Epigenomics, RNA and Gene Regulation

Overview

The Epigenomics, RNA & Gene Regulation (ERGR) research program promotes UCLA's outstanding gene regulation researchers to apply their expertise to the cancer problem. It is expected that ERGR insights into the regulatory mechanisms governing the basic molecular and cellular biology of cancer will reveal cancer vulnerabilities that can be targeted by novel strategies to improve cancer diagnosis and treatment. ERGR research program investigators employ diverse model systems to elucidate fundamental mechanisms of gene regulation, from chromatin and transcription to RNA biology, and their alterations in cancer. Program studies extend to regulation of physiological processes that contribute to cancer pathogenesis including cell fate changes, inflammation and metabolism.

The ERGR research program leads in development of new technologies and methodologies including cutting-edge informatics to meet the demands of today's high-throughput experimental tools and provide expertise to researchers in other UCLA Health Jonsson Comprehensive Cancer Center research programs. In addition to focusing on mechanisms underlying fundamental epigenomics and gene regulatory processes, the ERGR research program strives to translate their discoveries to pre-clinical and clinical applications. The ERGR membership is drawn from three UCLA Schools and affiliate institution Caltech, representing a wide variety of departments, and thus serves as the intellectual home for Cancer Center researchers with interests broadly related to gene regulation.

The ERGR research program consciously cultivates a collegial environment and many opportunities for exchange of ideas, research findings and scientific discussions among the faculty, senior research fellows, postdocs, students, and clinicians. Such interactions lead to establishment of valuable and fruitful collaborations that raise the quality of ERGR research program science all while inspiring interest in and applications to cancer-related problems. To prepare for future challenges, the ERGR research program anticipates, identifies and recruits new young and established researchers with great potential or outstanding record of accomplishment whose expertise align with program goals and complement ongoing efforts by program faculty.

Specific Aims

The ERGR Research Program primary objective is to pioneer breakthroughs in the understanding of mechanisms of gene regulation and cell function, define how these are altered in cancer, and to provide validated pathways for detecting and targeting cancer.

To achieve its objective, the ERGR research program has three specific aims to:

1. To elucidate fundamental gene regulation and epigenetic mechanisms that are altered in cancer
2. To decipher the molecular regulation of cellular states and physiological processes that impact cancer pathogenesis
3. To connect alterations in cancer genomics and gene regulation to translational applications in cancer detection and treatment

Meetings and Seminars

The Epigenomics, RNA and Gene Regulation Program participates in a variety of recurring seminars, meetings and events. Please see Upcoming Events below for a complete list of all currently scheduled ERGR-related activities.

• The ERGR Journal Club hosts different ERGR labs who present exciting published papers. Meets every Friday at noon, with lunch served. For more information on attending or presenting a paper, please contact Kathrin Plath via email.
• Riboforum is a forum for ERGR labs with interests in RNA biology and features data presentations from ERGR labs and other interested laboratories. Meets the second Wednesday of every month at 3:30pm in Boyer 159. For more information, please contact Dr. Elsie Jacobson via email.
• The ERGR data club hosts different ERGR labs to present their work. Please contact Kathrin Plath via email.
• Co-sponsors the monthly Hematology Research Meeting “Blood Group” with the CSCB Research Program. Please contact Hanna Mikkola via email.
• Participation in the UCLA Health Jonsson Comprehensive Cancer Center Thursday Seminar Series. Held virtually, the Series features invited UCLA and outside faculty.
• Leaders in the Field seminar series where an invited external speaker meets with ERGR program researchers and gives an afternoon presentation followed by an open reception. Please contact Kathrin Plath via email if you are interested in hosting a ERGR leader.

ERGR Bioinformatics Toolbox

Our goal is to develop new omics and bioinformatics methods and make them available to cancer researchers in the JCCC and elsewhere. ERGR Toolbox highlights omics and bioinformatics tools that ERGR members have recently built to uncover gene regulation at increased resolution, define isoforms and transcriptomic states, and identify cancer genome and methylome sequences from cfDNA.

Go to Toolbox

Leadership

Director Kathrin Plath is a Professor of Biological Chemistry. She earned her doctorate degree in cell biology from Humboldt University in Berlin (Germany), performed her postdoctoral studies at UCSF and the Whitehead Institute at MIT, and then joined the faculty at the University of California Los Angeles. Plath's lab uses differentiation and reprogramming processes from and to the pluripotent state as powerful in vitro models for studying the gene-regulatory mechanisms underlying cell fate changes and cellular specification with a particular emphasis on enhancer selection, genome organization, and the role of long-noncoding RNAs. Many of the processes she studies are deregulated in cancers. She serves on the editorial board of Cell, Science, and other journals, has been a Director of the International Society of Stem Cell Research, and is a HHMI Faculty Scholar.

Co-director Dr. Hanna Mikkola is Professor of Molecular, Cell and Developmental Biology. Mikkola became interested in hematology and blood cell development during medical school and did her graduate thesis on defining genetic defects in a congenital bleeding disorder, Factor XIII deficiency. She received MD and PhD degrees in 1997 from the University of Helsinki, Finland, and her interest in hematopoietic stem cell (HSC) biology started during her post-doctoral training in Lund University, Sweden (1998–2000), where she developed lentiviral gene transfer tools to manipulate stem cells. In 2000, Mikkola joined the Dana-Farber Cancer Institute, Harvard Medical School, where she focused on hematopoietic transcription factors, defining mouse HSC development through identifying markers for nascent HSCs, and describing the placenta as a niche for developing HSCs. In 2005, she joined UCLA, where her lab is focused closely on human HSC self-renewal mechanisms and understanding how these mechanisms become imbalanced during HSC culture expansion or in leukemias. Mikkola is the recipient of the Martha Austin Research Award from the Stop Cancer Foundation, and Junior Faculty Scholar awards from the American Society of Hematology and V foundation for Cancer Research, the Scholar Award from the Leukemia & Lymphoma Society, and the prestigious McCulloch and Till award from the International Society for Experimental Hematology.

Upcoming Events

Below is a list of upcoming events of interest to the Epigenomics, RNA and Gene Regulation Research Program and its members. This calendar is updated automatically.

For a list of all upcoming Cancer Center events, please visit our Events Calendar.