new window) . Journal of lipid research, 2010. Hong C, Duit S, Jalonen P, Out R, Scheer L, Sorrentino V, Boyadjian R, Rodenburg KW, Foley E, Korhonen L, Lindholm D, Nimpf J, van Berkel TJ, Tontonoz P, Zelcer N. The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.Link is external (Link is external) (Link opens in new window) . The Journal of biological chemistry, 2010. Scotti E, Tontonoz P. Peroxisome proliferator-activated receptor gamma dances with different partners in macrophage and adipocytes.Link is external (Link is external) (Link opens in new window) . Molecular and cellular biology, 2010. Chao LC, Wroblewski K, Zhang Z, Pei L, Vergnes L, Ilkayeva OR, Ding SY, Reue K, Watt MJ, Newgard CB, Pilch PF, Hevener AL, Tontonoz P. Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77.Link is external (Link is external) (Link opens in new window) . Diabetes, 2009. A-Gonzalez N, Bensinger SJ, Hong C, Beceiro S, Bradley MN, Zelcer N, Deniz J, Ramirez C, Díaz M, Gallardo G, de Galarreta CR, Salazar J, Lopez F, Edwards P, Parks J, Andujar M, Tontonoz P, Castrillo A. Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.Link is external (Link is external) (Link opens in new window) . Immunity, 2009. Kim WK, Meliton V, Park KW, Hong C, Tontonoz P, Niewiadomski P, Waschek JA, Tetradis S, Parhami F. Negative regulation of Hedgehog signaling by liver X receptors.Link is external (Link is external) (Link opens in new window) . Molecular endocrinology (Baltimore, Md.), 2009. Zelcer N, Hong C, Boyadjian R, Tontonoz P. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor.Link is external (Link is external) (Link opens in new window) . Science (New York, N.Y.), 2009. Dean JT, Tran L, Beaven S, Tontonoz P, Reue K, Dipple KM, Liao JC. Resistance to diet-induced obesity in mice with synthetic glyoxylate shunt.Link is external (Link is external) (Link opens in new window) . Cell metabolism, 2009. Park KW, Waki H, Kim WK, Davies BS, Young SG, Parhami F, Tontonoz P. The small molecule phenamil induces osteoblast differentiation and mineralization.Link is external (Link is external) (Link opens in new window) . Molecular and cellular biology, 2009. Bensinger SJ, Tontonoz P. A Nurr1 pathway for neuroprotection.Link is external (Link is external) (Link opens in new window) . Cell, 2009. Hsu JJ, Lu J, Huang MS, Geng Y, Sage AP, Bradley MN, Tontonoz P, Demer LL, Tintut Y. T0901317, an LXR agonist, augments PKA-induced vascular cell calcification.Link is external (Link is external) (Link opens in new window) . FEBS letters, 2009. Park KW, Halperin DS, Tontonoz P. Before they were fat: adipocyte progenitors.Link is external (Link is external) (Link opens in new window) . Cell metabolism, 2008. Naiki Y, Sorrentino R, Wong MH, Michelsen KS, Shimada K, Chen S, Yilmaz A, Slepenkin A, Schröder NW, Crother TR, Bulut Y, Doherty TM, Bradley M, Shaposhnik Z, Peterson EM, Tontonoz P, Shah PK, Arditi M. TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis.Link is external (Link is external) (Link opens in new window) . Journal of immunology (Baltimore, Md. : 1950), 2008. Chao LC, Bensinger SJ, Villanueva CJ, Wroblewski K, Tontonoz P. Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1.Link is external (Link is external) (Link opens in new window) . Molecular endocrinology (Baltimore, Md.), 2008. Davies BS, Waki H, Beigneux AP, Farber E, Weinstein MM, Wilpitz DC, Tai LJ, Evans RM, Fong LG, Tontonoz P, Young SG. The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma.Link is external (Link is external) (Link opens in new window) . Molecular endocrinology (Baltimore, Md.), 2008. Hong C, Tontonoz P. Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors.Link is external (Link is external) (Link opens in new window) . Current opinion in genetics & development, 2008. Marathe C, Bradley MN, Hong C, Chao L, Wilpitz D, Salazar J, Tontonoz P. Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARgamma-/-, PPARdelta-/-, PPARgammadelta-/-, or LXRalphabeta-/- bone marrow.Link is external (Link is external) (Link opens in new window) . Journal of lipid research, 2008. Hummasti S, Hong C, Bensinger SJ, Tontonoz P. HRASLS3 is a PPARgamma-selective target gene that promotes adipocyte differentiation.Link is external (Link is external) (Link opens in new window) . Journal of lipid research, 2008. Bensinger SJ, Tontonoz P. Integration of metabolism and inflammation by lipid-activated nuclear receptors.Link is external (Link is external) (Link opens in new window) . Nature, 2008. Bensinger SJ, Bradley MN, Joseph SB, Zelcer N, Janssen EM, Hausner MA, Shih R, Parks JS, Edwards PA, Jamieson BD, Tontonoz P. LXR signaling couples sterol metabolism to proliferation in the acquired immune response.Link is external (Link is external) (Link opens in new window) . Cell, 2008. Park KW, Waki H, Villanueva CJ, Monticelli LA, Hong C, Kang S, MacDougald OA, Goldrath AW, Tontonoz P. Inhibitor of DNA binding 2 is a small molecule-inducible modulator of peroxisome proliferator-activated receptor-gamma expression and adipocyte differentiation.Link is external (Link is external) (Link opens in new window) . Molecular endocrinology (Baltimore, Md.), 2008. Jiang Q, Lee CY, Mandrekar S, Wilkinson B, Cramer P, Zelcer N, Mann K, Lamb B, Willson TM, Collins JL, Richardson JC, Smith JD, Comery TA, Riddell D, Holtzman DM, Tontonoz P, Landreth GE. ApoE promotes the proteolytic degradation of Abeta.Link is external (Link is external) (Link opens in new window) . Neuron, 2008. Gallardo-Soler A, Gómez-Nieto C, Campo ML, Marathe C, Tontonoz P, Castrillo A, Corraliza I. Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity.Link is external (Link is external) (Link opens in new window) . Molecular endocrinology (Baltimore, Md.), 2008. Hummasti S, Tontonoz P. Adopting new orphans into the family of metabolic regulators.Link is external (Link is external) (Link opens in new window) . Molecular endocrinology (Baltimore, Md.), 2008. Tontonoz P, Spiegelman BM. Fat and beyond: the diverse biology of PPARgamma.Link is external (Link is external) (Link opens in new window) . Annual review of biochemistry, 2008. Bradley MN, Hong C, Chen M, Joseph SB, Wilpitz DC, Wang X, Lusis AJ, Collins A, Hseuh WA, Collins JL, Tangirala RK, Tontonoz P. Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE.Link is external (Link is external) (Link opens in new window) . The Journal of clinical investigation, 2007. Molteni V, Li X, Nabakka J, Liang F, Wityak J, Koder A, Vargas L, Romeo R, Mitro N, Mak PA, Seidel HM, Haslam JA, Chow D, Tuntland T, Spalding TA, Brock A, Bradley M, Castrillo A, Tontonoz P, Saez E. N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta.Link is external (Link is external) (Link opens in new window) . Journal of medicinal chemistry, 2007. Zelcer N, Khanlou N, Clare R, Jiang Q, Reed-Geaghan EG, Landreth GE, Vinters HV, Tontonoz P. Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors.Link is external (Link is external) (Link opens in new window) . Proceedings of the National Academy of Sciences of the United States of America, 2007. Chao LC, Zhang Z, Pei L, Saito T, Tontonoz P, Pilch PF. Nur77 coordinately regulates expression of genes linked to glucose metabolism in skeletal muscle.Link is external (Link is external) (Link opens in new window) . Molecular endocrinology (Baltimore, Md.), 2007. Waki H, Tontonoz P. STAMPing out Inflammation.Link is external (Link is external) (Link opens in new window) . Cell, 2007. Waki H, Park KW, Mitro N, Pei L, Damoiseaux R, Wilpitz DC, Reue K, Saez E, Tontonoz P. The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression.Link is external (Link is external) (Link opens in new window) . Cell metabolism, 2007. Waki H, Tontonoz P. Endocrine functions of adipose tissue.Link is external (Link is external) (Link opens in new window) . Annual review of pathology, 2007. Cao F, Castrillo A, Tontonoz P, Re F, Byrne GI. Chlamydia pneumoniae--induced macrophage foam cell formation is mediated by Toll-like receptor 2.Link is external (Link is external) (Link opens in new window) . Infection and immunity, 2006. Blaschke F, Takata Y, Caglayan E, Collins A, Tontonoz P, Hsueh WA, Tangirala RK. A nuclear receptor corepressor-dependent pathway mediates suppression of cytokine-induced C-reactive protein gene expression by liver X receptor.Link is external (Link is external) (Link opens in new window) . Circulation research, 2006. Chow EK, Castrillo A, Shahangian A, Pei L, O'Connell RM, Modlin RL, Tontonoz P, Cheng G. A role for IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections.Link is external (Link is external) (Link opens in new window) . The Journal of experimental medicine, 2006. Marathe C, Bradley MN, Hong C, Lopez F, Ruiz de Galarreta CM, Tontonoz P, Castrillo A. The arginase II gene is an anti-inflammatory target of liver X receptor in macrophages.Link is external (Link is external) (Link opens in new window) . The Journal of biological chemistry, 2006. Pei L, Waki H, Vaitheesvaran B, Wilpitz DC, Kurland IJ, Tontonoz P. NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism.Link is external (Link is external) (Link opens in new window) . Nature medicine, 2006. Chen M, Bradley MN, Beaven SW, Tontonoz P. Phosphorylation of the liver X receptors.Link is external (Link is external) (Link opens in new window) . FEBS letters, 2006. Baldán A, Pei L, Lee R, Tarr P, Tangirala RK, Weinstein MM, Frank J, Li AC, Tontonoz P, Edwards PA. Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow.Link is external (Link is external) (Link opens in new window) . Arteriosclerosis, thrombosis, and vascular biology, 2006. Hummasti S, Tontonoz P. The peroxisome proliferator-activated receptor N-terminal domain controls isotype-selective gene expression and adipogenesis.Link is external (Link is external) (Link opens in new window) . Molecular endocrinology (Baltimore, Md.), 2006. Zelcer N, Tontonoz P. Liver X receptors as integrators of metabolic and inflammatory signaling.Link is external (Link is external) (Link opens in new window) . The Journal of clinical investigation, 2006. Beaven SW, Tontonoz P. Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia.Link is external (Link is external) (Link opens in new window) . Annual review of medicine, 2006. Pei L, Castrillo A, Tontonoz P. Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77.Link is external (Link is external) (Link opens in new window) . Molecular endocrinology (Baltimore, Md.), 2005. Zelcer N, Tontonoz P. SUMOylation and PPARgamma: wrestling with inflammatory signaling.Link is external (Link is external) (Link opens in new window) . Cell metabolism, 2005. Chen M, Beaven S, Tontonoz P. Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha.Link is external (Link is external) (Link opens in new window) . Journal of lipid research, 2005. Pei L, Castrillo A, Chen M, Hoffmann A, Tontonoz P. Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli.Link is external (Link is external) (Link opens in new window) . The Journal of biological chemistry, 2005. Arai S, Shelton JM, Chen M, Bradley MN, Castrillo A, Bookout AL, Mak PA, Edwards PA, Mangelsdorf DJ, Tontonoz P, Miyazaki T. A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development.Link is external (Link is external) (Link opens in new window) . Cell metabolism, 2005. Lin J, Yang R, Tarr PT, Wu PH, Handschin C, Li S, Yang W, Pei L, Uldry M, Tontonoz P, Newgard CB, Spiegelman BM. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.Link is external (Link is external) (Link opens in new window) . Cell, 2005. Bradley MN, Tontonoz P. Lesion macrophages are a key target for the antiatherogenic effects of LXR agonists.Link is external (Link is external) (Link opens in new window) . Arteriosclerosis, thrombosis, and vascular biology, 2005. Castrillo A, Tontonoz P. PPARs in atherosclerosis: the clot thickens.Link is external (Link is external) (Link opens in new window) . The Journal of clinical investigation, 2004. Sheth SS, Castellani LW, Chari S, Wagg C, Thipphavong CK, Bodnar JS, Tontonoz P, Attie AD, Lopaschuk GD, Lusis AJ. Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition.Link is external (Link is external) (Link opens in new window) . Journal of lipid research, 2004. Joseph SB, Bradley MN, Castrillo A, Bruhn KW, Mak PA, Pei L, Hogenesch J, O'connell RM, Cheng G, Saez E, Miller JF, Tontonoz P. LXR-dependent gene expression is important for macrophage survival and the innate immune response.Link is external (Link is external) (Link opens in new window) . Cell, 2004. Pei L, Tontonoz P. Fat's loss is bone's gain.Link is external (Link is external) (Link opens in new window) . The Journal of clinical investigation, 2004. Hummasti S, Laffitte BA, Watson MA, Galardi C, Chao LC, Ramamurthy L, Moore JT, Tontonoz P. Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target.Link is external (Link is external) (Link opens in new window) . Journal of lipid research, 2004. Castrillo A, Tontonoz P. Nuclear receptors in macrophage biology: at the crossroads of lipid metabolism and inflammation.Link is external (Link is external) (Link opens in new window) . Annual review of cell and developmental biology, 2004. Walczak R, Joseph SB, Laffitte BA, Castrillo A, Pei L, Tontonoz P. Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors.Link is external (Link is external) (Link opens in new window) . The Journal of biological chemistry, 2003. Walczak R, Tontonoz P. Setting fat on fire.Link is external (Link is external) (Link opens in new window) . Nature medicine, 2003. Castrillo A, Joseph SB, Vaidya SA, Haberland M, Fogelman AM, Cheng G, Tontonoz P. Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism.Link is external (Link is external) (Link opens in new window) . Molecular cell, 2003. Laffitte BA, Chao LC, Li J, Walczak R, Hummasti S, Joseph SB, Castrillo A, Wilpitz DC, Mangelsdorf DJ, Collins JL, Saez E, Tontonoz P. Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue.Link is external (Link is external) (Link opens in new window) . Proceedings of the National Academy of Sciences of the United States of America, 2003. Tontonoz P, Mangelsdorf DJ. Liver X receptor signaling pathways in cardiovascular disease.Link is external (Link is external) (Link opens in new window) . Molecular endocrinology (Baltimore, Md.), 2003. Joseph SB, Tontonoz P. LXRs: new therapeutic targets in atherosclerosis?Link is external (Link is external) (Link opens in new window) . Current opinion in pharmacology, 2003. Laffitte BA, Joseph SB, Chen M, Castrillo A, Repa J, Wilpitz D, Mangelsdorf D, Tontonoz P. The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions.Link is external (Link is external) (Link opens in new window) . Molecular and cellular biology, 2003. Castrillo A, Joseph SB, Marathe C, Mangelsdorf DJ, Tontonoz P. Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages.Link is external (Link is external) (Link opens in new window) . The Journal of biological chemistry, 2003. Joseph SB, Castrillo A, Laffitte BA, Mangelsdorf DJ, Tontonoz P. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors.Link is external (Link is external) (Link opens in new window) . Nature medicine, 2003. Tangirala RK, Bischoff ED, Joseph SB, Wagner BL, Walczak R, Laffitte BA, Daige CL, Thomas D, Heyman RA, Mangelsdorf DJ, Wang X, Lusis AJ, Tontonoz P, Schulman IG. Identification of macrophage liver X receptors as inhibitors of atherosclerosis.Link is external (Link is external) (Link opens in new window) . Proceedings of the National Academy of Sciences of the United States of America, 2002. Xu J, Xiao G, Trujillo C, Chang V, Blanco L, Joseph SB, Bassilian S, Saad MF, Tontonoz P, Lee WN, Kurland IJ. Peroxisome proliferator-activated receptor alpha (PPARalpha) influences substrate utilization for hepatic glucose production.Link is external (Link is external) (Link opens in new window) . The Journal of biological chemistry, 2002. Joseph SB, McKilligin E, Pei L, Watson MA, Collins AR, Laffitte BA, Chen M, Noh G, Goodman J, Hagger GN, Tran J, Tippin TK, Wang X, Lusis AJ, Hsueh WA, Law RE, Collins JL, Willson TM, Tontonoz P. Synthetic LXR ligand inhibits the development of atherosclerosis in mice.Link is external (Link is external) (Link opens in new window) . Proceedings of the National Academy of Sciences of the United States of America, 2002. Mak PA, Laffitte BA, Desrumaux C, Joseph SB, Curtiss LK, Mangelsdorf DJ, Tontonoz P, Edwards PA. Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.Link is external (Link is external) (Link opens in new window) . The Journal of biological chemistry, 2002. Laffitte BA, Tontonoz P. Orphan nuclear receptors find a home in the arterial wall.Link is external (Link is external) (Link opens in new window) . Current atherosclerosis reports, 2002. Walczak R, Tontonoz P. PPARadigms and PPARadoxes: expanding roles for PPARgamma in the control of lipid metabolism.Link is external (Link is external) (Link opens in new window) . Journal of lipid research, 2002. Joseph SB, Laffitte BA, Patel PH, Watson MA, Matsukuma KE, Walczak R, Collins JL, Osborne TF, Tontonoz P. Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors.Link is external (Link is external) (Link opens in new window) . The Journal of biological chemistry, 2002. Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.Link is external (Link is external) (Link opens in new window) . The Journal of biological chemistry, 2001. Laffitte BA, Joseph SB, Walczak R, Pei L, Wilpitz DC, Collins JL, Tontonoz P. Autoregulation of the human liver X receptor alpha promoter.Link is external (Link is external) (Link opens in new window) . Molecular and cellular biology, 2001. Singh Ahuja H, Liu S, Crombie DL, Boehm M, Leibowitz MD, Heyman RA, Depre C, Nagy L, Tontonoz P, Davies PJ. Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents.Link is external (Link is external) (Link opens in new window) . Molecular pharmacology, 2001. Laffitte BA, Repa JJ, Joseph SB, Wilpitz DC, Kast HR, Mangelsdorf DJ, Tontonoz P. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes.Link is external (Link is external) (Link opens in new window) . Proceedings of the National Academy of Sciences of the United States of America, 2001. Chawla A, Boisvert WA, Lee CH, Laffitte BA, Barak Y, Joseph SB, Liao D, Nagy L, Edwards PA, Curtiss LK, Evans RM, Tontonoz P. A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis.Link is external (Link is external) (Link opens in new window) . Molecular cell, 2001. Chawla A, Barak Y, Nagy L, Liao D, Tontonoz P, Evans RM. PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation.Link is external (Link is external) (Link opens in new window) . Nature medicine, 2001. Venkateswaran A, Laffitte BA, Joseph SB, Mak PA, Wilpitz DC, Edwards PA, Tontonoz P. Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha.Link is external (Link is external) (Link opens in new window) . Proceedings of the National Academy of Sciences of the United States of America, 2000. Lee H, Shi W, Tontonoz P, Wang S, Subbanagounder G, Hedrick CC, Hama S, Borromeo C, Evans RM, Berliner JA, Nagy L. Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells.Link is external (Link is external) (Link opens in new window) . Circulation research, 2000. Tontonoz P, Nagy L. Regulation of macrophage gene expression by peroxisome-proliferator-activated receptor gamma: implications for cardiovascular disease.Link is external (Link is external) (Link opens in new window) . Current opinion in lipidology, 1999. Devine JH, Eubank DW, Clouthier DE, Tontonoz P, Spiegelman BM, Hammer RE, Beale EG. Adipose expression of the phosphoenolpyruvate carboxykinase promoter requires peroxisome proliferator-activated receptor gamma and 9-cis-retinoic acid receptor binding to an adipocyte-specific enhancer in vivo.Link is external (Link is external) (Link opens in new window) . The Journal of biological chemistry, 1999. Saez E, Tontonoz P, Nelson MC, Alvarez JG, Ming UT, Baird SM, Thomazy VA, Evans RM. Activators of the nuclear receptor PPARgamma enhance colon polyp formation.Link is external (Link is external) (Link opens in new window) . Nature medicine, 1998. Nagy L, Tontonoz P, Alvarez JG, Chen H, Evans RM. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma.Link is external (Link is external) (Link opens in new window) . Cell, 1998. Tontonoz P, Nagy L, Alvarez JG, Thomazy VA, Evans RM. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL.Link is external (Link is external) (Link opens in new window) . Cell, 1998. Mueller E, Sarraf P, Tontonoz P, Evans RM, Martin KJ, Zhang M, Fletcher C, Singer S, Spiegelman BM. Terminal differentiation of human breast cancer through PPAR gamma.Link is external (Link is external) (Link opens in new window) . Molecular cell, 1998. Hollenberg AN, Susulic VS, Madura JP, Zhang B, Moller DE, Tontonoz P, Sarraf P, Spiegelman BM, Lowell BB. Functional antagonism between CCAAT/Enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter.Link is external (Link is external) (Link opens in new window) . The Journal of biological chemistry, 1997. Tontonoz P, Singer S, Forman BM, Sarraf P, Fletcher JA, Fletcher CD, Brun RP, Mueller E, Altiok S, Oppenheim H, Evans RM, Spiegelman BM. Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor.Link is external (Link is external) (Link opens in new window) . Proceedings of the National Academy of Sciences of the United States of America, 1997. Brun RP, Tontonoz P, Forman BM, Ellis R, Chen J, Evans RM, Spiegelman BM. Differential activation of adipogenesis by multiple PPAR isoforms.Link is external (Link is external) (Link opens in new window) . Genes & development, 1996. Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma.Link is external (Link is external) (Link opens in new window) . Cell, 1995. Hu E, Tontonoz P, Spiegelman BM. Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha.Link is external (Link is external) (Link opens in new window) . Proceedings of the National Academy of Sciences of the United States of America, 1995. Tontonoz P, Hu E, Spiegelman BM. Regulation of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor gamma.Link is external (Link is external) (Link opens in new window) . Current opinion in genetics & development, 1995. Tontonoz P, Hu E, Devine J, Beale EG, Spiegelman BM. PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene.Link is external (Link is external) (Link opens in new window) . Molecular and cellular biology, 1995. Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor.Link is external (Link is external) (Link opens in new window) . Cell, 1994. Tontonoz P, Graves RA, Budavari AI, Erdjument-Bromage H, Lui M, Hu E, Tempst P, Spiegelman BM. Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha.Link is external (Link is external) (Link opens in new window) . Nucleic acids research, 1994. Tontonoz P, Hu E, Graves RA, Budavari AI, Spiegelman BM. mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.Link is external (Link is external) (Link opens in new window) . Genes & development, 1994. Tontonoz P, Kim JB, Graves RA, Spiegelman BM. ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation.Link is external (Link is external) (Link opens in new window) . Molecular and cellular biology, 1993. Spiegelman BM, Choy L, Hotamisligil GS, Graves RA, Tontonoz P. Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes.Link is external (Link is external) (Link opens in new window) . The Journal of biological chemistry, 1993. Graves RA, Tontonoz P, Spiegelman BM. Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression.Link is external (Link is external) (Link opens in new window) . Molecular and cellular biology, 1992. Graves RA, Tontonoz P, Platt KA, Ross SR, Spiegelman BM. Identification of a fat cell enhancer: analysis of requirements for adipose tissue-specific gene expression.Link is external (Link is external) (Link opens in new window) . Journal of cellular biochemistry, 1992. Graves RA, Tontonoz P, Spiegelman BM. Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression.Link is external (Link is external) (Link opens in new window) . Molecular and cellular biology, 1992. Graves RA, Tontonoz P, Ross SR, Spiegelman BM. Identification of a potent adipocyte-specific enhancer: involvement of an NF-1-like factor.Link is external (Link is external) (Link opens in new window) . Genes & development, 1991.