Grants and Funding
Grants
Yamaha Motor Corporation
Gupta / Naliboff (PIs)
August 2023
Understanding the links between stress and biology is critical as stress can lead to negative mental and physical health outcomes. And developing innovative, easy to implement and effective interventions benefits all who live in stressful environments. The Yamaha YEX Intervention immersive room, developed by Yamaha Motor Corporation, offers individuals tools to destress and refocus. Drs. Gupta and Naliboff will partner with Yamaha Motor Corporation to conduct a study to identify the benefits of using the YEX immersive room to improve mental well-being and to reduce stress. Specifically, they will test for improvements in mental well-being, mood, cognitive function and level of stress, as well as changes in biological markers (specifically in the brain as measured by MRI, metabolites, and inflammatory markers) following regular use of YEX immersion.
UCLA Technology and Development Group Innovation Therapeutics Competition
Gupta / Dong (PIs)
February 2022
Provided funding to conduct a clinical trial on our patented probiotic micture to treat obesity and food addiction.
NIH/NIMHD R01 MD015904
Gupta (PI)
04/01/2021 – 12/30/25
Social Isolation and Discrimination as Stressors Influencing Brain-Gut Microbiome Alterations Among Filipino and Mexican Americans
This proposal aims to examine how the stressors of social isolation and discrimination are related to eating behaviors and dietary patterns, and how these behaviors affect the brain-gut-microbiome axis in Mexican and Filipina women.
NIH/NIDDK K23 DK106528
Gupta (PI)
05/01/2016-04/31/2022
Role of Inflammatory Processes in Reward Network Alterations in Obesity
This proposal seeks to understand the underlying mechanisms of altered ingestive behaviors in obesity as a result of the influence of adverse environmental factors on the bidirectional brain-immune loop.
NIH/NIDDK R03 DK121025
Gupta (PI)
02/01/2020-01/30/2022
Role of the Gut Microbiome in Reward Network Alterations in Obesity
This proposal seeks to understand the sex differences in the influence of the gut microbiome on brain patterns in the extended reward system in obesity.
Danone
Gupta (PI)
12/16/2020-03/01/2022
Pilot Study Aimed to Determine the Optimal Design for the UCLA/Danone Probiotic Intervention Study Related to Stress
The goal of this pilot study is to identify the optimal population and methodology for the planned probiotic intervention study in Phase II of the collaboration.
Biocodex Microbiota Foundation Grant
Gupta (PI)
02/01/2020-01/30/2022
Effect of a Fasting Mimicking Diet on Alterations in the Brain-Gut Microbiome-Immune Axis in Females with Metabolic Syndrome
This proposal seeks to assess the changes in the brain and in the gut microbiome as measured by 16S and metabolites after a fasting mimicking intervention in obese females with metabolic syndrome.
U19 AG063744
Kaddurah-Daouk (PI)
07/01/2019 – 06/30/2024
Duke University/NIH
The Alzheimer's Gut Microbiome Project
Project: A multi-Omics Molecular, Brain, Biomarker Signature for Progressive Cognitive and AD
Although most research has focused on a biological system (e.g., genetics, proteomics, metabolomics blood biomarkers, brain connectomics), the goal of the proposed analyses is to combine several multi-omics data sets obtained in projects 1, 2 and 3, along with our expertise in multimodal neuroimaging, computational and biostatistics, and advanced bioinformatics into a single framework, a biological interaction network.
Role: Subcontract Co-I
U54 DK064539
Mayer/Chang (MPI)
05/01/2020-06/30/2025
Sex Related Differences in Brain Gut Microbiome Interactions in Irritable Bowel Syndrome
This proposal aims to gain a better understanding of the role of the gut microbiome and female sex hormones in the modulation of brain gut microbiome interactions in two of the most common disorders of the gastrointestinal tract, irritable bowel syndrome and chronic functional constipation.
Role: Project Co-Lead
AGA-Rome Foundation
Gupta (PI)
10/01/2019-03/31/2021
Functional GI and Motility Disorders Pilot Research Award
Cognitive Behavioral Therapy Leads to Bidirectional Changes in Brain-Gut Axis for Obesity
This proposal seeks to assess the changes in the brain and in the gut microbiome as measured by 16S and metabolites after a cognitive behavior therapy in an obese sample.
Completed Research Support
NIH/NIDDK DK 041301
Gupta (PI)
12/01/2018 - 11/30/2019
UCLA Clinical and Translational Science Institute (Intramural Award: CURE/CTSI Pilot and Feasibility Study
Sex Differences in Microbiome-Related Alterations in Brain Signatures in Obesity
This proposal seeks to understand the sex differences in the influence of the gut microbiome on brain patterns in the extended reward system in obesity.
NIH/NCATS UL1TR001881
Gupta (PI)
12/01/2019-11/30/2020
UCLA Clinical and Translational Science Institute (Intramural Award: CURE/CTSI Pilot and Feasibility Study)
Sex Differences in Brain-Gut Microbiome-Immune Interactions in Obesity and Food Addiction
This proposal seeks to understand the sex differences in the influence of the brain-gut microbiome-and immune interactions in food addiction and obesity.