Endocrinology

Publications

Primary Research Publications

  1. Ng LL, Harker M, Abel E Dale. Mechanisms of leukocyte sodium influx in essential hypertension, Clinical Science. 1988;75(5):521-69. PMID:3254765. doi: 10.1042/cs0750521.
  2. Ng LL, Harker M, Abel E Dale. Leukocyte sodium content and sodium pump activity in overweight and lean hypertensives, Clinical Endocrinology. 1989;30(2):191-200. PMID:2612017.
  3. Abel E Dale, Ledingham JG. Impaired glucose tolerance in hypertension is associated with impaired insulin release independently of changes in insulin sensitivity, Journal of Hypertension. 1994;12(11):1265-1273. PMID:7868874. doi: 10.1097/00004872-199411000-00009.
  4. Ito M, Grujic D, Abel E Dale, Vidal-Puig A, Lawitts J, Harper ME, Himms-Hagen J, Strosberg AD, Flier FS, Lowell BB. Mice expressing human but not murine beta3-adrenergic receptors under the control of human gene regulatory elements, Diabetes. 1998;47(9):1464-71. PMID:9726236. doi: 10.2337/diabetes.47.9.1464.
  5. Abel E Dale, Kaulbach HC, Tian R, Hopkins JC, Duffy J, Doetschman T, Minnemann T, Boers ME, Hadro E, Oberste-Berghaus C, Quist W, Lowell BB, Ingwall JS, Kahn BB. Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart, Journal of Clinical Investigation. 1999;104(12):1703-14. PMID:10606624. PMCID: 409881. doi: 10.1172/JCI7605.
  6. Abel E Dale, Boers ME, Pazos-Moura C, Moura E, Kaulbach H, Zakaria M, Lowell B, Radovick S, Liberman MC, Wondisford F. Divergent roles for thyroid hormone receptor beta isoforms in the endocrine axis and auditory system, Journal of Clinical Investigation. 1999;104(3):291-300. PMID:10430610. PMCID: 408418. doi: 10.1172/JCI6397.
  7. Abel E Dale, Kaulbach HC, Campos-Barros A, Ahima RS, Boers ME, Hashimoto K, Forrest D, Wondisford FE. Novel insight from transgenic mice into thyroid hormone resistance and the regulation of thyrotropin, Journal of Clinical Investigation. 1999;103(2):271-9. PMID:9916139. PMCID: 407884. doi: 10.1172/JCI5205.
  8. Pazos-Moura C, Abel E Dale, Boers ME, Moura E, Hampton TG, Wang J, Morgan JP, Wondisford FE. Cardiac dysfunction caused by myocardium-specific expression of a mutant thyroid hormone receptor, Circulation Research. 2000;86(6):700-9. PMID:10747007. doi: 10.1161/01.RES.86.6.700.
  9. Zisman A, Peroni OD, Abel E Dale, Michael MD, Mauvais-Jarvis F, Lowell BB, Wojtaszewski JF, Hirshman MF, Virkamaki A, Goodyear LJ, Kahn CR, Kahn BB. Targeted disruption of the glucose transporter 4 selectivity in muscle causes insulin resistance and glucose intolerance, Nature Medicine. 2000;6(8):924-8. PMID:10932232. doi: 10.1038/78693.
  10. Hashimoto K, Curty FH, Borges PP, Lee CE, Abel E Dale, Elmquist JK, Cohen RN, Wondisford FE. An unliganded thyroid hormone receptor causes severe neurological dysfunction, Proceedings of the National Academy of Sciences of the United States of America. 2001;98(7):3998-4003. PMID:11274423. PMCID: 31168. doi: 10.1073/pnas.051454698.
  11. Abel E Dale, Peroni O, Kim JK, Kim YB, Boss O, Hadro E, Minnemann T, Shulman GI, Kahn BB. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver, Nature. 2001;409(6821):729-33. PMID:11217863. doi: 10.1038/35055575.
  12. Abel E Dale, Ashima RS, Boers ME, Elmquist JK, Wondisford FE. Critical role for thyroid hormone receptor beta2 in the regulation of TRH neurons on the paraventricular hypothalamus, Journal of Clinical Investigation. 2001;107(8):1017-23. PMID:11306605. PMCID: 199552. doi: 10.1172/JCI10858.
  13. Tian R, Abel E Dale. Responses of GLUT4-deficient hearts to ischemia underscore the importance of glycolysis, Circulation. 2001;103(24):2961-6. PMID:11413087. doi: 10.1161/01.CIR.103.24.2961.
  14. Pachucki J, Hopkins J, Peeters R, Tu H, Carvalho SD, Kaulbach H, Abel E Dale, Wondisford FE, Ingwall JS, Larsen PR. Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis., Endocrinology. 2001;142(1):13-20. PMID:10932232.
  15. Shiojima I, Yefremashvili M, Luo Z, Kureishi Y, Takahashi A, Tao J, Rosenzweig A, Kahn CR, Abel E Dale, Walsh K. Akt signaling mediates postnatal heart growth in response to insulin and nutritional status, Journal of Biological Chemistry. 2002;277(40):37670-7. PMID:12163490. doi: 10.1074/jbc.M204572200.
  16. Belke DD, Betuing S, Tuttle MJ, Graveleau C, Young ME, Pham M, Zhang D, Cooksey RC, McClain DA, Litwin SE, Taegtmeyer H, Severson D, Kahn CR, Abel E Dale. Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression, Journal of Clinical Investigation. 2002;109(5):629-39. PMID:11877471. PMCID: 150890. doi: 10.1172/JCI13946.
  17. Abel E Dale, Moura EG, Ashima RS, Campos-Barros A, Pazos-Moura CC, Boers ME, Kaulbach HC, Forrest D, Wondisford FE. Dominant inhibition of thyroid hormone action selectivity in the pituitary of thyroid hormone receptor-beta null mice abolished the regulation of thyrotropin by thyroid hormone, Molecular Endocrinology. 2003;17(9):1767-76. PMID:12819298. doi: 10.1210/me.2003-0109.
  18. Hu P, Zhang D, Swenson L, Chakrabarti G, Abel E Dale, Litwin SE. Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload, American Journal of Physiology: Heart and Circulatory Physiology. 2003;285(3):1261-9. PMID:12738623. doi: 10.1152/ajpheart.00108.2003.
  19. Stavinoha MA, RaySpellicy JW, Essop MF, Graveleau C, Abel E Dale, Hart-Sailors ML, Mersmann HJ, Bray MS, Young ME. Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle, American Journal of Physiology: Endocrinology & Metabolism. 2004;287(5):888-95. PMID:15292030. doi: 10.1152/ajpendo.00190.2004.
  20. Shimoni Y, Chuang M, Abel E Dale, Severson DL. Gender-dependent attenuation of cardiac potassium currents in type 2 diabetic db/db mice, The Journal of Physiology. 2004;555(2):345-54. PMID:14694146. PMCID: 1664833. doi: 10.1113/jphysiol.2003.055590.
  21. Mazumder PK, O'Neill BT, Roberts MW, Buchanan J, Yun UJ, Cooksey RC, Boudina S, Abel E Dale. Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts, Diabetes. 2004;53(9):2366-74. PMID:15331547. doi: 10.2337/diabetes.53.9.2366.
  22. Punske BB, Rossi S, Ershler P, Rasmussen I, Abel E Dale. Optical mapping of propagation changes induced by elevated extracellular potassium ion concentration in genetically altered mouse hearts, Journal of Electrocardiology. 2004;37:128-34. PMID:15534822. doi: 10.1016/j.jelectrocard.2004.08.037.
  23. Abel E Dale, Graveleau C, Betuing S, Pham M, Reay PA, Kandror V, Kupriyanova T, Xu Z, Kandror KV. Regulation of insulin-responsive aminopeptidase expression and targeting in the insulin-responsive vesicle compartment of glucose transporter isoform 4-deficient cardiomyocytes, Molecular Endocrinology. 2004;18(10):2491-501. PMID:15231875. doi: 10.1210/me.2004-0175.
  24. Hayashi M, Kim SW, Imanaka-Yoshida K, Yoshida T, Abel E Dale, Eliceiri B, Yang Y, Ulevitch RJ, Lee JD. Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure, Journal of Clinical Investigation. 2004;113(8):1138-48. PMID:15085193. PMCID: 385403. doi: 10.1172/JCI19890.
  25. McQueen AP, Zhang D, Hu P, Zaha VG, Hoffman JL, Yun UJ, Chakrabarti G, Wang Z, Albertine KH, Abel E Dale, Litwin SE. Contractile dysfunction in hypertrophied hearts with deficient insulin receptor signaling: possible role of reduced capillary density, Journal of Molecular and Cellular Cardiology. 2005;39(6):882-92. PMID:16216265. doi: 10.1016/j.yjmcc.2005.07.017.
  26. Rui T, Feng Q, Lei M, Peng T, Zhang J, Xu M, Abel E Dale, Xenocostas A, Kvietys PR. Erythropoietin prevents the acute myocardial inflammatory response induced by ischemia/reperfusion via induction of AP-1, Cardiovascular Research. 2005;65(3):719-27. PMID:15664399. doi: 10.1016/j.cardiores.2004.11.019.
  27. Graveleau C, Zaha VG, Mohajer A, Banerjee RR, Dudley-Rucker N, Steppan CM, Rajala MW, Scherer PE, Ahima RS, Lazar MA, Abel E Dale. Mouse and human resistin impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action, Journal of Biological Chemistry. 2005;280(36):31679-85. PMID:15983036. doi: 10.1074/jbc.M504008200.
  28. Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel E Dale, Semenkovich CF, Kelly DP. PGC-1alpha deficient mice exhibit multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis, PLoS Biology. 2005;3(4):101. PMID:15760270. PMCID: 1064854. doi: 10.1371/journal.pbio.0030101.
  29. Buchanan J, Mazumder PK, Hu P, Chakrabarti G, Roberts MW, Yun UJ, Cooksey RC, Litwin SE, Abel E Dale. Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity, Endocrinology. 2005;146(12):5341-9. PMID:16141388. doi: 10.1210/en.2005-0938.
  30. Boudina S, Sena S, O'Neill BT, Tathireddy P, Young ME, Abel E Dale. Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity, Circulation. 2005;112(17):2686-95. PMID:16246967. doi: 10.1161/CIRCULATIONAHA.105.554360.
  31. Durgan DJ, Hotze MA, Tomlin TM, Egbejimi O, Graveleau C, Abel E Dale, Shaw CA, Bray MS, Hardin PE, Young ME. The intrinsic circadian clock within the cardiomyocyte, American Journal of Physiology: Heart and Circulatory Physiology. 2005;289(4):530-41. PMID:15937094.
  32. Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Bloun M, Lopez M, Meirhaeghe A, Bohlooly YM, Storlien L, Stromstedt M, Snaith M, Ore M, Abel E Dale, Cannon B, Vidal-Puig A. Ablation of PCG-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance, PLoS Biology. 2006;4(11):369. PMID:17090215. PMCID: 1634886. doi: 10.1371/journal.pbio.0040369.
  33. Buerger A, Rozhitskaya O, Sherwood MC, Dorfman AL, Bisping E, Abel E Dale, Pu WT, Izumo S, Jay PY. Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase, Journal of Cardiac Failure. 2006;12(5):392-8. PMID:16762803. doi: 10.1016/j.cardfail.2006.03.002.
  34. Durgan DJ, Smith JK, Hotze MA, Egbejimi O, Cuthbert KD, Zaha VG, Dyck JR, Abel E Dale, Young ME. Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin, American Journal of Physiology: Heart and Circulatory Physiology. 2006;290(6):2480-97. PMID:16428347. doi: 10.1152/ajpheart.01344.2005.
  35. Augustus AS, Buchanan J, Park TS, Hirata K, Noh HL, Sun J, Homma S, Armento J, Abel E Dale, Goldberg IJ. Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction, Journal of Biological Chemistry. 2006;281(13):8716-23. PMID:16410253. doi: 10.1074/jbc.M509890200.
  36. O'Neill BT, Kim J, Wende AR, Theobald HA, Tuinei J, Buchanan J, Guo A, Zaha VG, Davis DK, Schell JC, Boudina S, Wayment B, Litwin SE, Shioi T, Izumo S, Birnbaum MJ, Abel E Dale. A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy, Cell Metabolism. 2007;6(4):294-306. PMID:17908558. PMCID: 2084219. doi: 10.1016/j.cmet.2007.09.001.
  37. Sena S, Rasmussen IR, Wende AR, McQueen AP, Theobald HA, Wilde N, Pereira RO, Litwin SE, Berger JP, Abel E Dale. Cardiac hypertrophy caused by peroxisome proliferator-activated receptor-gamma agonist treatment occurs independently of changes in myocardial insulin signaling, Endocrinology. 2007;148(12):6047-53. PMID:17823261. doi: 10.1210/en.2006-1559.
  38. Benjamin IJ, Guo Y, Srinivasan S, Boudina S, Taylor RP, Rajasekaran NS, Gottlieb R, Wawrousek EF, Abel E Dale, Bolli R. CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice, American Journal of Physiology: Heart and Circulatory Physiology. 2007;293(5):3201-9. PMID:17873008. PMCID: 3683980. doi: 10.1152/ajpheart.01363.2006.
  39. Sano M, Izumi Y, Helenius K, Asakura M, Rossi DJ, Xie M, Taffet G, Hu L, Pautler RG, Wilson CR, Boudina S, Abel E Dale, Taegtmeyer H, Scaglia F, Graham BH, Kralli A, Shimizu M, Tanaka H, Makela TP, Schneider MD. Menage-a-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1, Cell Metabolism. 2007;5(2):129-42. PMID:17276355. doi: 10.1016/j.cmet.2007.01.003.
  40. Hao HX, Cardon CM, Swiatek W, Cooksey RC, Smith TL, Wilde J, Abel E Dale, Boudina S, McClain DA, Rutter J. PAS kinase is required for normal cellular energy balance., Proceedings of the National Academy of Sciences of the United States of America. 2007;104(39):15466-71. PMID:17878307. PMCID: 2000499. doi: 10.1073/pnas.0705407104.
  41. Boudina S, Sena S, Theobald H, Sheng X, Wright JJ, Hu XX, Aziz S, Johnson JI, Bugger H, Zaha VG, Abel E Dale. Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins, Diabetes. 2007;56(10):2457-66. PMID:17623815. doi: 10.2337/db07-0481.
  42. Tabbi-Anneni I, Buchanan J, Cooksey RC, Abel E Dale. Captopril normalizes insulin signaling and insulin-regulated substrate metabolism in obese (ob/ob) mouse hearts, Endocrinology. 2008;149(8):4043-50. PMID:18450963. PMCID: 2488224. doi: 10.1210/en.2007-1646.
  43. Park TS, Hu Y, Noh HL, Drosatos K, Okajima K, Buchanan J, Tuinei J, Homma S, Jiang XC, Abel E Dale, Goldberg IJ. Ceramide is a cardiotoxin in lipotoxic cardiomyopathy, Journal of Lipid Research. 2008;49(10):2101-12. PMID:18515784. PMCID: 2533410. doi: 10.1194/jlr.M800147-JLR200.
  44. Fang C, Gu J, Xie F, Behr M, Yang W, Abel E Dale, Ding X. Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity, Drug Metabolism and Disposition. 2008;36(8):1722-8. PMID:18463097. PMCID: 2575052. doi: 10.1124/dmd.108.021881.
  45. Bray MS, Shaw CA, Moore MW, Garcia RA, Zanquetta MM, Durgan DJ, Jeong WJ, Tsai JY, Bugger H, Zhang D, Rohrwasser A, Rennison JH, Dyck JR, Litwin SE, Hardin PE, Chow CW, Chandler MP, Abel E Dale, Young ME. Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression, American Journal of Physiology: Heart and Circulatory Physiology. 2008;294(2):1036-47. PMID:18156197. PMCID: 2519224. doi: 10.1152/ajpheart.01291.2007.
  46. Yin Z, Jones GN, Towns WH, Zhang X, Abel E Dale, Binkley PF, Jarjoura D, Kirschner LS. Heart-specific ablation of Prkar 1a causes failure of heart development and myxomagenesis, Circulation. 2008;11(1414-22). PMID:18316483. doi: 10.1161/CIRCULATIONAHA.107.759233.
  47. Augustas AS, Buchanan J, Gutman E, Rengo G, Pestell RG, Fortina P, Koch WJ, Bensadoun A, Abel E Dale,Lisanti MP. Hearts lacking caveolin-1 develop hypertrophy with normal cardiac substrate metabolism, Cell Cycle. 2008;7(16):2509-16. PMID:18719368. doi: 10.4161/cc.7.16.6421.
  48. Kim J, Wende AR, Sena S, Theobald HA, Soto J, Sloan C, Wayment BE, Litwin SE, Holzenberger M, LeRoith D, Abel E Dale. Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy, Molecular Endocrinology. 2008;22(11):2531-43. PMID:18801929. PMCID: 2582541. doi: 10.1210/me.2008-0265.
  49. Jouihan HA, Cobine PA, Cooksey RC, Hoagland EA, Boudina S, Abel E Dale, Winge DR, McClain DA. Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis, Molecular Medicine. 2008;14(3-4):98-108. PMID:18317567. PMCID: 2258172. doi: 10.2119/2007-00114.Jouihan.
  50. Amiott EA, Lott P, Kang PB, McCaffery JM, Dimauro S, Flanigan KM, Abel E Dale, Lawson VH, Shaw JM. Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations, Experimental Neurology. 2008;211(1):115-27. PMID:18316077. PMCID: 2409111. doi: 10.1016/j.expneurol.2008.01.010.
  51. Mossalam M, Jeong JH, Abel E Dale, Kim SW, Kim YH. Reversal of oxidative stress in endothelial cells by controlled release of adiponectin, Journal of Controlled Release. 2008;130(3):234-7. PMID:18619503. doi: 10.1016/j.jconrel.2008.06.009.
  52. Augustas AS, Buchanan J, Addya S, Rengo G, Pestell RG, Fortina P, Koch WJ, Bensadoun A, Abel E Dale, Lisanti MP. Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts, American Journal of Physiology - Heart and Circulatory Physiology. 2008;295(2):657-66. PMID:18552160. PMCID: 2519224. doi: 10.1152/ajpheart.00387.2008.
  53. Lehman JJ, Boudina S, Banke NH, Sambandam N, Han X, Young DM, Leone TC, Gross RW, Lewandowski ED, Abel E Dale, Kelly DP. The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis, American Journal of Physiology: Heart and Circulatory Physiology. 2008;295(1):185-96. PMID:18487436. PMCID: 2494758. doi: 10.1152/ajpheart.00081.2008.
  54. Bugger H, Boudina S, Hu XX, Tuinei J, Zaha VG, Theobald HA, Yun UJ, McQueen AP, Wayment B, Litwin SE, Abel E Dale. Type I diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3, Diabetes. 2008;57(11):2924-32. PMID:18678617. PMCID: 2570388. doi: 10.2337/db08-0079.
  55. Bakirtzi K, Belfort G, Lopez-Coviella I, Kuruppu D, Cao L, Abel E Dale, Brownell AL, Kandror KV. Cerebellar neurons possess a vesicular compartment structurally and functionally similar to Glut4-storage vesicles from peripheral insulin-sensitive tissues, Journal of Neurosciences Online. 2009;29(16):5193-201. PMID:19386915. PMCID: 2692175. doi: 10.1523/JNEUROSCI.0858-09.2009.
  56. Boudina S, Bugger H, Sena S, O'Neill BT, Zaha VG, Ilkun O, Wright JJ, Mazumder PK, Palfreyman E, Tidwell TJ, Theobald H, Khalimonchuk O, Wayment B, Sheng X, Rodnick KJ, Centini R, Chen D, Litwin SE, Weimer BE, Abel E Dale. Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart, Circulation. 2009;119(9):1272-83. PMID:19237663. PMCID: 2739097. doi: 10.1161/CIRCULATIONAHA.108.792101.
  57. Symons JD, McMillin SL, Riehle C, Tanner J, Palionyte M, Hillas E, Jones D, Cooksey RC, Birnbaum MJ, McClain DA, Zhang QJ, Gale D, Wilson LJ, Abel E Dale. Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure, Circulation Research. 2009;104(9):1085-94. PMID:19342603. PMCID: 2936913. doi: 10.1161/CIRCRESAHA.108.189316.
  58. Zhang QJ, McMillin SL, Tanner JM, Palionyte M, Abel E Dale, Symons JD. Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signaling kinases, The Journal of Physiology. 2009;587(15):3911-20. PMID:19505983. PMCID: 2746618. doi: 10.1113/jphysiol.2009.172916.
  59. Sena S, Hu P, Zhang D, Wang X, Wayment B, Olsen C, Avelar E, Abel E Dale, Litwin SE. Impaired insulin signaling accelerates cardiac mitochondrial dysfunction after myocardial infarction, Journal of Molecular and Cellular Cardiology. 2009;46(6):910-8. PMID:19249310. PMCID: 2683200. doi: 10.1016/j.yjmcc.2009.02.014.
  60. Liu S, Okada T, Assmann A, Soto J, Liew CW, Bugger H, Shirihai OS, Abel E Dale, Kulkarni RN. Insulin signaling regulates mitochondrial function in pancreatic beta-cells, PLoS ONE. 2009;4(11):7983. PMID:19956695. PMCID: 2776992. doi: 10.1371/journal.pone.0007983.
  61. Ikeda H, Shiojima I, Ozasa Y, Yoshida M, Holzenberger M, Kahn CR, Walsh K, Igarashi T, Abel E Dale, Komuro I. Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy, Journal of Molecular and Cellular Cardiology. 2009;47(5):664-75. PMID:19744489. PMCID: 4886750. doi: 10.1016/j.yjmcc.2009.08.028.
  62. Soesanto W, Lin HY, Hu E, Lefler S, Litwin SE, Sena S, Abel E Dale, Symons JD, Jalili T. Mammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats, Hypertension. 2009;54(6):1321-7. PMID:19884565. PMCID: 2803027. doi: 10.1161/HYPERTENSIONAHA.109.138818.
  63. Wright JJ, Kim J, Buchanan J, Boudina S, Bakirtzi K, Ilkun O, Theobald HA, Cooksey RC, Kandror KV, Abel E Dale. Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding, Cardiovascular Research. 2009;82(2):351-60. PMID:19147655. doi: 10.1093/cvr/cvp017.
  64. Yang S, Liu A, Weidenhammer A, Cooksey RC, McClain D, Kim MK, Aguilera G, Abel E Dale, Chung JH. The role of mPer2 clock gene in glucocorticoid and feeding rhythms, Endocrinology. 2009;150(5):2153-60. PMID:19179447. PMCID: 2671901. doi: 10.1210/en.2008-0705.
  65. Bugger H, Chen D, Riehle C, Soto J, Theobald HA, Hu XX, Ganesan B, Weimer BC, Abel E Dale. Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice, Diabetes. 2009;58(9):1986-97. PMID:19542201. PMCID: 2731527. doi: 10.2337/db09-0259.
  66. O'Grady SP, Wende AR, Remien CH, Valenzuela LO, Enright LE, Chesson LA, Abel E Dale, Cerling TE, Ehleringer JR. Aberrant water homeostasis detected by stable isotope analysis, PLoS ONE. 2010;5(7):11699. PMID:20657736. PMCID: 2908146. doi: 10.1371/journal.pone.0011699.
  67. Griesel BA, Weems J, Russell RA, Abel E Dale, Humphries K, Olson AL. Acute inhibition of fatty acid import inhibits GLIT4 transcription in adipose tissue, but not skeletal muscle tissue, partly through LXR signaling, Diabetes. 2010. PMID:20103707. PMCID: 2844827. doi: 10.2337/db09-1542.
  68. Fang X, Palanivel R, Cresser J, Schram K, Ganguly R, Thong FS, Tuinei J, Xu A, Abel E Dale, Sweeney G. An APPL1-AMOK signaling axis mediates beneficial metabolic effects of adiponectin in the heart, American Journal of Physiology: Endocrinology and Metabolism. 2010;299(5):721-9. PMID:20739511. PMCID: 2980363. doi: 10.1152/ajpendo.00086.2010.
  69. Sloan C, Tuinei J, Nemetz K, Frandsen J, Soto J, Wride N, Sempokuya T, Alegria L, Bugger H, Abel E Dale.Central leptin signaling is required to normalize myocardial fatty acid oxidation rates in caloric restricted ob/ob mice, Diabetes. 2010;60(5):1424-3. PMID:21441440. PMCID: 3292315. doi: 10.2337/db10-1106.
  70. Cooksey RC, Jones D, Gabrielsen S, Huang J, Simcox JA, Luo B, Soesanto YA, Reinhoff H, Abel E Dale,McClain DA. Dietary iron restriction or ion chelation protect from diabetes and loss of beta cell function in the obese (ob/ob lep-/-) mouse, American Journal of Physiology: Endocrinology & Metabolism. 2010. PMID:20354157. PMCID: 2886527. doi: 10.1152/ajpendo.00022.2010.
  71. Shimizu I, Minamino T, Toko H, Okada S, Ikeda H, Yasuda N, Tateno K, Moriya J, Yokoyama MI, Nojima A, Koh GY, Akazawa H, Shiojima I, Kahn CR, Abel E Dale, Komuro I. Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload, Journal of Clinical Investigation. 2010;120:1506-14. PMID:20407209. PMCID: 2860916. doi: 10.1172/JCI40096.
  72. Tanner JM, Kearns DT, Kim BJ, Sloan C, Jia Z, Yang T, Abel E Dale, Symons JD. Fasting-induced reduction in cardiovascular and metabolic variable occur sooner in obese versus lean mice, Experimental Biology and Medicine (Maywood). 2010;235(12):1489-97. PMID:21127345. PMCID: 3367312. doi: 10.1258/ebm.2010.010171.
  73. Wende AR, Soto J, Olsen CD, Pires KM, Schell JC, Larrieu-Lahargue F, Litwin SE, Kakoki M, Takahashi N, Smithies O, Abel E Dale. Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetes akita mice, Endocrinology. 2010;151(8):3536-42. PMID:20501666. PMCID: 2940524. doi: 10.1210/en.2010-0256.
  74. Zhang Y, Soto J, Park K, Viswanath G, Kuwada S, Abel E Dale, Wang L. Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth, Molecular and Cellular Biology. 2010;30(6):1341-56. PMID:20065042. PMCID: 2832505. doi: 10.1128/MCB.01076-09.
  75. Son NH, Yu S, Tuinei J, Arai K, Hamai H, Homma S, Shulman GI, Abel E Dale, Goldberg IJ. PPARgamma-induced cardiolipotoxicity in mice is ameliorated by PPARalpha deficiency despite increases in fatty acid oxidation, Journal of Clinical Investigation. 2010;120(10):3443-54. PMID:20852389. doi: 10.1172/JCI40905.
  76. Banke NH, Wende AR, Leone TC, O'Donnell JM, Abel E Dale, Kelly DP, Lewandowski EP. Preferential oxidation of triacylglyceride-derived fatty acids in heart is augmented by the nuclear receptor PPARalpha, Circulation Research. 2010;107(2):233-41. PMID:20522803. PMCID: 2921193. doi: 10.1161/CIRCRESAHA.110.221713.
  77. Ock S, Lee SH, Ahn J, Lee TJ, Cho CH, Abel E Dale, Kimura S, Kim J. Conditional deletion of insulin receptor in thyrocytes does not affect thyroid structure and function, Endocrine Journal. 2011;58(11):1013-9. PMID:21908931. PMCID: 3471790. doi: 10.1507/endocrj.EJ11-0007.
  78. Pound KM, Arteaga GM, Fasano M, Wilder T, Fischer SK, Warren CM, Wende AR, Farjah M, Abel E Dale, Solaro RJ, Lewandowski ED. Expression of slow skeletal TnI in adult mouse hearts confers metabolic protection to ischemia, Journal of Molecular and Cellular Cardiology. 2011;51(2):236-43. PMID:21640727. PMCID: 3124599. doi: 10.1016/j.yjmcc.2011.05.014.
  79. Huang J, Jones D, Luo B, Sanderson M, Soto J, Abel E Dale, Cooksey RC, McClain DA. Iron overload and diabetes risk: a shift from glucose to fatty acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis, Diabetes. 2011;60(1):80-7. PMID:20876715. PMCID: 3012200. doi: 10.2337/db10-0593.
  80. Symons JD, Hu P, Yang Y, Wang X, Zhang QJ, Wende AR, Sloan CL, Sena S, Abel E Dale, Litwin SE. Knockout of insulin receptors in cardiomyocytes attenuates coronary arterial dysfunction induced by pressure overload, American Journal of Physiology: Heart and Circulatory Physiology. 2011;300(1):374-81. PMID:20971769. PMCID: 3023253. doi: 10.1152/ajpheart.01200.2009.
  81. Young CD, Lewis AS, Rudolph MC, Ruehle MD, Jackman MR, Yun UJ, Ilkun O, Pereira R, Abel E Dale,Anderson SM. Modulation of glucose transporter (GLUT1) expression levels alters mouse mammary tumor cell growth in vitro and in vivo, PLoS ONE. 2011;6(8):23205. PMID:21826239. PMCID: 3149640. doi: 10.1371/journal.pone.0023205.
  82. Poussin C, Ibberson M, Hall D, Ding J, Soto J, Abel E Dale, Thorens B. Oxidative phosphorylation flexibility in the liver of mice resistant to high-fat diet-induced hepatic steatosis, Diabetes. 2011;60(9):2216-24. PMID:21752958. PMCID: 3161312. doi: 10.2337/db11-0338.
  83. Riehle C, Wende AR, Zaha VG, Pires KM, Wayment B, Olsen C, Bugger H, Buchanan J, Wang X, Moreira AB, Doenst T, Medina-Gomez G, Litwin SE, Lelliott CJ, Vidal-Puig A, Abel E Dale. PGC-1beta deficiency accelerates the transition to heart failure in pressure overload hypertrophy, Circulation Research. 2011;109(7):783-93. PMID:21799152. PMCID: 3175248. doi: 10.1161/CIRCRESAHA.111.243964.
  84. Li Y, Ma J, Singh M, Hill D, Greer PA, Arnold JM, Abel E Dale, Peng T. Targeted inhibition of calpain reduces myocardial hypertrophy and fibrosis in mouse models of type 1 diabetes, Diabetes. 2011;60(11):2985-94. PMID:21911754. PMCID: 3198063. doi: 10.2337/db10-1333.
  85. Sohn K, Sachse FB, Moreno AP, Ershler PR, Wende AR, Abel E Dale, Punske BB. The maximal downstroke of epicardial potentials as an index of electrical activity in mouse hearts, IDDD Transactions on Biomedical Engineering. 2011;58(11):3175-83. PMID:21859611. doi: 10.1109/TBME.2011.2164075.
  86. Gounder SS, Kannan S, Devadoss D, Miller CJ, Whitehead KJ, Odelberg SJ, Firpo MA, Paine, 3rd R, Hoidal JR, Abel ED, Rajasekaran NS. Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training., PloS one. 2012 January 1;7(9):e45697. PMID:23029187. PMCID: 3454427. doi: 10.1371/journal.pone.0045697.
  87. Sohn K, Wende AR, Abel E Dale, Moreno AP, Sachse FB, Punske BB. Absence of glucose transporter 4 diminishes electrical activity of mouse hearts during hypoxia, Experimental Physiology. 2012;98(3):746-57. PMID:23180812. doi: 10.1113/expphysiol.2012.070235.
  88. Zhang QJ, Holland WL, Wilson L, Tanner JM, Kearns D, Cahoon JM, Dix P, Losee J, Duncan B, Gale D, Kowalski CA, Deeter N, Nichols A, Michole Deesing M, Arrant C, Ruan T, Boehme C, McCamey DR, Rou J, Ambal K, Narra KK, Summers SA, Abel E Dale, Symons JD. Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex, Diabetes. 2012;61(7):1848-59. PMID:22586587. PMCID: 3379648. doi: 10.2337/db11-1399.
  89. Li Y, Wende AR, Nunthakungwan O, Huang Y, Hu E, Jin H, Boudina S, Abel E Dale, Jalili T. Cytosolic, but not mitochondrial, oxidative stress likely contributes to cardiac hypertrophy resulting from cardiac specific GLIT4 deletion in mice, The FEBS Journal. 2012;279(4):599-611. PMID:22221582. PMCID: 3267000. doi: 10.1111/j.1742-4658.2011.08450.x.
  90. Boudina S, Sena S, Sloan C, Tebbi A, Han YH, O'Neill BT, Cooksey RC, Jones D, McClain DA, Abel E Dale. Early mitochondrial adaptations in skeletal muscle to diet-induced obesity are strain dependent and determine oxidative stress and energy expenditure but not insulin sensitivity, Endocrinology. 2012;153(6):2677-88. PMID:22510273. PMCID: 3359615. doi: 10.1210/en.2011-2147.
  91. Troncoso R, Vicencio JM, Parra V, Nemchenko A, Kawashima Y, del Campo A, Toro B, Battiprolu PK, Aranguiz P, Chiong M, Yakar S, Gillette TG, Hill JA, Abel E Dale, LeRoith D, Lavandero S. Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy, Cardiovascular Research. 2012;93:320-9. PMID:22135164. PMCID: 3286200. doi: 10.1093/cvr/cvr321.
  92. Bugger H, Riehle C, Jaishy B, Wende AR, Tuinei J, Chen D, Soto J, Pires KM, Boudina S, Theobald HA, Luptak I, Wayment B, Wang X, Sheldon E, Litwin SE, Weimer BC, Abel E Dale. Genetic loss of insulin receptors worsens cardiac efficiency in diabetes, Journal of Molecular and Cellular Cardiology. 2012. PMID:22342406. PMCID: 3327790. doi: 10.1016/j.yjmcc.2012.02.001.
  93. Ishiwata T, Orosz A, Wang X, Mustafi SB, Pratt GW, Christians ES, Boudina S, Abel E Dale, Benjamin IJ. HSPB2 is dispensable for the cardiac hypertrophic response but reduces mitochondrial energetics following pressure overload in mice, PLoS ONE. 2012;7(8):42118. PMID:22870288. PMCID: 3411653. doi: 10.1371/journal.pone.0042118.
  94. Chen JX, Krane M, Deutsch MA, Wang L, Rav-Acha M, Gregoire S, Engles M, Rajarajan K, Karra R, Abel E Dale, Wu JC, Milan D, Wu SM. Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, Tbx5, Circulation Research. 2012. PMID:22581928. PMCID: 3390172. doi: 10.1161/CIRCRESAHA.112.270264.
  95. Han CY, Umemoto T, Omer M, Den Hartigh LJ, Chiba T, LeBoeuf R, Buller CL, Sweet IR, Pennathur S, Abel E Dale, Chiat A. NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes, Journal of Biological Chemistry. 2012. PMID:22287546. PMCID: 3322984. doi: 10.1074/jbc.M111.304998.
  96. Ock S, Ahn J, Lee SH, Park H, Son JW, Oh JG, Yang DK, Lee WS, Kim HS, Rho J, Oh GT, Abel E Dale, Park WJ, Min JK, Kim J. Receptor activator of nuclear factor-kB ligand (RANKL) is a novel inducer of myocardial inflammation, Cardiovascular Research. 2012. PMID:22298642. PMCID: 3454427. doi: 10.1093/cvr/cvs078.
  97. Marcus RL, Addison O, LaStayo PC, Hungerford R, Wende AR, Hoffman JM, Abel E Dale, McClain DA. Regional muscle glucose uptake remains elevated 1 week after cessation of resistance training independent of altered insulin sensitivity response in older adults with type 2 diabetes, Journal of Endocrinological Investigation. 2012. PMID:22522495. doi: 10.3275/8333.
  98. Manso AM, Li R, Monkley SJ, Cruz NM, Ong S, Lao DH, Koshman YE, Gu Y, Peterson KL, Chen J, Abel E Dale, Samarel AM, Critchley DR, Ross RS. Talin 1 has unique expressions vs. talin 2 in the heart and modifies the hypertrophic response to pressure overload, Journal of Biological Chemistry. 2012;288(6):4252-64. PMID:23266827. PMCID: 3567677. doi: 10.1074/jbc.M112.427484.
  99. Boudina S, Han YH, Pei S, Tidwell TJ, Henrie B, Tuinei J, Olsen C, Sena S, Abel E Dale. UCP3 regulates cardiac efficiency and mitochondrial coupling in high fat-fed mice but not in leptin-deficient mice, Diabetes. 2012;61(2):3260-9. PMID:22912419. PMCID: 3501860. doi: 10.2337/db12-0063.
  100. Zhu Y, Pereira RO, O'Neill BT, Riehle C, Ilkun O, Wende AR, Rawlings TA, Zhang YC, Zhang Q, Klip A, Shiojima I, Walsh K, Abel ED. Cardiac PI3K-Akt impairs insulin-stimulated glucose uptake independent of mTORC1 and GLUT4 translocation., Molecular endocrinology (Baltimore, Md.). 2013 January 1;27(1):172-84. PMID:23204326. doi: 10.1210/me.2012-1210.
  101. Shin J, Lee SH, Kwon MC, Yang DK, Seo HR, Kim J, Kim YY, Im SK, Abel ED, Kim KT, Park WJ, Kong YY. Cardiomyocyte specific deletion of Crif1 causes mitochondrial cardiomyopathy in mice., PloS one. 2013 January 1;8(1):e53577. PMID:23308255. doi: 10.1371/journal.pone.0053577.
  102. Zhu Y, Pires KM, Whitehead KJ, Olsen CD, Wayment B, Zhang YC, Bugger H, Ilkun O, Litwin SE, Thomas G, Kozma SC, Abel ED. Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth., PloS one. 2013 January 1;8(1):e54221. PMID:23342106. PMCID: 3544830. doi: 10.1371/journal.pone.0054221.
  103. Shibayama J, Taylor TG, Venable PW, Rhodes NL, Gil RB, Warren M, Wende AR, Abel ED, Cox J, Spitzer KW, Zaitsev AV. Metabolic determinants of electrical failure in ex-vivo canine model of cardiac arrest: evidence for the protective role of inorganic pyrophosphate., PloS one. 2013 January 1;8(3):e57821. PMID:23520482. doi: 10.1371/journal.pone.0057821.
  104. Mossalam M, Soto J, Lim CS, Abel ED. Solid phase synthesis of mitochondrial triphenylphosphonium-vitamin E metabolite using a lysine linker for reversal of oxidative stress., PloS one. 2013 January 1;8(1):e53272. PMID:23341934. PMCID: 3544826. doi: 10.1371/journal.pone.0053272.
  105. Bosse JD, Lin HY, Sloan C, Zhang QJ, Abel ED, Pereira TJ, Dolinsky VW, Symons JD, Jalili T. A low-carbohydrate/high-fat diet reduces blood pressure in spontaneously hypertensive rats without deleterious changes in insulin resistance., American journal of physiology. Heart and circulatory physiology. 2013 June 15;304(12):H1733-42. PMID:23604708. doi: 10.1152/ajpheart.00631.2012.
  106. Zhu Y, Soto J, Anderson B, Riehle C, Zhang YC, Wende AR, Jones D, McClain DA, Abel ED. Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α., American journal of physiology. Heart and circulatory physiology. 2013 July 1;305(1):H41-51. PMID:23624629. doi: 10.1152/ajpheart.00877.2012.
  107. Pereira RO, Wende AR, Olsen C, Soto J, Rawlings T, Zhu Y, Anderson SM, Abel ED. Inducible overexpression of GLUT1 prevents mitochondrial dysfunction and attenuates structural remodeling in pressure overload but does not prevent left ventricular dysfunction., Journal of the American Heart Association. 2013 September 19;2(5):e000301. PMID:24052497. doi: 10.1161/JAHA.113.000301.
  108. Kannan S, Muthusamy VR, Whitehead KJ, Wang L, Gomes AV, Litwin SE, Kensler TW, Abel ED, Hoidal JR, Rajasekaran NS. Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy., Cardiovascular research. 2013 October 1;100(1):63-73. PMID:23761402. PMCID: 3778956. doi: 10.1093/cvr/cvt150.
  109. Fullmer TM, Pei S, Zhu Y, Sloan C, Manzanares R, Henrie B, Pires KM, Cox JE, Abel ED, Boudina S. Insulin suppresses ischemic preconditioning-mediated cardioprotection through Akt-dependent mechanisms., Journal of molecular and cellular cardiology. 2013 November 1;64:20-9. PMID:23994159. PMCID: 3835741. doi: 10.1016/j.yjmcc.2013.08.005.
  110. Ock S, Ahn J, Lee SH, Kang H, Offermanns S, Ahn HY, Jo YS, Shong M, Cho BY, Jo D, Abel ED, Lee TJ, Park WJ, Lee IK, Kim J. IGF-1 receptor deficiency in thyrocytes impairs thyroid hormone secretion and completely inhibits TSH-stimulated goiter., FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2013 December 1;27(12):4899-908. PMID:23982142. doi: 10.1096/fj.13-231381.
  111. Riehle C, Wende AR, Sena S, Pires KM, Pereira RO, Zhu Y, Bugger H, Frank D, Bevins J, Chen D, Perry CN, Dong XC, Valdez S, Rech M, Sheng X, Weimer BC, Gottlieb RA, White MF, Abel ED. Insulin receptor substrate signaling suppresses neonatal autophagy in the heart., The Journal of clinical investigation. 2013 December 1;123(12):5319-33. PMID:24177427. PMCID: 3859408. doi: 10.1172/JCI71171.
  112. Zhu Y, Pereira RO, O'Neill BT, Riehle C, Ilkun O, Wende AR, Rawlings TA, Zhang YC, Zhang Q, Klip A, Shiojima I, Walsh K, Abel E Dale. Cardiac PI3K-Akit impairs insulin-stimulated glucose uptake independent of mTORC1 and GLUT4 translocation, Molecular Endocrinology. 2013;27(1):172-84. PMID:23204326. PMCID: 3545208. doi: 10.1210/me.2012-1210.
  113. Dai J, Matsui T, Abel ED, Dedhar S, Gerszten RE, Seidman CE, Seidman JG, Rosenzweig A. Deep sequence analysis of gene expression identifies osteopontin as a downstream effector of integrin-linked kinase (ILK) in cardiac-specific ILK knockout mice., Circulation. Heart failure. 2014 January 1;7(1):184-93. PMID:24319095. PMCID: 3950354. doi: 10.1161/CIRCHEARTFAILURE.113.000649.
  114. Parra V, Verdejo HE, Iglewski M, Del Campo A, Troncoso R, Jones D, Zhu Y, Kuzmicic J, Pennanen C, Lopez-Crisosto C, Jaña F, Ferreira J, Noguera E, Chiong M, Bernlohr DA, Klip A, Hill JA, Rothermel BA, Abel ED, Zorzano A, Lavandero S. Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 signaling pathway., Diabetes. 2014 January 1;63(1):75-88. PMID:24009260. doi: 10.2337/db13-0340.
  115. Guzman J, Jauregui AN, Merscher-Gomez S, Maiguel D, Muresan C, Mitrofanova A, Diez-Sampedro A, Szust J, Yoo TH, Villarreal R, Pedigo C, Molano RD, Johnson K, Kahn B, Hartleben B, Huber TB, Saha J, Burke, 3rd GW, Abel ED, Brosius FC, Fornoni A. Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy., Diabetes. 2014 February 1;63(2):701-14. PMID:24101677. PMCID: 3900538. doi: 10.2337/db13-0752.
  116. Lopez-Izquierdo A, Pereira RO, Wende AR, Punske BB, Abel ED, Tristani-Firouzi M. The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization., American journal of physiology. Heart and circulatory physiology. 2014 March 1;306(5):H747-54. PMID:24375641. PMCID: 3949065. doi: 10.1152/ajpheart.00849.2013.
  117. Caro-Maldonado A, Wang R, Nichols AG, Kuraoka M, Milasta S, Sun LD, Gavin AL, Abel ED, Kelsoe G, Green DR, Rathmell JC. Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells, Journal of immunology. 2014 April 15;192(8):3626-36. PMID:24616478. PMCID: 3984038. doi: 10.4049/jimmunol.1302062.
  118. Pereira RO, Wende AR, Olsen C, Soto J, Rawlings T, Zhu Y, Riehle C, Abel ED. GLUT1 deficiency in cardiomyocytes does not accelerate the transition from compensated hypertrophy to heart failure, Journal of molecular and cellular cardiology. 2014 July 1;72:95-103. PMID:24583251. PMCID: 4037364. doi: 10.1016/j.yjmcc.2014.02.011.
  119. Macintyre AN, Gerriets VA, Nichols AG, Michalek RD, Rudolph MC, Deoliveira D, Anderson SM, Abel ED, Chen BJ, Hale LP, Rathmell JC. The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function., Cell metabolism. 2014 July 1;20(1):61-72. PMID:24930970. PMCID: 4079750. doi: 10.1016/j.cmet.2014.05.004.
  120. Fu Q, Xu B, Liu Y, Parikh D, Li J, Li Y, Zhang Y, Riehle C, Zhu Y, Rawlings T, Shi Q, Clark RB, Chen X, Abel ED, Xiang YK. Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts., Diabetes. 2014 August 1;63(8):2676-89. PMID:24677713. PMCID: 4113065. doi: 10.2337/db13-1763.
  121. Pereira RO, Wende AR, Crum A, Hunter D, Olsen CD, Rawlings T, Riehle C, Ward WF, Abel ED. Maintaining PGC-1α expression following pressure overload-induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function., FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2014 August 1;28(8):3691-702. PMID:24776744. PMCID: 4101649. doi: 10.1096/fj.14-253823.
  122. Riehle C, Wende AR, Zhu Y, Oliveira KJ, Pereira RO, Jaishy BP, Bevins J, Valdez S, Noh J, Kim BJ, Moreira AB, Weatherford ET, Manivel R, Rawlings TA, Rech M, White MF, Abel ED. Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training., Molecular and cellular biology. 2014 September 15;34(18):3450-60. PMID:25002528. PMCID: 4135616. doi: 10.1128/MCB.00426-14.
  123. Liu T, Kishton RJ, Macintyre AN, Gerriets VA, Xiang H, Liu X, Abel ED, Rizzieri D, Locasale JW, Rathmell JC. Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis., Cell death & disease. 2014 October 16;5:e1470. PMID:25321477. PMCID: 4237255. doi: 10.1038/cddis.2014.431.
  124. Koentges C, König A, Pfeil K, Hölscher ME, Schnick T, Wende AR, Schrepper A, Cimolai MC, Kersting S, Hoffmann MM, Asal J, Osterholt M, Odening KE, Doenst T, Hein L, Abel ED, Bode C, Bugger H. Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1., Basic research in cardiology. 2015 January 1;110(4):37. PMID:25982881. doi: 10.1007/s00395-015-0495-4.
  125. Wende AR, O'Neill BT, Bugger H, Riehle C, Tuinei J, Buchanan J, Tsushima K, Wang L, Caro P, Guo A, Sloan C, Kim BJ, Wang X, Pereira RO, McCrory MA, Nye BG, Benavides GA, Darley-Usmar VM, Shioi T, Weimer BC,Abel ED. Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes., Molecular and cellular biology. 2015 March 1;35(5):831-46. PMID:25535334. PMCID: 4323486. doi: 10.1128/MCB.01109-14.
  126. Jaishy B, Zhang Q, Chung HS, Riehle C, Soto J, Jenkins S, Abel P, Cowart LA, Van Eyk JE, Abel ED. Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity., Journal of lipid research. 2015 March 1;56(3):546-61. PMID:25529920. PMCID: 4340303. doi: 10.1194/jlr.M055152.
  127. Winkler EA, Nishida Y, Sagare AP, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wenby RB, Soto J, Abel ED, Makshanoff J, Zuniga E, De Vivo DC, Zlokovic BV. GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration., Nature neuroscience. 2015 April 1;18(4):521-30. PMID:25730668. PMCID: 4734893. doi: 10.1038/nn.3966.
  128. Rasmussen TP, Wu Y, Joiner ML, Koval OM, Wilson NR, Luczak ED, Wang Q, Chen B, Gao Z, Zhu Z, Wagner BA, Soto J, McCormick ML, Kutschke W, Weiss RM, Yu L, Boudreau RL, Abel ED, Zhan F, Spitz DR, Buettner GR, Song LS, Zingman LV, Anderson ME. Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart., Proceedings of the National Academy of Sciences of the United States of America. 2015 July 21;112(29):9129-34. PMID:26153425. PMCID: 4517214. doi: 10.1073/pnas.1504705112.
  129. Ilkun O, Wilde N, Tuinei J, Pires KM, Zhu Y, Bugger H, Soto J, Wayment B, Olsen C, Litwin SE, Abel ED. Antioxidant treatment normalizes mitochondrial energetics and myocardial insulin sensitivity independently of changes in systemic metabolic homeostasis in a mouse model of the metabolic syndrome., Journal of molecular and cellular cardiology. 2015 August 1;85:104-16. PMID:26004364. PMCID: 4530070. doi: 10.1016/j.yjmcc.2015.05.012.
  130. Liao X, Zhang R, Lu Y, Prosdocimo DA, Sangwung P, Zhang L, Zhou G, Anand P, Lai L, Leone TC, Fujioka H, Ye F, Rosca MG, Hoppel CL, Schulze PC, Abel ED, Stamler JS, Kelly DP, Jain MK. Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis., The Journal of clinical investigation. 2015 September 1;125(9):3461-76. PMID:26241060. PMCID: 4588311. doi: 10.1172/JCI79964.
  131. Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, Tsui YC, Cui G, Micevic G, Perales JC, Kleinstein SH, Abel ED, Insogna KL, Feske S, Locasale JW, Bosenberg MW, Rathmell JC, Kaech SM. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses., Cell. 2015 September 10;162(6):1217-28. PMID:26321681. PMCID: 4567953. doi: 10.1016/j.cell.2015.08.012.
  132. Bharath LP, Ruan T, Li Y, Ravindran A, Wan X, Nhan JK, Walker ML, Deeter L, Goodrich R, Johnson E, Munday D, Mueller R, Kunz D, Jones D, Reese V, Summers SA, Babu PV, Holland WL, Zhang QJ, Abel ED, Symons JD. Ceramide-Initiated Protein Phosphatase 2A Activation Contributes to Arterial Dysfunction In Vivo., Diabetes. 2015 November 1;64(11):3914-26. PMID:26253611. PMCID: 4613970. doi: 10.2337/db15-0244.
  133. Noh J, Wende AR, Olsen CD, Kim B, Bevins J, Zhu Y, Zhang QJ, Riehle C, Abel ED. Phosphoinositide dependent protein kinase 1 is required for exercise-induced cardiac hypertrophy but not the associated mitochondrial adaptations., Journal of molecular and cellular cardiology. 2015 December 1;89(Pt B):297-305. PMID:26476238. PMCID: 4689617. doi: 10.1016/j.yjmcc.2015.10.015.
  134. Ock S, Lee WS, Ahn J, Kim HM, Kang H, Kim HS, Jo D, Abel ED, Lee TJ, Kim J. Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in Male Mice., Endocrinology. 2016 January 1;157(1):336-45. PMID:26469138. PMCID: 4701888. doi: 10.1210/en.2015-1709.
  135. Ni R, Zheng D, Xiong S, Hill DJ, Sun T, Gardiner RB, Fan GC, Lu Y, Abel ED, Greer PA, Peng T. Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy., Diabetes. 2016 January 1;65(1):255-68. PMID:26470784. PMCID: 4686953. doi: 10.2337/db15-0963.
  136. Park SY, Rossman MJ, Gifford JR, Bharath LP, Bauersachs J, Richardson RS, Abel ED, Symons JD, Riehle C. Exercise training improves vascular mitochondrial function., American Journal of Physiology. Heart and Circulatory Physiology. 2016 April 1;310(7):H821-9. PMID:26825520. PMCID: 4867356. doi: 10.1152/ajpheart.00751.2015.
  137. Kishton RJ, Barnes CE, Nichols AG, Cohen S, Gerriets VA, Siska PJ, Macintyre AN, Goraksha-Hicks P, de Cubas AA, Liu T, Warmoes MO, Abel ED, Yeoh AE, Gershon TR, Rathmell WK, Richards KL, Locasale JW, Rathmell JC. AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival., Cell metabolism. 2016 April 12;23(4):649-62. PMID:27076078. doi: 10.1016/j.cmet.2016.03.008.
  138. O'Neill BT, Lee KY, Klaus K, Softic S, Krumpoch MT, Fentz J, Stanford KI, Robinson MM, Cai W, Kleinridders A, Pereira RO, Hirshman MF, Abel ED, Accili D, Goodyear LJ, Nair KS, Kahn CR. Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis., The Journal of clinical investigation. 2016 September 1;126(9):3433-46. PMID:27525440. doi: 10.1172/JCI86522.
  139. Trammell SA, Schmidt MS, Weidemann BJ, Redpath P, Jaksch F, Dellinger RW, Li Z, Abel ED, Migaud ME, Brenner C. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans., Nature communications. 2016 October 10;7:12948. PMID:27721479. PMCID: PMC5062546. doi: 10.1038/ncomms12948.
  140. Diakos N, Navankasattusas S, Abel E, Rutter J, McCreath L, Ferrin P, Park S, Richardson R, Deberardinis R, Cox J, Kfoury A, Selzman C, Stehlik J, JF, Li D, Drakos S. Evidence of glycolysis upregulation and pyruvate mitochondrial oxidation mismatch during mechanical uploading of the failing human heart: implications for cardiac reloading and conditioning., J American Coll Cardoil, Basic to Translational Science. 2016 October;1:432-444. PMID:28497127. doi: 10.1016/j.jacbts.2016.06.009.
  141. Wang Q, Liu Y, Fu Q, Xu B, Zhang Y, Kim S, Tan R, Barbagallo F, West TM, Anderson EJ, Wei W, Abel ED, Xiang YK. Inhibiting Insulin-Mediated β2AR Activation Prevents Diabetes-Associated Cardiac Dysfunction., Circulation. 2016 November 4. PMID:27815373. doi: 10.1161/CIRCULATIONAHA.116.022281.
  142. Wellberg EA, Johnson S, Finlay-Schultz J, Lewis AS, Terrell KL, Sartorius CA, Abel ED, Muller WJ, Anderson SM. The glucose transporter GLUT1 is required for ErbB2-induced mammary tumorigenesis., Breast cancer research : BCR. 2016 December 20;18(1):131. PMID:27998284. PMCID: PMC5168867. doi: 10.1186/s13058-016-0795-0.
  143. Pereira RO, Tadinada SM, Zasadny FM, Oliveira KJ, Pires KM, Olvera A, Jeffers J, Souvenir R, Mcglauflin R, Seei A, Funari T, Sesaki H, Potthoff MJ, Adams CM, Anderson EJ, Abel ED. OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance, EMBO Journal. 2017 January 1. doi: 10.15252/embj.201696179.
  144. Rines AK, Chang HC, Wu R, Sato T, Khechaduri A, Kouzu H, Shapiro J, Shang M, Burke MA, Jiang X, Chen C, Rawlings TA, Lopaschuk GD, Schumacker PT, Abel ED, Ardehali H. Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling., Nature communications. 2017 January 24;8:14095. PMID:28117339. PMCID: PMC5286102. doi: 10.1038/ncomms14095.
  145. Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Dale Abel E, Samuel I, Smith JK, Cao L, Sah R. SWELL1 is a regulator of adipocyte size, insulin signaling and glucose homeostasis, Nature Cell Biology. 2017 May 1;19(5):504-517. PMID:28561048. doi: 10.1038/ncb3514.
  146. Park SJ, Gavrilova O, Brown AL, Soto JE, Bremner S, Kim J, Xu X, Yang S, Um JH, Koch LG, Britton SL, Lieber RL, Philp A, Baar K, Kohama SG, Abel ED, Kim MK, Chung JH. DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging, Cell Metabolism. 2017 May 2;25(5):1135-1146.e7. PMID:28467930. PMCID: PMC5485859. doi: 10.1016/j.cmet.2017.04.008.
  147. Fidler TP, Middleton E, Rowley JW, Boudreau LH, Campbell RA, Souvenir R, Funari T, Tessandier N, Boilard E, Weyrich AS, Abel ED. Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation, Arteriosclerosis, Thrombosis, and Vascular Biology. 2017 June 29. PMID:28663252. doi: 10.1161/ATVBAHA.117.309184.
  148. Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrch AS, Abel ED. Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function, Cell Reports. 2017 July 25;20(4):881-894. PMID:28746873. doi: 10.1016/j.celrep.2017.06.083.
  149. Wende AR, Kim J, Holland W, Wayment BE, O'Neill BT, Tuinei J, Brahma MK, Pepin ME, McCrory MA, Luptak I, Halade GV, Litwin SE, Abel ED. Glucose transporter 4 (GLUT4) deficient hearts develop maladaptive hypertrophy in response to physiologic or pathologic stresses., American journal of physiology. Heart and circulatory physiology. 2017 August 19:ajpheart.00101.2017. PMID:28822962. doi: 10.1152/ajpheart.00101.2017.
  150. McGinnis GR, Tang Y, Brewer RA, Brahma MK, Stanley HL, Shanmugam G, Rajasekaran NS, Rowe GC, Frank SJ, Wende AR, Abel ED, Taegtmeyer H, Litovsky S, Darley-Usmar V, Zhang J, Chatham JC, Young ME. Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart., Journal of molecular and cellular cardiology. 2017 September 1;110:80-95. PMID:28736261. PMCID: PMC5586500. doi: 10.1016/j.yjmcc.2017.07.005.
  151. Steinhorn B, Sartoretto JL, Sorrentino A, Romero N, Kalwa H, Abel ED, Michel T. Insulin-dependent metabolic and inotropic responses in the heart are modulated by hydrogen peroxide from NADPH-oxidase isoforms NOX2 and NOX4., Free radical biology & medicine. 2017 September 14;113:16-25. PMID:28917508. doi: 10.1016/j.freeradbiomed.2017.09.006.
  152. Fidler TP, Rowley JW, Araujo C, Boudreau LH, Marti A, Souvenir R, Dale K, Boilard E, Weyrich AS, Abel ED. Superoxide Dismutase 2 is dispensable for platelet function., Thrombosis and haemostasis. 2017 October 5;117(10):1859-1867. PMID:28771279. PMCID: PMC5894334. doi: 10.1160/TH17-03-0174.
  153. Tsushima K, Bugger H, Wende AR, Soto J, Jenson GA, Tor AR, McGlauflin R, Kenny HC, Zhang Y, Souvenir R, Hu XX, Black CL, Pereira RO, Lira VA, Spitzer K, Sharp TL, Shoghi KI, Sparagna GC, Rog-Zielinska EA, Kohl P, Khalimonchuk O, Schaffer JE, Abel ED. Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induces Post-Translational Modifications of AKAP121, DRP1 and OPA1 That Promote Mitochondrial Fission., Circulation research. 2017 November 1. PMID:29092894. doi: 10.1161/CIRCRESAHA.117.311307.
  154. Pires KM, Buffolo M, Schaaf C, David Symons J, Cox J, Abel ED, Selzman CH, Boudina S. Activation of IGF-1 receptors and Akt signaling by systemic hyperinsulinemia contributes to cardiac hypertrophy but does not regulate cardiac autophagy in obese diabetic mice., Journal of molecular and cellular cardiology. 2017 December 1;113:39-50. PMID:28987875. doi: 10.1016/j.yjmcc.2017.10.001.
  155. Nabeebaccus AA, Zoccarato A, Hafstad AD, Santos CX, Aasum E, Brewer AC, Zhang M, Beretta M, Yin X, West JA, Schröder K, Griffin JL, Eykyn TR, Abel ED, Mayr M, Shah AM. Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation., JCI insight. 2017 December 21;2(24). PMID:29263294. doi: 10.1172/jci.insight.96184.
  156. Abel ED. MITOCHONDRIAL DYNAMICS AND METABOLIC REGULATION IN CARDIAC AND SKELETAL MUSCLE., Transactions of the American Clinical and Climatological Association. 2018 January 1;129:266-278. PMID:30166722. PMCID: PMC6116613.
  157. Swarup A, Bell BA, Du J, Han JYS, Soto J, Abel ED, Bravo-Nuevo A, FitzGerald PG, Peachey NS, Philp NJ. Deletion of GLUT1 in mouse lens epithelium leads to cataract formation., Experimental eye research. 2018 March 28. PMID:29604281. doi: 10.1016/j.exer.2018.03.021.
  158. Ock S, Lee WS, Kim HM, Park KS, Kim YK, Kook H, Park WJ, Lee TJ, Abel ED, Kim J. Connexin43 and zonula occludens-1 are targets of Akt in cardiomyocytes that correlate with cardiac contractile dysfunction in Akt deficient hearts., Biochimica et biophysica acta. 2018 April 1;1864(4 Pt A):1183-1191. PMID:29378301. doi: 10.1016/j.bbadis.2018.01.022.
  159. Zhang Z, Zi Z, Lee EE, Zhao J, Contreras DC, South AP, Abel ED, Chong BF, Vandergriff T, Hosler GA, Scherer PE, Mettlen M, Rathmell JC, DeBerardinis RJ, Wang RC. Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis., Nature medicine. 2018 April 16. PMID:29662201. doi: 10.1038/s41591-018-0003-0.
  160. Zhou G, Wu J, Gu C, Wang B, Abel ED, Cheung AK, Huang Y. Prorenin independently causes hypertension and renal and cardiac fibrosis in cyp1a1-prorenin transgenic rats., Clinical science (London, England : 1979). 2018 May 30. PMID:29848510. doi: 10.1042/CS20171659.
  161. Zhang J, Abel ED. Effective Metabolic Approaches for the Energy Starved Failing Heart: Bioenergetic Resiliency via Redundancy or Something Else?, Circulation research. 2018 July 20;123(3):329-331. PMID:30026379. PMCID: PMC6055933. doi: 10.1161/CIRCRESAHA.118.313308.
  162. Ock S, Ahn J, Lee SH, Kim HM, Kang H, Kim YK, Kook H, Park WJ, Kim S, Kimura S, Jung CK, Shong M, Holzenberger M, Abel ED, Lee TJ, Cho BY, Kim HS, Kim J. Thyrocyte-specific deletion of insulin and IGF-1 receptors induces papillary thyroid carcinoma-like lesions through EGFR pathway activation., International journal of cancer. 2018 November 15;143(10):2458-2469. PMID:30070361. doi: 10.1002/ijc.31779.
  163. Lee SY, Abel ED, Long F. Glucose metabolism induced by Bmp signaling is essential for murine skeletal development., Nature communications. 2018 November 16;9(1):4831. PMID:30446646. PMCID: PMC6240091. doi: 10.1038/s41467-018-07316-5.
  164. Swarup A, Samuels IS, Bell BA, Han JYS, Du J, Massenzio E, Abel ED, Boesze-Battaglia K, Peachey NS, Philp NJ. Modulating GLUT1 expression in the RPE decreases glucose levels in the retina: Impact on photoreceptors and Müller glial cells., American journal of physiology. Cell physiology. 2018 November 21. PMID:30462537. doi: 10.1152/ajpcell.00410.2018.
  165. Berry JL, Zhu W, Tang YL, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang HT, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J. Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure., Circulation research. 2019 January 4;124(1):161-169. PMID:30605412. doi: 10.1161/CIRCRESAHA.118.314216.
  166. Freemerman AJ, Zhao L, Pingili AK, Teng B, Cozzo AJ, Fuller AM, Johnson AR, Milner JJ, Lim MF, Galanko JA, Beck MA, Bear JE, Rotty JD, Bezavada L, Smallwood HS, Puchowicz MA, Liu J, Locasale JW, Lee DP, Bennett BJ, Abel ED, Rathmell JC, Makowski L. Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1., Journal of immunology (Baltimore, Md. : 1950). 2019 January 18. PMID:30659108. doi: 10.4049/jimmunol.1800002.
  167. Fidler TP, Marti A, Gerth K, Middleton EA, Campbell RA, Rondina MT, Weyrich AS, Abel ED. Glucose Metabolism is Required for Platelet Hyperactivation in a Murine Model of Type 1 Diabetes Mellitus., Diabetes. 2019 February 14. PMID:30765335. doi: 10.2337/db18-0981.
  168. Soto JE, Burnett CML, Ten Eyck P, Abel ED, Grobe JL. Comparison of the Effects of High-Fat Diet on Energy Flux in Mice Using Two Multiplexed Metabolic Phenotyping Systems., Obesity (Silver Spring, Md.). 2019 April 2. PMID:30938081. doi: 10.1002/oby.22441.
  169. Koval OM, Nguyen EK, Santhana V, Fidler TP, Sebag SC, Rasmussen TP, Mittauer DJ, Strack S, Goswami PC, Abel ED, Grumbach IM. Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation., Science signaling. 2019 April 30;12(579). PMID:31040260. doi: 10.1126/scisignal.aav1439.
  170. Chen H, Ji X, Lee WC, Shi Y, Li B, Abel ED, Jiang D, Huang W, Long F. Increased glycolysis mediates Wnt7b-induced bone formation., FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 July 1;33(7):7810-7821. PMID:30913395. PMCID: PMC6593878. doi: 10.1096/fj.201900201RR.
  171. Hsieh MH, Choe JH, Gadhvi J, Kim YJ, Arguez MA, Palmer M, Gerold H, Nowak C, Do H, Mazambani S, Knighton JK, Cha M, Goodwin J, Kang MK, Jeong JY, Lee SY, Faubert B, Xuan Z, Abel ED, Scafoglio C, Shackelford DB, Minna JD, Singh PK, Shulaev V, Bleris L, Hoyt K, Kim J, Inoue M, DeBerardinis RJ, Kim TH, Kim JW. p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas., Cell reports. 2019 August 13;28(7):1860-1878.e9. PMID:31412252. doi: 10.1016/j.celrep.2019.07.027.
  172. Li K, Li M, Li W, Yu H, Sun X, Zhang Q, Li Y, Li X, Li Y, Abel ED, Wu Q, Chen H. Airway epithelial regeneration requires autophagy and glucose metabolism., Cell death & disease. 2019 November 20;10(12):875. PMID:31748541. PMCID: PMC6868131. doi: 10.1038/s41419-019-2111-2.
  173. Li X, Wu J, Sun X, Wu Q, Li Y, Li K, Zhang Q, Li Y, Abel ED, Chen H. Autophagy Reprograms Alveolar Progenitor Cell Metabolism in Response to Lung Injury., Stem cell reports. 2020 January 28. PMID:32059792. doi: 10.1016/j.stemcr.2020.01.008.
  174. Shanmugam G, Wang D, Gounder SS, Fernandes J, Litovsky SH, Whitehead K, Radhakrishnan RK, Franklin S, Hoidal J, Kensler TW, Dell'Italia L, Darley-Usmar V, Abel ED, Jones DP, Ping P, Namakkal Soorappan R. Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction., Antioxidants & redox signaling. 2020 February 16. PMID:32064894. doi: 10.1089/ars.2019.7808.
  175. Riehle C, Weatherford ET, Wende AR, Jaishy BP, Seei AW, McCarty NS, Rech M, Shi Q, Reddy GR, Kutschke WJ, Oliveira K, Pires KM, Anderson JC, Diakos NA, Weiss RM, White MF, Drakos SG, Xiang YK, Abel ED. Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling., JCI insight. 2020 March 26;5(6). PMID:32213702. doi: 10.1172/jci.insight.134920.
  176. Ponce JM, Coen G, Spitler KM, Dragisic N, Martins I, A Hinton, Jr, Mungai M, Tadinada SM, Zhang H, Oudit GY, Song LS, Li N, Sicinski P, Strack S, Abel ED, Mitchell C, Hall DD, Grueter CE. Stress-Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics., Journal of the American Heart Association. 2020 April 7;9(7):e014366. PMID:32248761. doi: 10.1161/JAHA.119.014366.
  177. Badolia R, Ramadurai DKA, Abel ED, Ferrin P, Taleb I, Shankar TS, Thodou Krokidi A, Navankasattusas S, McKellar SH, Yin M, Kfoury AG, Wever-Pinzon O, Fang JC, Selzman CH, Chaudhuri D, Rutter J, Drakos SG. The Role of Non-Glycolytic Glucose Metabolism in Myocardial Recovery upon Mechanical Unloading and Circulatory Support in Chronic Heart Failure., Circulation. 2020 April 30. PMID:32351122. doi: 10.1161/CIRCULATIONAHA.119.044452.
  178. Wende AR, Schell JC, Ha CM, Pepin ME, Khalimonchuk O, Schwertz H, Pereira RO, Brahma MK, Tuinei J, Contreras-Ferrat A, Wang L, Andrizzi CA, Olsen CD, Bradley WE, Dell'Italia LJ, Dillmann WH, Litwin SE, Abel ED. Maintaining Myocardial Glucose Utilization in Diabetic Cardiomyopathy Accelerates Mitochondrial Dysfunction., Diabetes. 2020 May 4. PMID:32366681. doi: 10.2337/db19-1057.
  179. Veys K, Fan Z, Ghobrial M, Bouché A, García-Caballero M, Vriens K, Conchinha NV, Seuwen A, Schlegel F, Gorski T, Crabbé M, Gilardoni P, Ardicoglu R, Schaffenrath J, Casteels C, De Smet G, Smolders I, Van Laere K, Abel ED, Fendt SM, Schroeter A, Kalucka J, Cantelmo AR, Wälchli T, Keller A, Carmeliet P, De Bock K. Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity., Circulation research. 2020 May 14. PMID:32404031. doi: 10.1161/CIRCRESAHA.119.316463.
  180. Contat C, Ancey PB, Zangger N, Sabatino S, Pascual J, Escrig S, Jensen L, Goepfert C, Lanz B, Lepore M, Gruetter R, Rossier A, Berezowska S, Neppl C, Zlobec I, Clerc-Rosset S, Knott GW, Rathmell JC, Abel ED,Meibom A, Meylan E. Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth., eLife. 2020 June 23;9. PMID:32571479. PMCID: PMC7311173. doi: 10.7554/eLife.53618.
  181. Li B, Lee WC, Song C, Ye L, Abel ED, Long F. Both aerobic glycolysis and mitochondrial respiration are required for osteoclast differentiation., FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 July 6. PMID:32627870. doi: 10.1096/fj.202000771R.
  182. Brahma MK, Ha CM, Pepin ME, Mia S, Sun Z, Chatham JC, Habegger KM, Abel ED, Paterson AJ, Young ME, Wende AR. Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization., Journal of the American Heart Association. 2020 August 4;9(15):e013039. PMID:32750298. doi: 10.1161/JAHA.119.013039.
  183. Kumar A, Xie L, Ta CM, Hinton  Jnr AO, Gunasekar SK, Minerath RA, Shen K, Maurer JM, Grueter CE, Abel ED, Meyer G, Sah R. SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism., eLife. 2020 September 15;9. PMID:32930093. doi: 10.7554/eLife.58941.
  184. Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton, Jr AO, Guo DF, Weiss R, Bradberry K, Taylor EB, Rauckhorst AJ, Dick DW, Akurathi V, Falls-Hubert KC, Wagner BA, Carter WA, Wang K, Norris AW, Rahmouni K, Buettner GR, Hansen JM, Spitz DR, Abel ED, Sheffield VC. Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes., Cell metabolism. 2020 October 6;32(4):561-574.e7. PMID:33027675. doi: 10.1016/j.cmet.2020.09.012.
  185. Zhang Y, Taufalele PV, Cochran JD, Robillard-Frayne I, Marx JM, Soto J, Rauckhorst AJ, Tayyari F, Pewa AD, Gray LR, Teesch LM, Puchalska P, Funari TR, McGlauflin R, Zimmerman K, Kutschke WJ, Cassier T, Hitchcock S, Lin K, Kato KM, Stueve JL, Haff L, Weiss RM, Cox JE, Rutter J, Taylor EB, Crawford PA, Lewandowski ED, Des Rosiers C, Abel ED. Mitochondrial pyruvate carriers are required for myocardial stress adaptation., Nature metabolism. 2020 October 26. PMID:33106689. doi: 10.1038/s42255-020-00288-1.
  186. Tang M, Park SH, Petri S, Yu H, Rueda CB, Abel ED, Kim CY, Hillman EMC, Li F, Lee Y, Ding L, Jagadish S, Frankel WN, De Vivo DC, Monani UR. An early endothelial cell-specific requirement for Glut1 is revealed in Glut1 deficiency syndrome model mice., JCI insight. 2020 December 22. PMID:33351789. doi: 10.1172/jci.insight.145789.
  187. Weeks KL, Tham YK, Yildiz SG, Alexander Y, Donner DG, Kiriazis H, Harmawan CA, Hsu AT, Bernardo BC, Matsumoto A, DePinho RA, Abel ED, Woodcock EA, McMullen JR. FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K., American journal of physiology. Heart and circulatory physiology. 2021 February 12. PMID:33577435. doi: 10.1152/ajpheart.00838.2020.
  188. Ancey PB, Contat C, Boivin G, Sabatino S, Pascual J, Zangger N, Perentes JY, Peters S, Abel ED, Kirsch DG, Rathmell JC, Vozenin MC, Meylan E. Glut1 expression in tumor-associated neutrophils promotes lung cancer growth and resistance to radiotherapy., Cancer research. 2021 March 22. PMID:33753374. doi: 10.1158/0008-5472.CAN-20-2870.
  189. Pereira RO, Marti A, Olvera AC, Tadinada SM, Bjorkman SH, Weatherford ET, Morgan DA, Westphal M, Patel PH, Kirby AK, Hewezi R, Bùi Trân W, García-Peña LM, Souvenir RA, Mittal M, Adams CM, Rahmouni K, Potthoff MJ, Abel ED. OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21., eLife. 2021 May 4;10. PMID:33944779. PMCID: PMC8128440. doi: 10.7554/eLife.66519.
  190. Bhardwaj G, Penniman CM, Jena J, Suarez Beltran PA, Foster C, Poro K, Junck TL, Hinton, Jr AO, Souvenir R, Fuqua JD, Morales PE, Bravo-Sagua R, Sivitz WI, Lira VA, Abel ED, O'Neill BT. Insulin and IGF-1 receptors regulate complex-I dependent mitochondrial bioenergetics and supercomplexes via FoxOs in muscle., The Journal of clinical investigation. 2021 August 3. PMID:34343133. doi: 10.1172/JCI146415.
  191. Lam J, Katti P, Biete M, Mungai M, AshShareef S, Neikirk K, Garza Lopez E, Vue Z, Christensen TA, Beasley HK, Rodman TA, Murray SA, Salisbury JL, Glancy B, Shao J, Pereira RO, Abel ED, A Hinton, Jr. A Universal Approach to Analyzing Transmission Electron Microscopy with ImageJ., Cells. 2021 August 24;10(9). PMID:34571826. PMCID: PMC8465115. doi: 10.3390/cells10092177.
  192. Tadinada SM, Weatherford ET, Collins GV, Bhardwaj G, Cochran J, Kutschke W, Zimmerman K, Bosko A, O'Neill BT, Weiss RM, Abel ED. FUNCTIONAL RESILIENCE OF C57BL/6J MOUSE HEART TO DIETARY FAT OVERLOAD., American journal of physiology. Heart and circulatory physiology. 2021 September 3. PMID:34477461. doi: 10.1152/ajpheart.00419.2021.
  193. Morales PE, Monsalves-Álvarez M, Tadinada SM, Harris MP, Ramírez-Sagredo A, Ortiz-Quintero J, Troncoso MF, De Gregorio N, Calle X, Pereira RO, Lira VA, Espinosa A, Abel ED, Lavandero S. Skeletal muscle type-specific mitochondrial adaptation to high-fat diet relies on differential autophagy modulation., FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021 October 1;35(10):e21933. PMID:34555201. doi: 10.1096/fj.202001593RR.
  194. Wang J, Ciampa G, Zheng D, Shi Q, Chen B, Abel ED, Peng T, Hall DD, Song LS. Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy., The Biochemical journal. 2021 October 15;478(19):3539-3553. PMID:34524407. doi: 10.1042/BCJ20210629.
  195. Harris MP, Zhang QJ, Cochran CT, Ponce J, Alexander S, Kronemberger A, Fuqua JD, Zhang Y, Fattal R, Harper T, Murry ML, Grueter CE, Abel ED, Lira VA. Perinatal versus adult loss of ULK1 and ULK2 distinctly influences cardiac autophagy and function. 2022: Autophagy. 2022 Feb 1:1-17. doi: 10.1080/15548627.2021.2022289. Online ahead of print. 
  196. Garza Lopez E, Vue Z, Katti P, Neikirk K, Biete M, Lam J, Beasley HK, Marshall A, Rodman TA, Christensen TA, Salisbury JL, Vang L, Mungai M, AshShareef S, Murray SA, Shao J, Streeter J, Glancy B, Pereira RO, Abel ED, Hinton A, Jr. Practices for Measuring 3D Organelle Morphology and Generating Surfaces with Amira. 2022:Cells. 2022; 11(1):65. https://doi.org/10.3390/cells11010065
  197. Matsuura Y, Shimizu-Albergine M , Barnhart S, Kramer F, Hsu C-C, Kothari V,Tang J, Gharib SA, Kanter JE , Abel ED, Tian R , Shao B, Bornfeldt KE. Diabetes Suppresses Glucose Uptake and Glycolysis in Macrophages. 2022. Circulation Research. 130(5):779-781. doi: 10.1161/CIRCRESAHA.121.320060.
  198. Hochrein SM, Wu H, Eckstein M, Arrigoni L, Herman JS, Schumacher F, Gerecke C, Rosenfeldt M, Grün D, Kleuser B, Gasteiger G, Kastenmüller W, Ghesquière B, Van den Bossche J, Abel ED, Vaeth M. The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming. 2022. Cell Metab. 34:516-532.e11. doi: 10.1016/j.cmet.2022.02.015.
  199. Bugger, H., Byrne, N.J., & Abel, E.D. (2022). Animal Models of Dysregulated Cardiac Metabolism. Circulation research, 130(12), 1965-1993. https://doi.org/10.1161/CIRCRESAHA.122.320334
  200. Felker, G. M., Buttrick, P., Rosenzweig, A., Abel, E. D., Allen, L. A., Bristow, M., Das, S., DeVore, A. D., Drakos, S. G., Fang, J. C., Freedman, J. E., Hernandez, A. F., Li, D. Y., McKinsey, T. A., Newton-Cheh, C., Rogers, J. G., Shah, R. V., Shah, S. H., Stehlik, J., & Selzman, C. H. (2022). Heart Failure Strategically Focused Research Network: Summary of Results and Future Directions. Journal of the American Heart Association, 11(18), e025517. https://doi.org/10.1161/JAHA.122.025517
  201. Yoon JY, Daneshgar N, Chuy Y, Chen B, Hefti M, Irani K, Song LS, Brenner C, Abel ED, London B, Dai DF. Metabolic rescue ameliorates mitochondrial encephalo-cardiomyopathy in murine and human iPSC models of Leigh syndrome. 2022: Clinical and Translational Medicine. 12(7):e954. doi: 10.1002/ctm2.954. PMC9309541
  202. Riehle C, Weatherford ET, McCarty NS, Seei A, Jaishy BP, Manivel R, Galuppo P, Allamargot C, Hameed T, Boudreau RL, Bauersachs J, Weiss RM, Abel ED. Insulin and Insulin-Like Growth Factor 1 Signaling Preserves Sarcomere Integrity in the Adult Heart. Mol Cell Biol. 2022 Sep 20:e0016322. doi: 10.1128/mcb.00163-22. Online ahead of print.
  203. Pereira, R. O., Olvera, A. C., Marti, A., Fang, S., White, J. R., Westphal, M., Hewezi, R., AshShareef, S. T., Pena, L., Koneru, J., Potthoff, M. J., & Abel, E. D. (2022). OPA1 Regulates Lipid Metabolism and Cold-Induced Browning of White Adipose Tissue in Mice. Diabetes, db220450. Advance online publication. https://doi.org/10.2337/db22-0450
  204. Sonkar, V. K., Eustes, A. S., Ahmed, A., Jensen, M., Solanki, M. V., Swamy, J., Kumar, R., Fidler, T. P., Houtman, J. C. D., Allen, B. G., Spitz, D. R., Abel, E. D., & Dayal, S. (2023). Endogenous SOD2 (Superoxide Dismutase) Regulates Platelet-Dependent Thrombin Generation and Thrombosis During Aging. Arteriosclerosis, thrombosis, and vascular biology, 43(1), 79–91. https://doi.org/10.1161/ATVBAHA.121.317735
  205. Naasner, L., Froese, N., Hofmann, W., Galuppo, P., Werlein, C., Shymotiuk, I., Szaroszyk, M., Erschow, S., Amanakis, G., Bähre, H., Kühnel, M. P., Jonigk, D. D., Geffers, R., Seifert, R., Ricke-Hoch, M., Wende, A. R., Blaner, W. S., Abel, E. D., Bauersachs, J., & Riehle, C. (2022). Vitamin A preserves cardiac energetic gene expression in a murine model of diet-induced obesity. American journal of physiology. Heart and circulatory physiology, 323(6), H1352–H1364. https://doi.org/10.1152/ajpheart.00514.2022
  206. McMillin, S. L., Evans, P. L., Taylor, W. M., Weyrauch, L. A., Sermersheim, T. J., Welc, S. S., Heitmeier, M. R., Hresko, R. C., Hruz, P. W., Koumanov, F., Holman, G. D., Abel, E. D., & Witczak, C. A. (2022). Muscle-Specific Ablation of Glucose Transporter 1 (GLUT1) Does Not Impair Basal or Overload-Stimulated Skeletal Muscle Glucose Uptake. Biomolecules, 12(12), 1734. https://doi.org/10.3390/biom12121734
  207. Shymotiuk, I., Froese, N., Werlein, C., Naasner, L., Szaroszyk, M., Kühnel, M. P., Jonigk, D. D., Blaner, W. S., Wende, A. R., Abel, E. D., Bauersachs, J., & Riehle, C. (2023). Vitamin A regulates tissue-specific organ remodeling in diet-induced obesity independent of mitochondrial function. Frontiers in endocrinology, 14, 1118751. https://doi.org/10.3389/fendo.2023.1118751
  208. Shymotiuk I, Froese N, Werlein C, Naasner L, Szaroszyk M, Kühnel MP, Jonigk DD, Blaner WS, Wende AR, Abel ED, Bauersachs J, Riehle C. Vitamin A regulates tissue-specific organ remodeling in diet-induced obesity independent of mitochondrial function. Front Endocrinol (Lausanne). 2023 Feb 20;14:1118751. doi: 10.3389/fendo.2023.1118751. PMID: 36891060; PMCID: PMC9987331.
  209. Jovanovic A, Xu B, Zhu C, Ren D, Wang H, Krause-Hauch M, Abel ED, Li J, Xiang YK. Characterizing Adrenergic Regulation of Glucose Transporter 4-Mediated Glucose Uptake and Metabolism in the Heart. JACC Basic Transl Sci. 2023 Feb 22;8(6):638-655. doi: 10.1016/j.jacbts.2022.11.008. PMID: 37426525; PMCID: PMC10322917.
  210. Neikirk K, Vue Z, Katti P, Rodriguez BI, Omer S, Shao J, Christensen T, Garza Lopez E, Marshall A, Palavicino-Maggio CB, Ponce J, Alghanem AF, Vang L, Barongan T, Beasley HK, Rodman T, Stephens D, Mungai M, Correia M, Exil V, Damo S, Murray SA, Crabtree A, Glancy B, Pereira RO, Abel ED, Hinton AO Jr. Systematic Transmission Electron Microscopy-Based Identification and 3D Reconstruction of Cellular Degradation Machinery. Adv Biol (Weinh). 2023 Mar 3:e2200221. doi: 10.1002/adbi.202200221. Epub ahead of print. PMID: 36869426. 
  211. Amorese AJ, Minchew EC, Tarpey MD, Readyoff AT, Williamson NC, Schmidt CA, McMillin SL, Goldberg EJ, Terwilliger ZS, Spangenburg QA, Witczak CA, Brault JJ, Abel ED, McClung JM, Fisher-Wellman KH, Spangenburg EE. Hypoxia Resistance Is an Inherent Phenotype of the Mouse Flexor Digitorum Brevis Skeletal Muscle. Function (Oxf). 2023 Mar 21;4(3):zqad012. doi: 10.1093/function/zqad012. PMID: 37168496; PMCID: PMC10165545.
  212. Hinton A Jr, Katti P, Christensen TA, Mungai M, Shao J, Zhang L, Trushin S, Alghanem A, Jaspersen A, Geroux RE, Neikirk K, Biete M, Lopez EG, Shao B, Vue Z, Vang L, Beasley HK, Marshall AG, Stephens D, Damo S, Ponce J, Bleck CKE, Hicsasmaz I, Murray SA, Edmonds RAC, Dajles A, Koo YD, Bacevac S, Salisbury JL, Pereira RO, Glancy B, Trushina E, Abel ED. A Comprehensive Approach to Sample Preparation for Electron Microscopy and the Assessment of Mitochondrial Morphology in Tissue and Cultured Cells. Adv Biol (Weinh). 2023 May 4:e2200202. doi: 10.1002/adbi.202200202. Epub ahead of print. PMID: 37140138.
  213. Yurista SR, Chen S, Eder RA, Garrett T, Butsch WS, Aminian A, Tang WHW, Farrar CT, Gee D, Abel ED, Das S, Nguyen CT. Mapping the Unseen: In Vivo CEST-MRI of Creatine Reveals Improved Cardiac Energetics in Subjects with Obesity Following Bariatric Surgery. Obes Surg. 2023 Jun;33(6):1944-1948. doi: 10.1007/s11695-023-06589-0. Epub 2023 Apr 14. PMID: 37058265.
  214. Abel ED, Giffin J, Ingelfinger JR, Peek M, Reusch JEB, Rosen CJ, Sagendorf A, Thomas E Sr. Type 2 Diabetes - Controlling the Epidemic, Episode 1: Understanding and Preventing Type 2 Diabetes. N Engl J Med. 2023 Sep 7;389(10):e18. doi: 10.1056/NEJMp2308230. PMID: 37672693.
  215. Yu DM, Zhao J, Lee EE, Kim D, Mahapatra R, Rose EK, Zhou Z, Hosler CR, El-Kurdi A, Choe JY, Abel ED, Hoxhaj G, Westover KD, Cho RJ, Cheng JB, Wang RC. GLUT3 promotes macrtophage signaling and function via Ras-mediated endocytosis in atopic dermatitis and wound healing. J Clin Invest. 2023 Sep 14:e170706. doi: 10.1172/JCI70706. Epub ahead of print. PMID: 37721853.
  216. Abel ED, Ingelfinger JR, Kolko J, Linhales Barker S, Lopez D, Mejia M, Peek M, Reusch JEB, Rosen CJ. Type 2 Diabetes - Controlling the Epidemic, Episode 2: After the Diagnosis - Making a Plan and Addressing Social Determinants of Health. N Engl J Med. 2023 Sep 21;389(12):e23. doi: 10.1056/NEJMp2308232. PMID: 37733307.
  217. Jena J, García-Peña LM, Weatherford ET, Marti A, Bjorkman SH, Kato K, Koneru J, Chen JH, Seeley RJ, Abel ED, Pereira RO. GDF15 is required for cold-induced thermogenesis and contributes to improved systemic metabolic health following loss of OPA1 in brown adipocytes. Elife. 2023 Oct 11;12:e86452. doi: 10.7554/eLife.86452. PMID: 37819027; PMCID: PMC10567111.
  218. Jacob S, Kosaka Y, Bhatlekar S, Denorme F, Benzon H, Moody A, Moody V, Tugolukova EA, Hull G, Kishimoto N, Manne BK, Guo L, Souvenir R, Seliger BJ, Eustes AS, Hoerger K, Tolley ND, Fatahian AN, Boudina S, Christiani DC, Wei Y, Ju C, Campbell RA, Rondina MT, Abel ED, Bray PF, Weyrich AS, Rowley JW. Mitofusin-2 Regulates Platelet Mitochondria and Function. Circ Res. 2024 Jan 19;134(2):143-161. doi: 10.1161/CIRCRESAHA.123.322914. Epub 2023 Dec 29. PMID: 38156445; PMCID: PMC10872864.
  219. Zhang Q, Li Z, Li Q, Trammell SA, Schmidt MS, Pires KM, Cai J, Zhang Y, Kenny H, Boudina S, Brenner C, Abel ED. Control of NAD+ homeostasis by autophagic flux modulates mitochondrial and cardiac function. EMBO J. 2024 Feb;43(3):362-390. doi: 10.1038/s44318-023-00009-w. Epub 2024 Jan 11. PMID: 38212381; PMCID: PMC10897141.
  220. Froese N, Szaroszyk M, Galuppo P, Visker JR, Werlein C, Korf-Klingebiel M, Berliner D, Reboll MR, Hamouche R, Gegel S, Wang Y, Hofmann W, Tang M, Geffers R, Wende AR, Kühnel MP, Jonigk DD, Hansmann G, Wollert KC, Abel ED, Drakos SG, Bauersachs J, Riehle C. Hypoxia Attenuates Pressure Overload-Induced Heart Failure. J Am Heart Assoc. 2024 Feb 6;13(3):e033553. doi: 10.1161/JAHA.123.033553. Epub 2024 Jan 31. PMID: 38293923; PMCID: PMC11056135.
  221. García-Peña LM, Abel ED, Pereira RO. Mitochondrial Dynamics, Diabetes, and Cardiovascular Disease. Diabetes. 2024 Feb 1;73(2):151-161. doi: 10.2337/dbi23-0003. PMID: 38241507; PMCID: PMC10796300.
  222. Hinton A Jr, Katti P, Mungai M, Hall DD, Koval O, Shao J, Vue Z, Lopez EG, Rostami R, Neikirk K, Ponce J, Streeter J, Schickling B, Bacevac S, Grueter C, Marshall A, Beasley HK, Do Koo Y, Bodine SC, Nava NGR, Quintana AM, Song LS, Grumbach IM, Pereira RO, Glancy B, Abel ED. ATF4-dependent increase in mitochondrial-endoplasmic reticulum tethering following OPA1 deletion in skeletal muscle. J Cell Physiol. 2024 Apr;239(4):e31204. doi: 10.1002/jcp.31204. Epub 2024 Feb 28. PMID: 38419397.
  223. Shi Q, Malik H, Crawford RM, Streeter J, Wang J, Huo R, Shih JC, Chen B, Hall D, Abel ED, Song LS, Anderson EJ. Cardiac monoamine oxidase-A inhibition protects against catecholamine-induced ventricular arrhythmias via enhanced diastolic calcium control. Cardiovasc Res. 2024 May 7;120(6):596-611. doi: 10.1093/cvr/cvae012. PMID: 38198753; PMCID: PMC11074799.
  224. Devarajan A, Wang K, Lokhandwala ZA, Emamimeybodi M, Shannon K, Tompkins JD, Hevener AL, Lusis AJ, Abel ED, Vaseghi M. Myocardial infarction causes sex-dependent dysfunction in vagal sensory glutamatergic neurotransmission that is mitigated by 17β-Estradiol. JCI Insight. 2024 Jun 11:e181042. doi: 10.1172/jci.insight.181042. Epub ahead of print. PMID: 38885308.
  225. Abel ED, Gloyn AL, Evans-Molina C, Joseph JJ, Misra S, Pajvani UB, Simcox J, Susztak K, Drucker DJ. Diabetes mellitus-Progress and opportunities in the evolving epidemic. Cell. 2024 Jul 25;187(15):3789-3820. doi: 10.1016/j.cell.2024.06.029. PMID: 39059357.