Flexible 3D ultrasound technology for diagnosis of injuries and intra-operative guidance
The ability to accurately and rapidly diagnosis fractures, shrapnel, wound tracts, and soft tissue injuries are key to effective rapid treatment. Traditional radiographic methods require heavy, bulky X-ray systems that are not suitable for far forward bases or in the field. Current ultrasound systems have shown great promise for diagnosis in the field, but the skill needed for operation and manipulation of the transducer and lack of volumetric data often limit their effectiveness.
We have preliminary evidence that flexible conformable ultrasound arrays for medical imaging are feasible and applicable to the problem of fracture detection in arms, legs, head and neck, as well as detection of shrapnel and wound tracts. These arrays have the advantage of providing multiple unique "looks" around objects and can produce high resolution volumetric images of human extremities in real time. This blood-pressure cuff-type flexible conformable array will allow less experienced personnel to obtain high quality images with minimal manipulation of the affected extremities, since mechanical scanning is not required. These arrays offer the additional advantages of lower power consumption, high portability (laptop based), and durability for battlefield use.
This research project is part of an ongoing collaboration between CASIT and the UC Santa Barbara Department of Electrical and Computer Engineering, the UCLA Department of Bioengineering, the UCLA Department of Surgery, and the UCLA School of Dentistry. This group has previously developed acoustic modeling tools using finite element simulations, transducer fabrication techniques, signal processing algorithms, and testing and characterization methods for various ultrasound applications, ranging from dental ultrasound to minimally invasive surgery.
Funding for this work is provided by the Telemedicine and Advanced Technology Research Center (TATRC) and the Department of Defense (DoD).
Investigators:
Warren Grundfest, MD, UCLA Department of Bioengineering, Surgery, Electrical Engineering
Martin Culjat, PhD, UCLA Department of Surgery
Rahul Singh, PhD, UCSB Department of Electrical and Computer Engineering
Elliott Brown, PhD, UCSB Department of Electrical and Computer Engineering
Hua Lee, PhD, UCSB Department of Electrical and Computer Engineering
Graudate Students: Michael Lee, Shyam Natarajan, Aaron Dann
Undergraduate Students: Johnathan Mai
Publications in Conference and Symposium Proceedings:
- Singh RS, Culjat MO, Vampola SP, Williams K, Taylor ZD, Lee H, Grundfest WS, Brown ER, "Simulation, fabrication, and characterization of a novel flexible, conformal ultrasound transducer array," Proceedings of the 2007 IEEE Ultrasonics Symposium, 28-31 October 2007, New York, NY, 1824-1827, 2007.
- Culjat MO, Singh RS, Utley C, Vampola SP, Sharareh B, Lee H, Brown ER, Grundfest WS, "A flexible, conformal ultrasound array for medical imaging," Proceedings of Medicine Meets Virtual Reality 16: parallel, combinatorial, convergent: NextMed by design, 31 January - 1 February 2008, Long Beach, CA, Studies in Health Technology and Informatics, 132, 95-97, 2008.
- Natarajan S, Singh RS, Lee M, Cox BP, Culjat MO, Lee H, Grundfest WS, "Step-FMCW signaling
and target detection for ultrasound imaging systems with conformal transducer arrays," SPIE
BIOS Biomedical Optics, 23-28 January 2010, San Francisco, CA, 7555, 75550M, 2010. - Natarajan S, Singh RS, Lee M, Cox BP, Culjat MO, Grundfest WS, Lee H, "Accurate step-FMCW
ultrasound ranging and comparison with pulse-echo signaling methods," Proceedings of SPIE
Medical Imaging, 13-18 February 2010, San Diego, CA, 7629, 76290D, 2010. - Lee M, Singh RS, Culjat MO, Stubbs S, Natarajan S, Brown ER, Grundfest WS, Lee H, "Designing
multistatic ultrasound imaging systems using software analysis," Proceedings of SPIE Medical
Imaging, 13-18 February 2010, San Diego, CA, 7629, 76290S, 2010. - Dann AE, Bennett DB, Singh RS, Lemaire JJ, Grundfest WS, Culjat MO, "Fabrication of a
conformal, ring-annular ultrasound array," Proceedings of SPIE Medical Imaging, 13-18
February 2010, San Diego, CA, 7629, 76290R, 2010. - Culjat MO, Goldenberg D, Tewari P, Singh RS, "A review of tissue substitutes for ultrasound
imaging," Ultrasound in Medicine and Biology, 36(6), 861-873, 2010.
Abstracts:
- Culjat MO, Singh RS, White SN, Brown ER, Grundfest W, "A flexible ultrasound array transducer for imaging of the bone-soft tissue interface," 2006 UCLA Engineering Research Review, Los Angeles, CA, 2 May 2006.
- Culjat MO, Singh RS, Tewari P, Bennett DB, Natarajan S, Sharareh B, Lee H, Brown ER, Grundfest WS, "*Flexible conformal ultrasound transducers for imaging of soft and hard tissues*," UCLA Engineering 2008 Technology Forum, 27 May 2008, Los Angeles, CA.
- Culjat M, Singh RS, Utley C, Vampola SP, Lee H, Brown ER, Grundfest WS, "Flexible conformable ultrasound arrays for medical imaging," Medicine Meets Virtual Reality 16: parallel, combinatorial, convergent: NextMed by design, 31 January - 1 February 2008, Long Beach, CA, 2008.
- Sharareh B, Bennett D, Williams K, Singh R, Culjat M, Natarajan S, Tewari P, Lee M, Brown ER, Lee H, Grundfest WS, "*Flexible, Conformal Ultrasound Array for Medical Imaging*," UCLA Engineering 2008 Technology Forum, 27 May 2008, Los Angeles, CA.
- Singh RS, Culjat MO, Vampola SP, Williams K, Grundfest WS, Lee H, Brown ER, "Simulation, fabrication, and characterization of a novel flexible, conformable ultrasound transducer array," 2007 IEEE Ultrasonics Symposium, New York, NY, 28-31 October 2007, Abstract #1245.
- Grundfest W, Culjat M, Singh R, Brown E, "Applications of flexible conformable ultrasound arrays for real-time imaging during neurosurgery," 217th Electrochemical Society Meeting, 27
April 2010, Vancouver, Canada. - Mai J, Natarajan S, Lee M, Dann A, Lee H, Culjat M, Singh RS, Grundfest WS, "Conformal
ultrasound imaging system for transurethral scanning of prostate cancer," 2010 UCLA
Engineering Tech Forum, 11 February 2010, Los Angeles, CA (Abstract)