Recent Publications from UCLA Obstetrics and Gynecology
Severe COVID-19 in pregnancy has a distinct serum profile, including greater complement activation and dysregulation of serum lipids. Altendahl M, Mok T, Jang C, Yeo S, Quach A, Afshar Y. PLoS One. 2022 Nov 16;17(11):e0276766. doi: 10.1371/journal.pone.0276766. PMID: 36383608.
Emergent Prelabor Cesarean Birth in Solid Organ Transplant Recipients: Associated Risk Factors and Outcomes. Chung K, Yin O, Kallapur A, Bass L, Coscia L, Constantinescu S, Moritz M, Afshar Y. Am J Obstet Gynecol MFM. 2022 Nov 8:100799. doi: 10.1016/j.ajogmf.2022.100799. Epub ahead of print. PMID: 36368514.
Development of delivery plans for women with complex heart disease. Canobbio M, Afshar Y. International Journal of Cardiology Congenital Heart Disease. 2022. doi.org/10.1016/j.ijcchd.2022.100375.Epub 23 April 2022. Published Ahead of Print
Pregnant and pulmonary hypertension: from preconception and risk stratification through pregnancy and postpartum. Mei J, Channick R, Afshar Y. Heart Failure Clinics, In Press.
Guidance for fetal cardiac imaging in patients with degraded acoustic windows.Sklansky M, Afshar Y, Anton T, DeVore GR, Platt L, Satou G. Ultrasound Obstet Gynecol. 2022 Feb 3. doi: 10.1002/uog.24872. Epub ahead of print. PMID: 35118748.
Randomized clinical trial: effect of low-dose flutamide on abdominal adipogenic function in normal-weight women with polycystic ovary syndrome. Dumesic DA, Winnett C, Lu G, Grogan TR, Abbott DH, Naik R, Chazenbalk GD. Fertil Steril. 2022 Nov 15:S0015-0282(22)01745-9. doi: 10.1016/j.fertnstert.2022.09.324. Epub ahead of print. PMID: 36400597.
A randomized controlled trial of a shared decision making intervention for diabetes prevention for women with a history of gestational diabetes mellitus: The Gestational diabetes Risk Attenuation for New Diabetes (GRAND study). Madievsky R, Vu A, Cheng F, Chon J, Turk N, Krueger A, Krong J, Maranon R, Liu S, Han CS, Norris KC, Mangione C, Page J, Thomas S, Duru OK, Moin T. Contemp Clin Trials. 2022 Nov 13;124:107007. doi: 10.1016/j.cct.2022.107007. Epub ahead of print. PMID: 36384219.
A Description of the Imaging Innovations for Placental Assessment in Response to Environmental Pollution Study. Janzen C, Lei MYY, Lee BR, Vangala S, DelRosario I, Meng Q, Ritz B, Liu J, Jerrett M, Chanlaw T, Choi S, Aliabadi A, Fortes PA, Sullivan PS, Murphy A, Vecchio GD, Thamotharan S, Sung K, Devaskar SU. Am J Perinatol. 2022 Dec 5. doi: 10.1055/a-1961-2059. Epub ahead of print. PMID: 36241211.
Circulating extracellular vesicles exhibit a differential miRNA profile in gestational diabetes mellitus pregnancies. Thamotharan S, Ghosh S, James-Allan L, Lei MYY, Janzen C, Devaskar SU. PLoS One. 2022 May 25;17(5):e0267564. doi: 10.1371/journal.pone.0267564. PMID: 35613088; PMCID: PMC9132306.
Gene expression profiling of mucinous ovarian tumors and comparison with upper and lower gastrointestinal tumors identifies markers associated with adverse outcomes. Meagher NS, Gorringe KL, Wakefield MJ…Karlan BY…Pharoah PDP, Anderson L, DeFazio A, Köbel M, Friedlander ML, Ramus SJ.Clin Cancer Res. 2022 Oct 12:CCR-22-1206. doi: 10.1158/1078-0432.CCR-22-1206. Online ahead of print.PMID: 36222710
Copy Number Variants Are Ovarian Cancer Risk Alleles at Known and Novel Risk Loci. DeVries AA, Dennis J, Tyrer JP, Peng PC…Karlan BY…Pharoah PDP, Easton DF, Gayther SA, Jones MR.J Natl Cancer Inst. 2022 Oct 10:djac160. doi: 10.1093/jnci/djac160. Online ahead of print.PMID: 36210504
Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers. Hakkaart C, Pearson JF, Marquart L, Dennis J…Karlan BY…Chenevix-Trench G, Spurdle AB, Antoniou AC, Walker LC.Commun Biol. 2022 Oct 6;5(1):1061. doi: 10.1038/s42003-022-03978-6.PMID: 36203093
Molecular Analysis of Short- versus Long-Term Survivors of High-Grade Serous Ovarian Carcinoma. Stur E, Bayraktar E, Dal Molin GZ, Wu SY…Karlan BY, Sood AK.Cancers (Basel). 2022 Aug 30;14(17):4198. doi: 10.3390/cancers14174198.PMID: 36077735
DNA methylation and transcriptomic features are preserved throughout disease recurrence and chemoresistance in high grade serous ovarian cancers. Gull N, Jones MR, Peng PC, Coetzee SG…Karlan BY, Gayther SA.J Exp Clin Cancer Res. 2022 Jul 27;41(1):232. doi: 10.1186/s13046-022-02440-z.PMID: 35883104
Molecular subclasses of clear cell ovarian carcinoma and their impact on disease behavior and outcomes. Bolton KL, Chen D, Corona de la Fuente RI, Fu Z…Karlan BY…Gayther SA, Konner J, Modugno F, Lawrenson K, Goode EL, Papaemmanuil E.Clin Cancer Res. 2022 Jul 11:ccr.21.3817. doi: 10.1158/1078-0432.CCR-21-3817. Online ahead of print.PMID: 35816189
Frailty is independently associated with worse outcomes and increased resource utilization following endometrial cancer surgery. Nakhla M, Eakin CM, Mandelbaum A, Karlan BY, Benharash P, Salani R, Cohen JG.Int J Gynecol Cancer. 2022 Jun 20:ijgc-2022-003484. doi: 10.1136/ijgc-2022-003484. Online ahead of print.PMID: 35725031
A multi-level investigation of the genetic relationship between endometriosis and ovarian cancer histotypes. Mortlock S, Corona RI, Kho PF, Pharoah P…Karlan BY, Rimel BJ; Ovarian Cancer Association Consortium, International Endometriosis Genetics Consortium, Montgomery GW, Lawrenson K, Kar SP.Cell Rep Med. 2022 Mar 15;3(3):100542. doi: 10.1016/j.xcrm.2022.100542. eCollection 2022 Mar 15.PMID: 35492879
Bilateral Oophorectomy and the Risk of Breast Cancer in BRCA1 Mutation Carriers: A Reappraisal. Kotsopoulos J, Lubinski J, Gronwald J, Menkiszak J…Karlan BY…Pal T, Sun P, Narod SA.Cancer Epidemiol Biomarkers Prev. 2022 Jul 1;31(7):1351-1358. doi: 10.1158/1055-9965.EPI-21-1196.PMID: 35477169
CA-125 Levels Are Predictive of Survival in Low-Grade Serous Ovarian Cancer-A Multicenter Analysis. Wohlmuth C, Djedovic V, Kjaer SK, Jensen A…Karlan BY…Lajkosz K, Tone A, May T. Cancers (Basel). 2022 Apr 13;14(8):1954. doi: 10.3390/cancers14081954.PMID: 35454861
Intervertebral disc degeneration is rescued by TGFβ/BMP signaling modulation in an ex vivo filamin B mouse model. Zieba J, Forlenza KN, Heard K, Martin JH, Bosakova M, Cohn DH, Robertson SP, Krejci P, Krakow D. Bone Res. 2022 Apr 26;10(1):37. doi: 10.1038/s41413-022-00200-5. PMID: 35474298; PMCID: PMC9042866.
Alarming trends and disparities in high-risk endometrial cancer. Eakin CM, Lai T, Cohen JG. Curr Opin Obstet Gynecol. 2022 Oct 14. doi: 10.1097/GCO.0000000000000832. Epub ahead of print. PMID: 36239552.
Expression of immune checkpoint regulators, programmed death-ligand 1 (PD-L1/PD-1), cytotoxic T lymphocyte antigen 4 (CTLA-4), and indolaimine-2, 3-deoxygenase (IDO) in uterine mesenchymal tumors. Samiei A, Gjertson DW, Memarzadeh S, Konecny GE, Moatamed NA. Diagn Pathol. 2022 Sep 14;17(1):70. doi: 10.1186/s13000-022-01251-2. PMID: 36104728; PMCID: PMC9476344.
Delivery Timing and Associated Outcomes in Pregnancies with Maternal Congenital Heart Disease at Term. Mok T, Woods A, Small A, Canobbio MM, Tandel MD, Kwan L, Lluri G, Reardon L, Aboulhosn J, Lin J, Afshar Y. J Am Heart Assoc. 2022 Aug 9:e025791. doi: 10.1161/JAHA.122.025791. Epub ahead of print. PMID: 35943056.
Ovarian cancer cell fate regulation by the dynamics between saturated and unsaturated fatty acids. Zhao G, Tan Y, Cardenas H, Vayngart D, Wang Y, Huang H, Keathley R, Wei JJ, Ferreira CR, Orsulic S, Cheng JX, Matei D. Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2203480119. doi: 10.1073/pnas.2203480119. Epub 2022 Oct 5.PMID: 36197994.
Computational pathology in ovarian cancer. Orsulic S, John J, Walts AE, Gertych A. Front Oncol. 2022 Jul 29;12:924945. doi: 10.3389/fonc.2022.924945. eCollection 2022.PMID: 35965569 Free PMC article. Review.
Focal Serous Tubal Intra-Epithelial Carcinoma Lesions Are Associated With Global Changes in the Fallopian Tube Epithelia and Stroma. Wu J, Raz Y, Recouvreux MS, Diniz MA, Lester J, Karlan BY, Walts AE, Gertych A, Orsulic S. Front Oncol. 2022 Mar 21;12:853755. doi: 10.3389/fonc.2022.853755. eCollection 2022.PMID: 35387127 Free PMC article.
Effects of oral contraceptive pills on mood and magnetic resonance imaging measures of prefrontal cortical thickness. London E, Petersen N, Kearly N, Ghahremani D, Pochon J, Fry M, Rapkin A. Mol Psychiatry. 2021 Mar;26(3):917-926. doi: 10.1038/s41380-020-00990-2. Epub 2021 Jan 8. PMID: 33420480
Ecological Momentary Assessment of Non-Menstrual Pelvic Pain; Potential Pathways of Central Sensitization in Adolescent and Young Adults with and without Primary Dysmenorrhea. Seidman L, Temme C, Zeltzer L, Rapkin A, Nailboff B, Payne L. J Pain Res. 2020 Dec 22;13:3447-3456. Doi:10.2147/JPR.S283363. eCollection 2020. PMID; 33376390.
Dysregulation in sphingolipid signaling pathways is associated with symptoms and functional connectivity of pain processing brain regions in provoked vestibulodynia. Labus J, Mayer E, Tillisch K, Aagaard K, Stains J, Broniowska K, Van Remortol C, Guistinna T, Rapkin A. Journal of Pain. 2021 May 21:S1526-5900(21)00231-5. doi: 10.1016/j.jpain.2021.04.017. Epub ahead of print. PMID: 34029688.
Reduced concentrations of vaginal metabolites involved in steroid hormone biosynthesis are associated with increased vulvar vestibular pain and vaginal muscle tenderness in provoked vestibulodynia: An exploratory metabolomics study. Labus J, Mayer E, Aagaard K, Stains J, Broniowska K, Rapkin A. Mol Pain. 2021 Jan-Dec;17:17448069211041853. doi: 10.1177/17448069211041853. PMID: 34505814
Symptom-associated alterations in functional connectivity in primary and secondary provoked vestibulodynia. Oughourlian T, Guistinna T, Antony K, Gupta A, Mays V, Mayer E, Rapkin A, Labus J. Pain. 2022 Aug 15. doi: 10.1097/j.pain.0000000000002754. Online ahead of print. PMID: 35972459
Rational and design of a multicenter randomized clinical trial of vestibulodynia: understanding pathophysiology and determining appropriate treatments (vestibulodynia, UPDATe). Carey E, Geller E, Rapkin A, Farb D, Cutting H, Akaninwor J, Stirling C, Borstov A, McNulty S, Morrill P, Zakroysky P, DeLaRosa J, Luo S, Nackley A. Pregnancy, Childbirth Women's Health. 21 Oct 2022. https://doi.org/10.1080/07853890.2022.2132531
Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination. Matsui Y, Li L, Prahl M, Cassidy AG, Ozarslan N, Golan Y, Gonzalez VJ, Lin CY, Jigmeddagva U, Chidboy MA, Montano M, Taha TY, Khalid MM, Sreekumar B, Hayashi JM, Chen PY, Kumar GR, Warrier L, Wu AH, Song D, Jegatheesan P, Rai DS, Govindaswami B, Needens JM, Rincon M, Myatt L, Asiodu IV, Flaherman VJ, Afshar Y, Jacoby VL, Murtha AP, Robinson JF, Ott M, Greene WC, Gaw SL. JCI Insight. 2022 May 17:e157354. doi: 10.1172/jci.insight.157354. Epub ahead of print. PMID: 35579965.
Clinical risk factors of adverse outcomes among women with COVID-19 in the pregnancy and postpartum period: A sequential, prospective meta-analysis. Smith ER, Oakley E, Grandner GW, Rukundo G, Farooq F, Ferguson K, Baumann S, Waldorf KA, Afshar Y, Ahlberg M, Ahmadzia H, Akelo V, Aldrovandi G, Bevilacqua E, Bracero N, Brandt JS, Broutet N, Carrillo J, Conry J, Cosmi E, Crispi F, Crovetto F, Gil MDM, Delgado-López C, Divakar H, Driscoll AJ, Favre G, Buhigas IF, Flaherman V, Gale C, Godwin CL, Gottlieb S, Gratacós E, He S, Hernandez O, Jones S, Joshi S, Kalafat E, Khagayi S, Knight M, Kotloff K, Lanzone A, Longo VL, Le Doare K, Lees C, Litman E, Lokken EM, Madhi SA, Magee LA, Martinez-Portilla RJ, Metz TD, Miller ES, Money D, Moungmaithong S, Mullins E, Nachega JB, Nunes MC, Onyango D, Panchaud A, Poon LC, Raiten D, Regan L, Sahota D, Sakowicz A, Sanin-Blair J, Stephansson O, Temmerman M, Thorson A, Thwin SS, Tippett Barr BA, Tolosa JE, Tug N, Valencia-Prado M, Visentin S, von Dadelszen P, Whitehead C, Wood M, Yang H, Zavala R, Tielsch JM. Am J Obstet Gynecol. 2022 Aug 23:S0002-9378(22)00680-9. doi: 10.1016/j.ajog.2022.08.038. Epub ahead of print. PMID: 36027953; PMCID: PMC9398561.
Protocol for a sequential, prospective meta-analysis to describe coronavirus disease 2019 (COVID-19) in the pregnancy and postpartum periods. Smith ER, Oakley E, He S, Zavala R, Ferguson K, Miller L, Grandner GW, Abejirinde IO, Afshar Y, Ahmadzia H, Aldrovandi G, Akelo V, Tippett Barr BA, Bevilacqua E, Brandt JS, Broutet N, Fernández Buhigas I, Carrillo J, Clifton R, Conry J, Cosmi E, Delgado-López C, Divakar H, Driscoll AJ, Favre G, Flaherman V, Gale C, Gil MM, Godwin C, Gottlieb S, Hernandez Bellolio O, Kara E, Khagayi S, Kim CR, Knight M, Kotloff K, Lanzone A, Le Doare K, Lees C, Litman E, Lokken EM, Laurita Longo V, Magee LA, Martinez-Portilla RJ, McClure E, Metz TD, Money D, Mullins E, Nachega JB, Panchaud A, Playle R, Poon LC, Raiten D, Regan L, Rukundo G, Sanin-Blair J, Temmerman M, Thorson A, Thwin S, Tolosa JE, Townson J, Valencia-Prado M, Visentin S, von Dadelszen P, Adams Waldorf K, Whitehead C, Yang H, Thorlund K, Tielsch JM. PLoS One. 2022 Jun 16;17(6):e0270150. doi: 10.1371/journal.pone.0270150. PMID: 35709239; PMCID: PMC9202913.
