Beth Karlan, MD

Dr. Beth Karlan is a gynecologic oncologist and clinician-scientist with long-standing interests in hereditary cancers and molecular drivers of ovarian cancer. Recognizing the heterogeneity of ovarian cancer, she seeks to identify subtyped-specific biomarkers for early detection, prognostication and personalized therapies. She is also active in studying inherited cancer risks due to genes like BRCA to better understand ovarian cancer etiology, improve prevention strategies and identify novel targets for prevention and treatment.

Kotsopoulos J, Karlan BY, Gronwald J, Hall E, Moller P, Tung N, Zakalik D, Foulkes WD, R sen B, Neuhausen SL, Sun P, Lubinski J, Narod SA: Long-term outcomes following a diagnosis of ovarian cancer at the time of preventive oophorectomy among BRCA1 and BRCA2 mutation carriers. Int J Gynecol Cancer. 2020 June;30(6):825 830. Doi: 10.1136/ijgc-2019-001141. PMID: 3235479

Morgan KM, Hamilton JG, Symecko H, Kamara D, Jenkins C, Lester J, Spielman K, Pace LE, Gabriel C, Levin JD, Tejada PR, Braswell A, Marcell V, Wildman T, Devolder B, Baum RC, Block JN, Fesko Y, Boehler K, Howell V, Heitler J, Robson ME, Nathanson KL, Tung N, Karlan BY, Domchek SM, Garber JE, Offit K: Targeted BRCA1/2 population screening among Ashkenazi Jewish individuals using a web-enabled medical model: An observational cohort study. Genet Med. 2022 Mar;24(3):564-575. Doi: 10.1016/j.gim.2021.10.016. Epub 2021 Dec 2. PMID: 34906490.

Yucer N, Holzapfel M, Jenkins Vogel T, Lenaeus L, Ornelas L, Laury A, Sareen D, BarrettR, KarlanBY, Svendsen CN: Directed differentiation of human induced pluripotent stem cells into fallopian tube epithelium. Sci Rep. 2017 Sep 6;7(1):10741. doi: 10.1038/s41598-017-05519-2. PMIDL 28878359

Yucer N, Ahdoot R, Workman MJ, Yucer Laperle AH, Recouvreux MS, Kurowski K, Naboulsi DJ, Liang V, Qu Y, Plummer JT, Gayther SA, Orsulic S, Karlan BY, Svendsen CN: Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early stage carcinogenesis. Cell Rep. 2021 Dec 28;37(13):110146. doi: 10.1016/j.celrep.2021.110146. PMID: 34965417

Gertych A, Walts AE, Cheng K, Liu M, John J, Lester J, Karlan BY, Orsulic S: Dynamic changes in the extracellular matrix in primary, metastatic, and recurrent ovarian cancers. Cells. 2022 Nov 25;11(23):3769. doi: 10.3390/cells11233769. PMID 36497028