Research Updates

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Latest Research

UCLA Endocrine Surgery is committed to ongoing research in a quest to develop new treatments and cures for all for patients with conditions of the thyroid, parathyroid, and adrenal glands.


End-organ Effects of Primary Hyperparathyroidism: A population-based Study
Surgery for Primary Hyperparathyroidism: Adherence to Consensus Guidelines in an Academic Health System
Visual Abstract

Background: Patients with primary hyperparathyroidism are at risk for skeletal and renal end-organ damage. Methods: We studied patients with biochemically confirmed primary hyperparathyroidism from 1995–2014 and quantified the frequency of osteoporosis, nephrolithiasis, hypercalciuria, and decrease in renal function.
Link to Manuscript >


Gene Expression Classifier vs Targeted Next-Generation Sequencing in the Management of Indeterminate Thyroid Nodules
Gene Expression Classifier vs Targeted Next-Generation Sequencing
Visual Abstract

Objective: Compare the diagnostic performance of Afirma Gene Expression Classifier (GEC) with that of ThyroSeq v2 next-generation sequencing assay.
Link to Manuscript >


Surgery for Primary Hyperparathyroidism: Adherence to Consensus Guidelines in an Academic Health System
Surgery for Primary Hyperparathyroidism: Adherence to Consensus Guidelines in an Academic Health System
Visual Abstract

Objective: To determine the extent to which consensus guidelines for surgery in patients with primary hyperparathyroidism (PHPT) are followed within an academic health system.
Link to Manuscript >


Factors Associated With Discordance Between Preoperative Parathyroid
Visual Abstract
Factors Associated With Discordance Between Preoperative Parathyroid 4-Dimensional Computed Tomographic Scans and Intraoperative Findings During Parathyroidectomy

Question: What factors contribute to discordance between preoperative parathyroid 4-dimensional computed tomographic scans and intraoperative findings?
Link to Manuscript >


Sustained Growth of a University-Based Endocrine Surgery Program
Visual Abstract
Sustained Growth of a University-Based Endocrine Surgery Program Over 10 Years

Background: Endocrine surgery continues to mature as a subspecialty field. We describe the clinical performance of an academic endocrine surgery program (ESP) over its first 10 years.
Link to Manuscript >


The Relationship of Parathyroidectomy and Bisphosphonates With Fracture Risk in Primary Hyperparathyroidism
Visual Abstract
The Relationship of Parathyroidectomy and Bisphosphonates With Fracture Risk in Primary Hyperparathyroidism: An Observational Study

Objective: To measure the relationship of parathyroidectomy and bisphosphonates with skeletal outcomes in patients with PHPT.
Link to Manuscript >


Decreasing use of radioactive iodine for low risk thyroid cancer in California
Visual Abstract
Decreasing use of radioactive iodine for low risk thyroid cancer in California, 1999-2015

Context: Routine radioactive iodine (RAI) ablation for low-risk differentiated thyroid cancer (DTC) is not supported by current practice guidelines. Objective: To assess recent stage-specific trends in utilization of RAI ablation.
Link to Manuscript >


Single-incision retroperitoneoscopic adrenalectomy
Visual Abstract
Single-incision retroperitoneoscopic adrenalectomy: a North American experience

Background: Endoscopic adrenalectomy is currently performed using multiple ports placed either transabdominally or retroperitoneally. We report our initial experience with single-incision retroperitoneoscopic adrenalectomy (SIRA).
Link to Manuscript >


Risk Factors Associated With Reoperation and Disease-Specific Mortality in Patients With Medullary Thyroid Carcinoma
Visual Abstract
Risk Factors Associated With Reoperation and Disease-Specific Mortality in Patients With Medullary Thyroid Carcinoma

Question: What is the association of initial neck dissection with the need for reoperation in medullary thyroid carcinoma?
Link to Manuscript >


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