Translational Pathology Core Laboratory

Overview

The Translational Pathology Core Laboratory (TPCL) shared resource performs human biospecimen procurement/processing, histology services, laser capture microdissection preparation, immunohistochemistry/immunofluorescence, data analysis, and pathology consultation services.

Contact Information

14-127 Center for Health Sciences
University of California, Los Angeles
Los Angeles, CA 90095-1732

Telephone: 310-825-1717
Fax: 310-267-2104
Email: [email protected]
Website: http://pathology.ucla.edu/tpcl

Major Services

1. Human tissue procurement
   • Fresh remnant tissues from surgical resections
   • Clinical trial biospecimen procurement and processing (biopsies, biofluids)
   • Access to archived paraffin blocks
   • CAP accredited human tissue biorepository of frozen/paraffin embedded cancer specimens
2. Histology services
   • Processing, embedding, cutting paraffin/cryostat sections, special stains
   • Both human and animal tissues
3. Laser capture microdissection (sample preparation and training)
4. Immunohistochemistry/immunofluorescence
   • Established antibodies and optimization of new antibodies
   • Multiplexed immunofluorescence staining (up to 9 biomarkers)
5. Digital pathology/image analysis
   • Brightfield/fluorescence whole slide scanning
   • Automated analysis of brightfield/fluorescence images (from any file type)
6. Pathology consultation services
   • Study design, tissue selection, IRB advice, identification of cases within UCLA archives, slide interpretation

Operating Policies

The investigator submits a "Request for Services" form (available by email request); FAU for recharge and (depending on request) IRB approval is also required.

Drs. Ward and French are available to meet with each investigator to assist in "fine-tuning" critical details of the research requirements, optimal tissue sources (e.g., surgery, autopsy), and the method of preparation. Contact Dr. Magyar ([email protected]) to arrange consultations for digital image analysis.

Recharge Rates