Lydia Daboussi, PhD

The Daboussi Laboratory focuses on elucidating how cytoplasmic-to-nuclear signaling regulates the transdifferentiation, proliferation, and identity of glial repair cells in the peripheral nervous system. The lab employs a multifaceted approach that integrates pharmacological techniques, primary cell cultures, and mouse genetic models to pinpoint the crucial signals, transduction pathways and transcription factors governing these processes. The primary goaI of the lab is to identify the signaIs, and signaling cascades that regulate transcription factor activity during regeneration. Disruptions in the normal regeneration process can lead to over-proliferation of progenitor-like Schwann cell populations and contribute to nerve-specific cancers. Thus, understanding the transcriptional regulation of neural repair is essential for comprehending how glial cells facilitate peripheral nerve regeneration following injury, during chronic disease, and throughout aging.

Daboussi L, Costaguta G, Gullo M, Jasinski N, Pessino V, O'Leary B, Lettieri K, Driscoll S, Pfaff SL. Mitf is a Schwann cell sensor of axonal integrity that drives nerve repair. Cell Rep. 2023 11 28; 42(11):113282. 

Costaguta G, Payne GS, Daboussi L. Live Cell Imaging of Yeast Golgi Dynamics. Methods Mol Biol. 2023; 2557:3-15. view on PubMed Daboussi L, Costaguta G, Ghukasyan R, Payne GS. Conserved role for Gga proteins in phosphatidylinositol 4-kinase localization to the trans-Golgi network. Proc Natl Acad Sci U S A. 2017 03 28; 114(13):3433-3438. 

Gorynia S, Lorenz TC, Costaguta G, Daboussi L, Cascio D, Payne GS. Yeast Irc6p is a novel type of conserved clathrin coat accessory factor related to small G proteins. Mol Biol Cell. 2012 Nov; 23(22):4416-29. 

Daboussi L, Costaguta G, Payne GS. Phosphoinositide-mediated clathrin adaptor progression at the trans-Golgi network. Nat Cell Biol. 2012 Feb 19; 14(3):239-48.