Brain-Gut

Brain-gut system in disease and health

Obesity has a complex and multifactorial etiology, and the limited progress in obesity treatments can in large part be attributed to the failure to apply a systems biology-based approach to understand its pathophysiology and to develop individualized strategies directed at sustained weight loss and prevention. A growing body of preclinical literature has demonstrated bidirectional signaling between the brain-gut microbiome (BGM) system. We have shown that behavioral and brain-based differences related to alterations in specific behaviors and disease (e.g. ingestive behaviors and obesity) may also be related to differences in aspects of the microbiome and inflammatory markers that animal studies have demonstrated.

This work has great potential for understanding and revealing the complex interactions between the gut, brain, and microbiota and inflammatory markers.

• An E, Delgadillo DR, Yang J, Agarwal R, Labus JS, Pawar S, Leitman M, Kilpatrick LA, Bhatt RR, Vora P, Vaughan A, Dong TS & Gupta A. Stress-resilience impacts psychological wellbeing as evidenced by brain-gut microbiome interactions. Nature Mental Health. 2024
• Guan M, Dong TS, Subramanyam V, Guo Y, Bhatt RR, Vaughan A, Barry RL, Gupta A. Improved psychosocial measures associated with physical activity may be explained by alterations in brain-gut microbiome signatures. Nature. 26 June 2023
• Osadchiy V, Bal R, Mayer EA, Kunapuli R, Dong T, Vora P, Petrasek D, Liu C, Stains J, Gupta A. Machine learning model to predict obesity using gut metabolite and brain microstructure. Nature Scientific Reports, 13, article number 5488 (2023)
• Sarnoff RP, Bhatt RR, Osadchiy V, Dong T, Labus JS, Kilpatrick LA, Chen Z, Subramanyam V, Zhang Y, Ellingson BM, Naliboff B, Chang L, Mayer EA, Gupta A. A multi-omic brain gut microbiome signature differs between IBS subjects with different bowel habits. Neuropharmacology. Volume 225, 1 March 2023, 109381
• Dong TS, Guan M, Mayer EA, Stains J, Liu C, Vora P, Jacobs JP, Lagishetty V, Chang L, Barry RL, Gupta A. Obesity is associated with a distinct brain-gut microbiome signature that connects Prevotella and Bacteroides to the brain’s reward center. Gut Microbes, 2022. In press
• Gupta A, Osadchiy V, Mayer EA. Brain-gut microbiome interactions in obesity and food addiction. Nature Reviews: Gastroenterology Hepatology. 2020. doi: 10.1038/s41575-020-0341-5. [E-pub ahead of print. PMCID: In Progress
• Dong TS, Mayer EA, Osadchiy V, Chang C, Katza W, Lagishetty V, Gonzalez K, Kalani A, Stains J, Jacobs JP, Long VD, Gupta A. A distinct brain-gut-microbiome profile exists for females with obesity and food addiction. Obesity. 2020. 28(8): 1477-1486. PMCID: PMC7494955
• Osadchiy V, Labus JS, Gupta A, Jacobs J, Ashe-McNalley C, Hsiao EY, Mayer EA. Correlation of tryptophan metabolites with connectivity of extended central reward network in healthy subjects. Plos One. 2018. 13(8): e0201772. doi: 10.1371/journal.pone.0201772. [Epub ahead of print] PMCID: PMC6078307
• Gupta A, Cole S, Labus JS, Joshi S, Nguyen TJ, Kilpatrick L, Hong JY, Tillisch K, Chang L, Mayer EA. Gene expression profiles in peripheral blood mononuclear cells correlate with salience network activity in chronic visceral pain. Neurogastroenterology and Motility. 2017, 29(6). PMCID: PMC5503466
• Labus JS, Osadchiy V, Hsiao EY, Tap J, Derrien M, Gupta A, Le Nevé B, Grinsvall C, Öhman L, Törnblom H, Simren M, Mayer EA. Evidence for an association of gut microbial clostridia with brain functional connectivity and gastroentestinal sensorimotor function in irritable bowel syndrome: Based on tripartite analysis. Microbiome, 2019. 7(1): 45 doi: 10.1186/s40168-019-0656-z. PMCID: PMC6429755