A selected list of publications:

1)  Ishihara M, Hu J, Zhang X, Choi Y, Wong A, Cano-Ruiz C, Zhao R, Tan P, Tso JL, Wu L.  Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane.  J Vis Exp. 2020 Feb 8;(156). doi: 10.3791/60314. PMID: 32091005

2)  Sharrow AC, Ishihara M, Hu J, Kim IH, Wu L.  Using the Chicken Chorioallantoic Membrane In Vivo Model to Study Gynecological and Urological Cancers.  J Vis Exp. 2020 Jan 28;(155):10.3791/60651. doi: 10.3791/60651. PMID: 32065133

3)   Yan L, Ding B, Liu H, Zhang Y, Zeng J, Hu J, Yao W, Yu G, An R, Chen Z, Ye Z, Xing J, Xiao K, Wu L, Xu H.  Inhibition of SMYD2 suppresses tumor progression by down-regulating microRNA-125b and attenuates multi-drug resistance in renal cell carcinoma.  Theranostics. 2019 Oct 22;9(26):8377-8391. doi: 10.7150/thno.37628. eCollection 2019. PMID: 31754403

4)  Ishihara M, Hu J, Wong A, Cano-Ruiz C, Wu L.  Mouse- and patient-derived CAM xenografts for studying metastatic renal cell carcinoma.  Enzymes. 2019;46:59-80. doi: 10.1016/bs.enz.2019.08.009. Epub 2019 Oct 18. PMID: 31727277

5)  Hu J, Ishihara M, Chin AI, Wu L.  Establishment of xenografts of urological cancers on chicken chorioallantoic membrane (CAM) to study metastasis.   Precis Clin Med. 2019 Sep;2(3):140-151. doi: 10.1093/pcmedi/pbz018. Epub 2019 Oct 1. PMID: 31598385

6)   Hu J, Guan W, Yan L, Ye Z, Wu L, Xu H.  Cancer Stem Cell Marker Endoglin (CD105) Induces Epithelial Mesenchymal Transition (EMT) but Not Metastasis in Clear Cell Renal Cell Carcinoma.  Stem Cells Int. 2019 Mar 19;2019:9060152. doi: 10.1155/2019/9060152. eCollection 2019. PMID: 31015843  

7)  Guan W, Hu J, Yang L, Tan P, Tang Z, West BL, Bollag G, Xu H, Wu L.  Inhibition of TAMs improves the response to docetaxel in castration-resistant prostate cancer.  Endocr Relat Cancer. 2019 Jan 1;26(1):131-140. doi: 10.1530/ERC-18-0284.PMID: 30400004

8)  Saylor J, Ma Z, Goodridge HS, Huang F, Cress AE, Pandol SJ, Shiao SL, Vidal AC, Wu L, Nickols NG, Gertych A, Knudsen BS.  Spatial Mapping of Myeloid Cells and Macrophages by Multiplexed Tissue Staining.  Front Immunol. 2018 Dec 14;9:2925. doi: 10.3389/fimmu.2018.02925. eCollection 2018. PMID: 30619287

9)  Hu J, Schokrpur S, Archang M, Hermann K, Sharrow AC, Khanna P, Novak J, Signoretti S, Bhatt RS, Knudsen BS, Xu H, Wu L.  A Non-integrating Lentiviral Approach Overcomes Cas9-Induced Immune Rejection to Establish an Immunocompetent Metastatic Renal Cancer Model.  Mol Ther Methods Clin Dev. 2018 Feb 23;9:203-210. doi: 10.1016/j.omtm.2018.02.009. eCollection 2018 Jun 15. PMID: 29766028

10)  Li H, Wang Z, Xiao W, Yan L, Guan W, Hu Z, Wu L, Huang Q, Wang J, Xu H, Zhang X, Ye Z. Androgen-receptor splice variant-7-positive prostate cancer: a novel molecular subtype with markedly worse androgen-deprivation therapy outcomes in newly diagnosed patients.  Mod Pathol. 2018 Jan;31(1):198-208. doi: 10.1038/modpathol.2017.74. Epub 2017 Oct 27. PMID: 29076496

11)  Dai X, Wu L, Sun R, Zhou ZH.   Atomic Structures of Minor Proteins VI and VII in Human Adenovirus.    J Virol. 2017 Nov 30;91(24):e00850-17. doi: 10.1128/JVI.00850-17. Print 2017 Dec 15. PMID: 28978703 

12)  Hu J, Guan W, Liu P, Dai J, Tang K, Xiao H, Qian Y, Sharrow AC, Ye Z, Wu L, Xu H.  Endoglin Is Essential for the Maintenance of Self-Renewal and Chemoresistance in Renal Cancer Stem Cells.  Stem Cell Reports. 2017 Aug 8;9(2):464-477. doi: 10.1016/j.stemcr.2017.07.009. PMID: 28793246

13)  Chen K, Xiao H, Zeng J, Yu G, Zhou H, Huang C, Yao W, Xiao W, Hu J, Guan W, Wu L, Huang J, Huang Q, Xu H, Ye Z.  Alternative Splicing of EZH2 pre-mRNA by SF3B3 Contributes to the Tumorigenic Potential of Renal Cancer.  Clin Cancer Res. 2017 Jul 1;23(13):3428-3441. doi: 10.1158/1078-0432.CCR-16-2020. Epub 2016 Nov 22. PMID: 27879367  

14)  Jain P, Neveu B, Velot L, Wu L, Fradet Y, Pouliot F.  Corrigendum: Bioluminescence Microscopy as a Method to Measure Single Cell Androgen Receptor Activity Heterogeneous Responses to Antiandrogens.   Sci Rep. 2016 Nov 21;6:37381. doi: 10.1038/srep37381. PMID: 27869232

15)  Jain P, Neveu B, Velot L, Wu L, Fradet Y, Pouliot F.  Bioluminescence Microscopy as a Method to Measure Single Cell Androgen Receptor Activity Heterogeneous Responses to Antiandrogens.  Sci Rep. 2016 Sep 28;6:33968. doi: 10.1038/srep33968. PMID: 27678181

16)  Vega-Crespo A, Truong B, Hermann KJ, Awe JP, Chang KM, Lee PC, Schoenberg BE, Wu L, Byrne JA, Lipshutz GS.  Investigating the functionality of an OCT4-short response element in human induced pluripotent stem cells.  Mol Ther Methods Clin Dev. 2016 Jul 20;3:16050. doi: 10.1038/mtm.2016.50. eCollection 2016. PMID: 27500178  

17)  Schokrpur S, Hu J, Moughon DL, Liu P, Lin LC, Hermann K, Mangul S, Guan W, Pellegrini M, Xu H, Wu L.  CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma.  Sci Rep. 2016 Jun 30;6:29032. doi: 10.1038/srep29032. PMID: 27358011

18)  Liang P, Henning SM, Schokrpur S, Wu L, Doan N, Said J, Grogan T, Elashoff D, Cohen P, Aronson WJ.  Effect of Dietary Omega-3 Fatty Acids on Tumor-Associated Macrophages and Prostate Cancer Progression.  Prostate. 2016 Oct;76(14):1293-302. doi: 10.1002/pros.23218. Epub 2016 Jun 24. PMID: 27338236

19)  Hou S, Choi JS, Garcia MA, Xing Y, Chen KJ, Chen YM, Jiang ZK, Ro T, Wu L, Stout DB, Tomlinson JS, Wang H, Chen K, Tseng HR, Lin WY.   Pretargeted Positron Emission Tomography Imaging That Employs Supramolecular Nanoparticles with in Vivo Bioorthogonal Chemistry.  ACS Nano. 2016 Jan 6;10(1):1417-24. doi: 10.1021/acsnano.5b06860. Epub 2016 Jan 12. PMID:26731174

20)  Neveu B, Jain P, Têtu B, Wu L, Fradet Y, Pouliot F.  A PCA3 gene-based transcriptional amplification system targeting primary prostate cancer.  Oncotarget. 2016 Jan 12;7(2):1300-10. doi: 10.18632/oncotarget.6360. PMID: 26594800

21)  Moughon DL, He H, Schokrpur S, Jiang ZK, Yaqoob M, David J, Lin C, Iruela-Arispe ML, Dorigo O, Wu L.  Macrophage Blockade Using CSF1R Inhibitors Reverses the Vascular Leakage Underlying Malignant Ascites in Late-Stage Epithelial Ovarian Cancer.  Cancer Res. 2015 Nov 15;75(22):4742-52. doi: 10.1158/0008-5472.CAN-14-3373. Epub 2015 Oct 15. PMID: 26471360

22) Escamilla J, Schokrpur S, Liu C, Priceman SJ, Moughon D, Jiang Z, Pouliot F, Magyar C, Sung JL, Xu J, Deng G, West BL, Bollag G, Fradet Y, Lacombe L, Jung ME, Huang J, Wu L.   CSF1 receptor targeting in prostate cancer reverses macrophage-mediated resistance to androgen blockade therapy.  Cancer Res. 2015 Mar 15;75(6):950-62. doi: 10.1158/0008-5472.CAN-14-0992. Epub 2015 Mar 3. PMID: 25736687

23)  Garcia AJ, Ruscetti M, Arenzana TL, Tran LM, Bianci-Frias D, Sybert E, Priceman SJ, Wu L, Nelson PS, Smale ST, Wu H.  Pten null prostate epithelium promotes localized myeloid-derived suppressor cell expansion and immune suppression during tumor initiation and progression.  Mol Cell Biol. 2014 Jun;34(11):2017-28. doi: 10.1128/MCB.00090-14. Epub 2014 Mar 24.PMID: 24662052

24)  Mok S, Koya RC, Tsui C, Xu J, Robert L, Wu L, Graeber T, West BL, Bollag G, Ribas A. Inhibition of CSF-1 receptor improves the antitumor efficacy of adoptive cell transfer immunotherapy.  Cancer Res. 2014 Jan 1;74(1):153-161. doi: 10.1158/0008-5472.CAN-13-1816. Epub 2013 Nov 18. PMID: 24247719

25)  Jiang ZK, Johnson M, Moughon DL, Kuo J, Sato M, Wu L.  Rapamycin enhances adenovirus-mediated cancer imaging and therapy in pre-immunized murine hosts.  PLoS One. 2013 Sep 2;8(9):e73650. doi: 10.1371/journal.pone.0073650. eCollection 2013. PMID: 24023896

26)  Xu J, Escamilla J, Mok S, David J, Priceman S, West B, Bollag G, McBride W, Wu L.  CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer.  Cancer Res. 2013 May 1;73(9):2782-94. doi: 10.1158/0008-5472.CAN-12-3981. Epub 2013 Feb 15. PMID: 23418320

27)  Pouliot F, Sato M, Jiang ZK, Huyn S, Karanikolas BD, Wu L.  A molecular imaging system based on both transcriptional and genomic amplification to detect prostate cancer cells in vivo.  Mol Ther. 2013 Mar;21(3):554-60. doi: 10.1038/mt.2012.259. Epub 2012 Dec 18. PMID: 23247102

28)  Jiang ZK, Koh SB, Sato M, Atanasov IC, Johnson M, Zhou ZH, Deming TJ, Wu L.  Engineering polypeptide coatings to augment gene transduction and in vivo stability of adenoviruses.  J   Control Release. 2013 Feb 28;166(1):75-85. doi: 10.1016/j.jconrel.2012.10.023. Epub 2012 Dec 16. PMID: 23247040

29)  Jiang ZK, Sato M, Wu L. Chapter five--The development of transcription-regulated adenoviral vectors with high cancer-selective imaging capabilities.  Adv Cancer Res. 2012;115:115-46. doi: 10.1016/B978-0-12-398342-8.00005-7. PMID: 23021244

29)  He H, Xu J, Warren CM, Duan D, Li X, Wu L, Iruela-Arispe ML.  Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages.  Blood. 2012 Oct 11;120(15):3152-62. doi: 10.1182/blood-2012-04-422758. Epub 2012 Aug 23. PMID: 22919031

30)  Jiang ZK, Sato M, Wei LH, Kao C, Wu L.    Androgen-independent molecular imaging vectors to detect castration-resistant and metastatic prostate cancer.  Cancer Res. 2011 Oct 1;71(19):6250-60. doi: 10.1158/0008-5472.CAN-11-1520. Epub 2011 Sep 20. PMID: 21933883

31)  Pouliot F, Karanikolas BD, Johnson M, Sato M, Priceman SJ, Stout D, Sohn J, Satyamurthy N, deKernion JB, Wu L.  In vivo imaging of intraprostatic-specific gene transcription by PET.  J Nucl Med. 2011 May;52(5):784-91. doi: 10.2967/jnumed.110.084582. Epub 2011 Apr 15. PMID: 21498525

32)  Chen L, Hann B, Wu L. Experimental models to study lymphatic and blood vascular metastasis.  J Surg Oncol. 2011 May 1;103(6):475-83. doi: 10.1002/jso.21794. PMID: 21480239

33)  Chen KJ, Wolahan SM, Wang H, Hsu CH, Chang HW, Durazo A, Hwang LP, Garcia MA, Jiang ZK, Wu L, Lin YY, Tseng HR.  A small MRI contrast agent library of gadolinium(III)-encapsulated supramolecular nanoparticles for improved relaxivity and sensitivity.  Biomaterials. 2011 Mar;32(8):2160-5. doi: 10.1016/j.biomaterials.2010.11.043. Epub 2010 Dec 16. PMID: 21167594

34)  Liu H, Wu L, Zhou ZH.  Model of the trimeric fiber and its interactions with the pentameric penton base of human adenovirus by cryo-electron microscopy.  J Mol Biol. 2011 Mar 11;406(5):764-74. doi: 10.1016/j.jmb.2010.11.043. Epub 2010 Dec 10. PMID: 21146538

35)  Kwon OJ, Kim PH, Huyn S, Wu L, Kim M, Yun CO.  A hypoxia- and {alpha}-fetoprotein-dependent oncolytic adenovirus exhibits specific killing of hepatocellular carcinomas. Clin Cancer Res. 2010 Dec 15;16(24):6071-82. doi: 10.1158/1078-0432.CCR-10-0664. PMID: 21169258

36)  Pouliot F, Wu L.  Cardiac glycosides may affect prostate specific antigen levels.  J Urol. 2010 Nov;184(5):1831-2. doi: 10.1016/j.juro.2010.08.052. Epub 2010 Sep 17. PMID: 20846675  

37)   Sloan EK, Priceman SJ, Cox BF, Yu S, Pimentel MA, Tangkanangnukul V, Arevalo JM, Morizono K, Karanikolas BD, Wu L, Sood AK, Cole SW.  The sympathetic nervous system induces a metastatic switch in primary breast cancer.  Cancer Res. 2010 Sep 15;70(18):7042-52. doi: 10.1158/0008-5472.CAN-10-0522. Epub 2010 Sep 7. PMID: 20823155

38)  Liu H, Jin L, Koh SB, Atanasov I, Schein S, Wu L, Zhou ZH.   Atomic structure of human adenovirus by cryo-EM reveals interactions among protein networks.  Science. 2010 Aug 27;329(5995):1038-43. doi: 10.1126/science.1187433. PMID: 20798312

39)  Imaizumi S, Grijalva V, Priceman S, Wu L, Su F, Farias-Eisner R, Hama S, Navab M, Fogelman AM, Reddy ST.   Mitogen-activated protein kinase phosphatase-1 deficiency decreases atherosclerosis in apolipoprotein E null mice by reducing monocyte chemoattractant protein-1 levels.  Mol Genet Metab. 2010 Sep;101(1):66-75. doi: 10.1016/j.ymgme.2010.05.009. Epub 2010 Jun 9. PMID: 20619710

40)  Karanikolas BD, Figueiredo ML, Wu L.  Comprehensive evaluation of the role of EZH2 in the growth, invasion, and aggression of a panel of prostate cancer cell lines.  Prostate. 2010 May 1;70(6):675-88. doi: 10.1002/pros.21112. PMID: 20087897

41)  Priceman SJ, Sung JL, Shaposhnik Z, Burton JB, Torres-Collado AX, Moughon DL, Johnson M, Lusis AJ, Cohen DA, Iruela-Arispe ML, Wu L.  Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy.  Blood. 2010 Feb 18;115(7):1461-71. doi: 10.1182/blood-2009-08-237412. Epub 2009 Dec 11.PMID: 20008303

42)  Yan M, Du J, Gu Z, Liang M, Hu Y, Zhang W, Priceman S, Wu L, Zhou ZH, Liu Z, Segura T, Tang Y, Lu Y.  A novel intracellular protein delivery platform based on single-protein nanocapsules.  Nat Nanotechnol. 2010 Jan;5(1):48-53. doi: 10.1038/nnano.2009.341. Epub 2009 Nov 22. PMID: 19935648

43)   Narasimha AJ, Watanabe J, Ishikawa TO, Priceman SJ, Wu L, Herschman HR, Reddy ST.   Absence of myeloid COX-2 attenuates acute inflammation but does not influence development of atherosclerosis in apolipoprotein E null mice.  Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):260-8. doi: 10.1161/ATVBAHA.109.198762. Epub 2009 Nov 19. PMID: 19926832