Touma Lab

Publications

Highlights

Congratulations to our fellow Zubin Mehta for being nominated to present his outstanding work "Role of Alternative Splicing in Chamber-Specific Maturation of Neonatal Heart During Perinatal Circulatory Transition" at the 97th Perinatal and Developmental Medicine Symposium June 9-11, 2021.

Neonatal Heart Maturation SuperSeries Contributed to the Gene Expression Omnibus repository(Link is external) (Link opens in new window)

Editorial Commentary: Scot J. Matkovich. Of Caps and Gaps, Postnatal Hearts, Elusive Facts, and lncs. Circulation: Cardiovascular Genetics: 2016; 9:389-391. PMID: 27756779.
DOI: 10.1161/CIRCGENETICS.116.001608(Link is external)

Decoding the Long Noncoding RNA During Cardiac Maturation: A Roadmap for Functional Discovery(Link is external) (Link opens in new window).

JovE: Fetal Heart Echocardiography. https://www.jove.com/video/57210/fetal-mouse-cardiovascular-imaging-using-high-frequency-ultrasound(Link is external) (Link opens in new window).

Visit our NCBI public Bibliography(Link is external) (Link opens in new window)

  1. Recessive ciliopathy mutations in primary endocardial fibroelastosis: a rare neonatal cardiomyopathy in a case of Alstrom syndrome.(Link is external) (Link opens in new window) Zhao Y, Wang LK, Eskin A, Kang X, Fajardo VM, Mehta Z, Pineles S, Schmidt RJ, Nagiel A, Satou G, Garg M, Federman M, Reardon LC, Lee SL, Biniwale R, Grody WW, Halnon N, Khanlou N, Quintero-Rivera F, Alejos JC, Nakano A, Fishbein GA, Van Arsdell GS, Nelson SF, Touma M. J Mol Med (Berl). 2021 Nov;99(11):1623-1638. doi: 10.1007/s00109-021-02112-z. PMID: 34387706
  2. Gene-environment regulation of chamber-specific maturation during hypoxemic perinatal circulatory transition.(Link is external) (Link opens in new window) Zhao Y, Kang X, Barsegian A, He J, Guzman A, Lau RP, Biniwale R, Wadhra M, Reemtsen B, Garg M, Halnon N, Quintero-Rivera F, Grody WW; UCLA Congenital Heart Defects BioCore Faculty, Van Arsdell G, Nelson SF, Touma M. J Mol Med (Berl). 2020 Jul;98(7):1009-1020. doi: 10.1007/s00109-020-01933-8. PMID: 32533200.
  3. COVID-19: molecular diagnostics overview.(Link is external) (Link opens in new window) Touma M. J Mol Med (Berl). 2020 Jul;98(7):947-954. doi: 10.1007/s00109-020-01931-w. 2020. PMID: 32535768.
  4. p38 mitogen-activated protein kinase regulates chamber specific perinatal growth in heart.(Link is external) (Link opens in new window) Yokota T, Li J, Huang J, Xiong Z, Zhang Q, Chan TW, Ding Y, Rau CD, Sung K, Ren S, Kulkarni RP, Hsiai T, Xiao X, Touma M, Minamisawa S, Wang Y. J Clin Invest. 2020 Jun 23:135859. doi: 10.1172/JCI135859. PMID: 32573492.
  5. Echocardiographic markers of pulmonary hemodynamics and right ventricular hypertrophy in rat models of pulmonary hypertension.(Link is external) (Link opens in new window) Spyropoulos F, Vitali SH, Touma M, Rose CD, Petty CR, Levy P, Kourembanas S, Christou H. Pulm Circ. 2020 May 29;10(2):2045894020910976. doi: 10.1177/2045894020910976. PMID: 32537128.
  6. Ppp1r1b-lncRNA inhibits PRC2 at myogenic regulatory genes to promote cardiac and skeletal muscle development in mouse and human.(Link is external) (Link opens in new window) Kang X, Zhao Y, Van Arsdell G, Nelson SF, Touma M.  RNA. 2020 Apr;26(4):481-491. doi: 10.1261/rna.073692.119. PMID: 31953255.
  7. Genome regulation by long noncoding RNAs in neonatal heart maturation and congenital heart defects. Touma M. Journal of Cellular and Molecular Medicine. January 2020. DOI: 10.15761/JCMM.1000131
  8. Gene-environment regulatory circuits of right ventricular pathology in tetralogy of fallot.(Link is external) (Link opens in new window) Zhao Y, Kang X, Gao F, Guzman A, Lau RP, Biniwale R, Wadehra M, Reemtsen B, Garg M, Halnon N, Quintero-Rivera F, Van Arsdell G, Coppola G, Nelson SF, Touma M; UCLA Congenital Heart Defects BioCore Faculty. J Mol Med (Berl). 2019 Dec;97(12):1711-1722. doi: 10.1007/s00109-019-01857-y. PMID: 31834445.
  9. Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System.(Link is external) (Link opens in new window) Touma M. J Vis Exp. 2018 May 5;(135):57210. doi: 10.3791/57210. PMID: 29781990.
  10. Wnt11 regulates cardiac chamber development and disease during perinatal maturation.(Link is external) (Link opens in new window) Touma M, Kang X, Gao F, Zhao Y, Cass AA, Biniwale R, Xiao X, Eghbali M, Coppola G, Reemtsen B, Wang Y. JCI Insight. 2017 Sep 7;2(17):e94904. doi: 10.1172/jci.insight.94904. eCollection 2017 Sep 7.JCI Insight. 2017. PMID: 28878122.
  11. A Path to Implement Precision Child Health Cardiovascular Medicine.(Link is external) (Link opens in new window) Touma M, Reemtsen B, Halnon N, Alejos J, Finn JP, Nelson SF, Wang Y. Front Cardiovasc Med. 2017 Jun 1;4:36. doi: 10.3389/fcvm.2017.00036. PMID: 28620608.
  12. Decoding the Long Noncoding RNA During Cardiac Maturation: A Roadmap for Functional Discovery.(Link is external) (Link opens in new window) Touma M, Kang X, Zhao Y, Cass AA, Gao F, Biniwale R, Coppola G, Xiao X, Reemtsen B, Wang Y. Circ Cardiovasc Genet. 2016 Oct;9(5):395-407. doi: 10.1161/CIRCGENETICS.115.001363. PMID: 27591185.
  13. Maternal Calorie Restriction Causing Uteroplacental Insufficiency Differentially Affects Mammalian Placental Glucose and Leucine Transport Molecular Mechanisms.(Link is external) (Link opens in new window) Ganguly A, Touma M, Thamotharan S, De Vivo DC, Devaskar SU. 2016 Oct; 157(10):4041-4054. doi: 10.1210/en.2016-1259. PMID: 27494059.
  14. Hematopoietic progenitors are required for proper development of coronary vasculature.(Link is external) (Link opens in new window) Lluri G, Huang V, Touma M, Liu X, Harmon AW, Nakano A. J Mol Cell Cardiol. 2015 Sep;86:199-207. doi: 10.1016/j.yjmcc.2015.07.021. PMID: 26241844.
  15. Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells.(Link is external) (Link opens in new window) Briot A, Jaroszewicz A, Warren CM, Lu J, Touma M, Rudat C, Hofmann JJ, Airik R, Weinmaster G, Lyons K, Wang Y, Kispert A, Pellegrini M, Iruela-Arispe ML. Dev Cell. 2014 Dec 22;31(6):707-21. doi: 10.1016/j.devcel.2014.11.023. Dev Cell. 2014. PMID: 25535917.
  16. Decoding the noncoding transcripts in human heart failure.(Link is external) (Link opens in new window) Xiao XG, Touma M, Wang Y. 2014 Mar 4;129(9):958-60. doi: 10.1161/CIRCULATIONAHA.114.007548. PMID: 24429689.
  17. Nkx2-5 suppresses the proliferation of atrial myocytes and conduction system.(Link is external) (Link opens in new window) Nakashima Y, Yanez DA, Touma M, Nakano H, Jaroszewicz A, Jordan MC, Pellegrini M, Roos KP, Nakano A. Circ Res. 2014 Mar 28;114(7):1103-13. doi: 10.1161/CIRCRESAHA.114.303219. PMID: 24563458.
  18. Whole genome sequencing identifies SCN2A mutation in monozygotic twins with Ohtahara syndrome and unique neuropathologic findings.(Link is external) (Link opens in new window) Touma M, Joshi M, Connolly MC, Grant PE, Hansen AR, Khwaja O, Berry GT, Kinney HC, Poduri A, Agrawal PB.  Epilepcia 2013 May; 54(5):e81-5. doi: 10.1111/epi.12137. PMID: 23550958.
  19. Improved pulmonary vascular reactivity and decreased hypertrophic remodeling during nonhypercapnic acidosis in experimental pulmonary hypertension.(Link is external) (Link opens in new window) Christou H, Reslan OM, Mam V, Tanbe AF, Vitali SH, Touma M, Arons E, Mitsialis SA, Kourembanas S, Khalil RA. Am J Physiol Lung Cell Mol Physiol. 2012 May 1;302(9):L875-90. doi: 10.1152/ajplung.00293.2011. 2012. PMID: 22287610.